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BMC Dermatology
Published in: BMC Dermatology 1/2019

Open Access 01-12-2019 | Lice | Research article

High efficacy of a dimeticone-based pediculicide following a brief application: in vitro assays and randomized controlled investigator-blinded clinical trial

Authors: Jorg Heukelbach, Doerte Wolf, John Marshall Clark, Hans Dautel, Kristina Roeschmann

Published in: BMC Dermatology | Issue 1/2019

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Abstract

Background

Increasing resistance of head lice against neurotoxic agents and safety concerns have led to the search for treatment alternatives. Dimeticones with a physical mode of action are safe, and bear a reduced risk for the development of resistance.

Methods

We performed in vitro bioassays to assess pediculicidal and ovicidal activities of a new dimeticone-based product, and a randomized controlled clinical trial to assess efficacy, following 10 min application. Of 153 individuals screened, 100 participants with active head louse infestations were randomly assigned to treatment with either a dimeticone-based test product, or a 0.5% permethrin-based reference product (50 participants per group). Participants received two topical applications of either the test (10 min) or reference products (45 min) at days 0 and 7 or 8. Outcome measures included the efficacies of treatment and their safety, as well as global and local tolerability at baseline, and days 1, 7, and 10.

Results

After 10 min exposure, all lice treated with the dimeticone test product were classified as non-viable in the in vitro assay. Ovicidal activity after treatment of eggs with the dimeticone test product was 96.8%. In the clinical trial, 96 patients completed all study visits. In the full analysis set (FAS) population, on day 1 after one application, 98% of patients were cured in the test group, as compared to 84% cured in the reference group. All participants in both groups were free of head lice on day 10, following two applications (100% cure rate). In total, 42 adverse events (AEs) in 23 patients of both treatment groups were recorded, with the majority of AEs classified as mild.

Conclusions

We have shown a high level of pediculicidal and ovicidal activity, and clinical efficacy and safety, of a brief application of a new dimeticone-based product. The short application time and reduced risk for the development of resistance are key drivers for improved patients’ compliance.

Trial registration

EU Clinical Trials Register EudraCT 2016–004635-20. Registered 14 November 2016.
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Metadata
Title
High efficacy of a dimeticone-based pediculicide following a brief application: in vitro assays and randomized controlled investigator-blinded clinical trial
Authors
Jorg Heukelbach
Doerte Wolf
John Marshall Clark
Hans Dautel
Kristina Roeschmann
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Dermatology / Issue 1/2019
Electronic ISSN: 1471-5945
DOI
https://doi.org/10.1186/s12895-019-0094-4

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