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Open Access 01-12-2021 | Mood Disorders | Research article

The effect of depressive symptomatology on the association of vitamin D and sleep

Authors: Roland Mergl, Ezgi Dogan-Sander, Anja Willenberg, Kerstin Wirkner, Jürgen Kratzsch, Steffi Riedel-Heller, Antje-Kathrin Allgaier, Ulrich Hegerl, Christian Sander

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

Sleep disorders and vitamin D deficiency are highly prevalent health problems. Few studies examined the effect of vitamin D concentrations on objectively measured sleep with high methodological quality and temporal proximity. Previous analysis within the LIFE-Adult-Study suggested that a lower concentration of serum vitamin D was associated with both shorter and later night sleep. However, no conclusion about underlying mechanisms could be drawn. We addressed the question whether this relationship is explained by the presence of depressive syndromes, which are linked to both vitamin D deficiency and sleep disturbances.

Methods

It was investigated whether the association of vitamin D concentrations and night sleep parameters is mediated or moderated by depressive symptomatology. We investigated a subset (n = 1252) of the community sample from the LIFE-Adult-Study, in which sleep parameters had been objectively assessed using actigraphy, based on which two sleep parameters were calculated: night sleep duration and midsleep time. Serum 25(OH) D concentrations were measured using an electrochemiluminescence immunoassay. Depressive symptomatology was evaluated with the Centre for Epidemiological Studies Depression Scale. The mediation effect was analyzed by using Hayes’ PROCESS macro tool for SPSS for Windows.

Results

The depressive symptomatology was neither significantly associated with night sleep duration nor midsleep time. The associations between vitamin D concentrations and night sleep duration/midsleep time through mediation by depressive symptomatology were not significant. Corresponding moderator analyses were also non-significant.

Conclusion

The associations between vitamin D concentrations and night sleep parameters (sleep duration and midsleep time) seem to be neither mediated nor moderated by depressive symptomatology.

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Title: The effect of depressive symptomatology on the association of vitamin D and sleep
Authors: Roland Mergl
Ezgi Dogan-Sander
Anja Willenberg
Kerstin Wirkner
Jürgen Kratzsch
Steffi Riedel-Heller
Antje-Kathrin Allgaier
Ulrich Hegerl
Christian Sander
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Mood Disorders
Vitamin D Deficiency
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03176-4

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The effect of depressive symptomatology on the association of vitamin D and sleep

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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