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BMC Pulmonary Medicine
Published in: BMC Pulmonary Medicine 1/2020

01-12-2020 | Bronchial Asthma | Research article

Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

Authors: Bas C. P. van Dijk, Henrik Svedsater, Andreas Heddini, Linda Nelsen, Janita S. Balradj, Cathelijne Alleman

Published in: BMC Pulmonary Medicine | Issue 1/2020

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Abstract

Background

The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not fully understood. Here, we evaluate how ACT scores relate to other clinical, patient-reported, or economic asthma outcomes.

Methods

A targeted literature search of online databases and conference abstracts was performed. Data were extracted from articles reporting ACT score alongside one or more of: Asthma Control Questionnaire (ACQ) score; rescue medication use; exacerbations; lung function; health−/asthma-related quality of life (QoL); sleep quality; work and productivity; and healthcare resource use (HRU) and costs.

Results

A total of 1653 publications were identified, 74 of which were included in the final analysis. Of these, 69 studies found that improvement in ACT score was related to improvement in outcome(s), either as correlation or by association. The level of evidence for each relationship differed widely between outcomes: substantial evidence was identified for relationships between ACT score and ACQ score, lung function, and asthma-related QoL; moderate evidence was obtained for relationships between ACT score and rescue medication use, exacerbations, sleep quality, and work and productivity; limited evidence was identified for relationships between ACT score and general health-related QoL, HRU, and healthcare costs.

Conclusions

Findings of this review suggest that the ACT is an appropriate measure for overall asthma impact and support its use in clinical trial settings.
GlaxoSmithKline plc. study number HO-17-18170.
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Metadata
Title
Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review
Authors
Bas C. P. van Dijk
Henrik Svedsater
Andreas Heddini
Linda Nelsen
Janita S. Balradj
Cathelijne Alleman
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2020
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-020-1090-5

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