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Open Access 01-12-2017 | Research article

Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders

Authors: Judith E. Gold, David M. Hallman, Fredrik Hellström, Martin Björklund, Albert G. Crenshaw, Svend Erik Mathiassen, Mary F. Barbe, Sayed Ali

Published in: BMC Musculoskeletal Disorders | Issue 1/2017

Abstract

Background

This study systematically summarizes quantitative imaging biomarker research in non-traumatic neck and shoulder musculoskeletal disorders (MSDs). There were two research questions: 1) Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?, 2) Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Methods

PubMed and SCOPUS were used for the literature search. One hundred and twenty-five studies met primary inclusion criteria. Data were extracted from 49 sufficient quality studies.

Results

Most of the 125 studies were cross-sectional and utilized convenience samples of patients as both cases and controls. Only half controlled for potential confounders via exclusion or in the analysis. Approximately one-third reported response rates. In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied. The literature synthesis suggested that neck muscle size may be decreased in neck pain, and trapezius myalgia and neck/shoulder pain may be associated with reduced vascularity in the trapezius and reduced trapezius oxygen saturation at rest and in response to upper extremity tasks. Reduced vascularity in the supraspinatus tendon may also be a feature in rotator cuff tears. Five of eight studies showed an association between a quantitative imaging marker and MSD severity.

Conclusions

Although research on quantitative imaging biomarkers is still in a nascent stage, some MSD biomarkers were identified. There are limitations in the articles examined, including possible selection bias and inattention to potentially confounding factors. Recommendations for future studies are provided.

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Title: Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders
Authors: Judith E. Gold
David M. Hallman
Fredrik Hellström
Martin Björklund
Albert G. Crenshaw
Svend Erik Mathiassen
Mary F. Barbe
Sayed Ali
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Musculoskeletal Disorders / Issue 1/2017
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-017-1694-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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