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BMC Psychiatry
Published in: BMC Psychiatry 1/2019

Open Access 01-12-2019 | Schizophrenia | Research article

Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population

Authors: Ziqi Wang, Tian Zhang, Jing Liu, Han Wang, Tianlan Lu, Meixiang Jia, Dai Zhang, Lifang Wang, Jun Li

Published in: BMC Psychiatry | Issue 1/2019

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Abstract

Background

Autism is a complex neurodevelopmental disorder with high heritability. Zinc finger protein 804A (ZNF804A) was suggested to play important roles in neurodevelopment. Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A was strongly associated with schizophrenia and might influence social interaction. Only one study explored the significance of ZNF804A polymorphisms in autism, which discovered that rs7603001 was nominally associated with autism. Moreover, no previous study investigated the association between ZNF804A and autism in a Han Chinese population. Here, we investigated whether these two SNPs (rs1344706 and rs7603001) in ZNF804A contribute to the risk of autism in a Han Chinese population.

Methods

We performed a family-based association study in 640 Han Chinese autism trios. Sanger sequencing was used for sample genotyping. Then, single marker association analyses were conducted using the family-based association test (FBAT) program.

Results

No significant association was found between the two SNPs (rs1344706 and rs7603001) in ZNF804A and autism (P > 0.05).

Conclusions

Our findings suggested that rs1344706 and rs7603001 in ZNF804A might not be associated with autism in a Han Chinese population.
Appendix
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Metadata
Title
Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population
Authors
Ziqi Wang
Tian Zhang
Jing Liu
Han Wang
Tianlan Lu
Meixiang Jia
Dai Zhang
Lifang Wang
Jun Li
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Schizophrenia
Published in
BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-019-2144-1

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