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BMC Pulmonary Medicine

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Open Access 01-12-2017 | Research article

Three-dimensional substructure measurements for the differential diagnosis of ground glass nodules

Authors: Mingzheng Peng, Gang Yu, Chengzhong Zhang, Cuidi Li, Jinwu Wang

Published in: BMC Pulmonary Medicine | Issue 1/2017

Abstract

Background

We analyzed the differences between maximum and peak computed tomography (CT) numbers (M-P), respectively representing the densities of the solid center and the main periphery of ground-glass nodules (GGNs), and the average change in M-P velocity (V(M-P)) during follow-up to differentiate between pre-invasive (PIA) and invasive adenocarcinoma (IAC).

Methods

Data of 102 patients were retrospectively collected and analyzed in our study including 43 PIAs and 59 IACs. Diameters, total volumes, and the maximum and peak CT numbers in CT number histograms were measured and followed for at least 3 months. This study was registered retrospectively.

Results

The M-P values for IACs were higher than those for PIAs (p = 0.001), with an area under the curve (AUC) of 0.810 and a threshold of 489.5 Hounsfield units (HU) in ROC analysis. The V(M-P) values for IACs were smaller than those for PIAs (p = 0.04), with an AUC of 0.805 and a threshold of 11.01 HU/day.

Conclusions

M-P and V(M-P) values may help distinguish IACs from PIAs by representing the changes in the sub-structural densities of GGNs during follow-up.

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Title: Three-dimensional substructure measurements for the differential diagnosis of ground glass nodules
Authors: Mingzheng Peng
Gang Yu
Chengzhong Zhang
Cuidi Li
Jinwu Wang
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Pulmonary Medicine / Issue 1/2017
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-017-0438-y

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Three-dimensional substructure measurements for the differential diagnosis of ground glass nodules

Abstract

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Results

Conclusions

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Abstract

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