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Open Access 01-12-2015 | Study protocol

The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

Authors: Markus Loeffler, Christoph Engel, Peter Ahnert, Dorothee Alfermann, Katrin Arelin, Ronny Baber, Frank Beutner, Hans Binder, Elmar Brähler, Ralph Burkhardt, Uta Ceglarek, Cornelia Enzenbach, Michael Fuchs, Heide Glaesmer, Friederike Girlich, Andreas Hagendorff, Madlen Häntzsch, Ulrich Hegerl, Sylvia Henger, Tilman Hensch, Andreas Hinz, Volker Holzendorf, Daniela Husser, Anette Kersting, Alexander Kiel, Toralf Kirsten, Jürgen Kratzsch, Knut Krohn, Tobias Luck, Susanne Melzer, Jeffrey Netto, Matthias Nüchter, Matthias Raschpichler, Franziska G. Rauscher, Steffi G. Riedel-Heller, Christian Sander, Markus Scholz, Peter Schönknecht, Matthias L. Schroeter, Jan-Christoph Simon, Ronald Speer, Julia Stäker, Robert Stein, Yve Stöbel-Richter, Michael Stumvoll, Attila Tarnok, Andrej Teren, Daniel Teupser, Francisca S. Then, Anke Tönjes, Regina Treudler, Arno Villringer, Alexander Weissgerber, Peter Wiedemann, Silke Zachariae, Kerstin Wirkner, Joachim Thiery

Published in: BMC Public Health | Issue 1/2015

Abstract

Background

The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part of Germany. The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE). Our objective is to investigate prevalences, early onset markers, genetic predispositions, and the role of lifestyle factors of major civilization diseases, with primary focus on metabolic and vascular diseases, heart function, cognitive impairment, brain function, depression, sleep disorders and vigilance dysregulation, retinal and optic nerve degeneration, and allergies.

Methods/design

The study covers a main age range from 40-79 years with particular deep phenotyping in elderly participants above the age of 60. The baseline examination was conducted from August 2011 to November 2014. All participants underwent an extensive core assessment programme (5-6 h) including structured interviews, questionnaires, physical examinations, and biospecimen collection. Participants over 60 underwent two additional assessment programmes (3-4 h each) on two separate visits including deeper cognitive testing, brain magnetic resonance imaging, diagnostic interviews for depression, and electroencephalography.

Discussion

The participation rate was 33 %. The assessment programme was accepted well and completely passed by almost all participants. Biomarker analyses have already been performed in all participants. Genotype, transcriptome and metabolome analyses have been conducted in subgroups. The first follow-up examination will commence in 2016.

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Title: The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany
Authors: Markus Loeffler
Christoph Engel
Peter Ahnert
Dorothee Alfermann
Katrin Arelin
Ronny Baber
Frank Beutner
Hans Binder
Elmar Brähler
Ralph Burkhardt
Uta Ceglarek
Cornelia Enzenbach
Michael Fuchs
Heide Glaesmer
Friederike Girlich
Andreas Hagendorff
Madlen Häntzsch
Ulrich Hegerl
Sylvia Henger
Tilman Hensch
Andreas Hinz
Volker Holzendorf
Daniela Husser
Anette Kersting
Alexander Kiel
Toralf Kirsten
Jürgen Kratzsch
Knut Krohn
Tobias Luck
Susanne Melzer
Jeffrey Netto
Matthias Nüchter
Matthias Raschpichler
Franziska G. Rauscher
Steffi G. Riedel-Heller
Christian Sander
Markus Scholz
Peter Schönknecht
Matthias L. Schroeter
Jan-Christoph Simon
Ronald Speer
Julia Stäker
Robert Stein
Yve Stöbel-Richter
Michael Stumvoll
Attila Tarnok
Andrej Teren
Daniel Teupser
Francisca S. Then
Anke Tönjes
Regina Treudler
Arno Villringer
Alexander Weissgerber
Peter Wiedemann
Silke Zachariae
Kerstin Wirkner
Joachim Thiery
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-015-1983-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

Abstract

Background

Methods/design

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods/design

Discussion

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