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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2019

Open Access 01-12-2019 | Osteonecrosis | Research article

Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head

Authors: Jiang Jiang, Xuqiang Liu, Baojian Lai, Dengjiong Hu, Lizhen Lai, Jiaxiang Xu, Songqing Chen, Xiaofeng Li

Published in: BMC Musculoskeletal Disorders | Issue 1/2019

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Abstract

Background

The correlation between peripheral blood neutrophil level and osteonecrosis of the femoral head (ONFH) has not been extensively studied. Thus, we aimed to investigate the correlation between neutrophil level in the peripheral blood (neutrophil granulocyte) and ONFH.

Methods

A total of 984 cases of ONFH and femoral neck fractures (non-ONFH) diagnosed at the Department of Orthopedics at our institution between January 1, 2011 and December 31, 2016 were retrospectively reviewed. The ONFH and non-ONFH groups comprised 488 and 496 cases, respectively. Basic information and peripheral blood cell levels of the two groups were compared.

Results

The patients’ mean age was 59.89 ± 17.06 years (range: 38–82 years). There were 457 male and 527 female patients, with a male-to-female ratio of 1:1.15. We found that neutrophil granulocyte levels and percentage of neutrophil granulocytes were significantly different between the ONFH and non-ONFH groups. Multimodal regression analysis showed that the percentage of neutrophil granulocytes was an independent protective factor against ONFH.

Conclusions

The factors influencing ONFH are neutrophil granulocyte levels and percentage of neutrophil granulocytes. Percentage of neutrophil granulocytes has a significant correlation with aseptic femoral head necrosis, providing a new perspective and direction for further study of femoral head necrosis.
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Metadata
Title
Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head
Authors
Jiang Jiang
Xuqiang Liu
Baojian Lai
Dengjiong Hu
Lizhen Lai
Jiaxiang Xu
Songqing Chen
Xiaofeng Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2019
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-019-2778-7

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