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BMC Urology
Published in: BMC Urology 1/2018

Open Access 01-12-2018 | Research article

Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

Authors: Sarwat Jahan, Asma Munawar, Suhail Razak, Sara Anam, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Mahmoud Abulmeaty, Ali Almajwal

Published in: BMC Urology | Issue 1/2018

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Abstract

Background

Cisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats.

Methods

28 male rats were divided into four groups. First group was given saline orally while second group received intra-peritoneal (i.p) injection of cisplatin (7 mg/kg) on day first and received saline for next 13 days. Third group received i.p injection of cisplatin at day one and treated with rutin (75 mg/kg) orally for next 13 days. Fourth group was treated with rutin orally for 13 days. Animals were sacrificed on 14th day and reproductive organs were analyzed for various parameters.

Results

Cisplatin treatment resulted in a significant decrease in daily sperm production, decrease in head length and % DNA in head, reduction of epithelial cell height, tubular diameter, reduction of the number of spermatogonia, spermatocytes and spermatids, increase in the thiobarbituric acid reactive substances (TBARS) and oxidative stress in testicular tissues, and change of the intra-testicular testosterone concentrations. Rutin co-treatment resulted in reversing cisplatin effect on DNA damage, sperm count, histological and biochemical parameters.

Conclusion

These results indicated that rutin co-treatment could ameliorate cisplatin-induced reproductive toxicity in male rats.
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Metadata
Title
Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats
Authors
Sarwat Jahan
Asma Munawar
Suhail Razak
Sara Anam
Qurat Ul Ain
Hizb Ullah
Tayyaba Afsar
Mahmoud Abulmeaty
Ali Almajwal
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2018
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-018-0421-9

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