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Published in: BMC Psychiatry 1/2019

Open Access 01-12-2019 | Tuberculosis | Research article

Prevalence and associated factors of depression among tuberculosis patients in Eastern Ethiopia

Authors: Tamirat Tesfaye Dasa, Aklilu Abrham Roba, Fitsum Weldegebreal, Frehiwot Mesfin, Abiyot Asfaw, Habtamu Mitiku, Zelalem Teklemariam, Bahubali Jinnappa Geddugol, Mahantash Naganuri, Hilina Befikadu, Eden Tesfaye

Published in: BMC Psychiatry | Issue 1/2019

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Abstract

Background

Depression among tuberculosis patients, especially in settings with low economic status is common. Screening for depression in all levels of health facilities can identify patients who need support and treatment for depression.

Objective

The aim of this study was to assess the prevalence and associated factors of depression among tuberculosis patients in Eastern Ethiopia.

Methods

An institutional based cross-sectional study was conducted among 403 tuberculosis patients attending in eleven tuberculosis treatment centers in eastern Ethiopia from February to July 2017. Depression was measured using the Patient Health Questionnaire. Data was collected consecutively until the required sample size was obtained. Tuberclusis  patients who were under anti tuberculosis treatments for more than one month were included. Data were analyzed with Statistical Package for Social Sciences (SPSS) version 20. Bivariate and multivariate logistic regression models were applied to identify independent factors for dependent variable depression and P-values < 0.05 considered statistically significant.

Results

A total of 403 tuberculosis patients were included in the study. The prevalence of depression among tuberculosis patients was 51.9% (95%CI = 42.7, 62.2%) with 34.2% were mild cases. In our logistic regression analysis, odds of developing depression among tuberculosis patients with age less than 25 years were 0.5(50% protective effect) [AOR = 0.5, 95% CI 0.26–0.99] where as patients with a monthly income within the 25thpercentile were four times higher odds to have depression [AOR = 3.98, 95% CI: 2.15–7.39].

Conclusion

The prevalence of depression was high in this study. Age, low monthly income, the category of patients as “new tuberculosis treatment” and the first 3 months of treatment was associated with depression among tuberculosis patients. Health facilities should integrating mental health services with tuberculosis clinics, especially assessing and treating TB patients for depression, is vital.
Literature
1.
go back to reference WHO. Depression and other common mental disorders. In: Global Health estimates Geneva; 2017. WHO. Depression and other common mental disorders. In: Global Health estimates Geneva; 2017.
2.
go back to reference Hunduma G, Girma M, Digaffe T, Weldegebreal F, Tola A. Prevalence and determinants of common mental illness among adult residents of Harari regional state Eastern Ethiopia. The Pan African medical journal. 2017;28:262.CrossRef Hunduma G, Girma M, Digaffe T, Weldegebreal F, Tola A. Prevalence and determinants of common mental illness among adult residents of Harari regional state Eastern Ethiopia. The Pan African medical journal. 2017;28:262.CrossRef
3.
go back to reference Doherty AM, Kelly J, McDonald C, O’Dywer AM, Keane J, Cooney J. A review of the interplay between tuberculosis and mental health. Gen Hosp Psychiatry. 2013 Jul-Aug;35(4):398–406.CrossRef Doherty AM, Kelly J, McDonald C, O’Dywer AM, Keane J, Cooney J. A review of the interplay between tuberculosis and mental health. Gen Hosp Psychiatry. 2013 Jul-Aug;35(4):398–406.CrossRef
4.
go back to reference Ambaw F, Mayston R, Hanlon C, Alem A. Burden and presentation of depression among newly diagnosed individuals with TB in primary care settings in Ethiopia. BMC psychiatry. 2017;17(1):57.CrossRef Ambaw F, Mayston R, Hanlon C, Alem A. Burden and presentation of depression among newly diagnosed individuals with TB in primary care settings in Ethiopia. BMC psychiatry. 2017;17(1):57.CrossRef
5.
go back to reference Ige OM, Lasebikan VO. Prevalence of depression in tuberculosis patients in comparison with non-tuberculosis family contacts visiting the DOTS clinic in a Nigerian tertiary care hospital and its correlation with disease pattern. Ment Health Fam Med. 2011;8(4):235–41.PubMedPubMedCentral Ige OM, Lasebikan VO. Prevalence of depression in tuberculosis patients in comparison with non-tuberculosis family contacts visiting the DOTS clinic in a Nigerian tertiary care hospital and its correlation with disease pattern. Ment Health Fam Med. 2011;8(4):235–41.PubMedPubMedCentral
6.
go back to reference Kehbila J, Ekabe CJ, Aminde LN, Noubiap JJN, Fon PN, Monekosso GL. Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the southwest region of Cameroon. Infect Dis Poverty. 2016;5(51). Kehbila J, Ekabe CJ, Aminde LN, Noubiap JJN, Fon PN, Monekosso GL. Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the southwest region of Cameroon. Infect Dis Poverty. 2016;5(51).
7.
go back to reference Amreen and Rizvi N. Frequency of depression and anxiety among tuberculosis patients. Journal of Tuberculosis Research. 2016;4:183–90.CrossRef Amreen and Rizvi N. Frequency of depression and anxiety among tuberculosis patients. Journal of Tuberculosis Research. 2016;4:183–90.CrossRef
8.
go back to reference Walker IF, Khan AM, Khan AM, Khan NM, Ayub RM, Ghias KN, Walley JD. Depression among multidrug-resistant tuberculosis patients in Punjab, Pakistan: a large cross-sectional study. International Journal of Tuberculosis and Lung Disease. 2018;22(7):773–8.CrossRef Walker IF, Khan AM, Khan AM, Khan NM, Ayub RM, Ghias KN, Walley JD. Depression among multidrug-resistant tuberculosis patients in Punjab, Pakistan: a large cross-sectional study. International Journal of Tuberculosis and Lung Disease. 2018;22(7):773–8.CrossRef
9.
go back to reference Ugarte-Gil C, Ruiz P, Zamudio C, Canaza L, Otero L, Kruger H, Seas C. Association of major depressive episode with negative outcomes of tuberculosis treatment. PLoS One. 2013;8(7):e69514.CrossRef Ugarte-Gil C, Ruiz P, Zamudio C, Canaza L, Otero L, Kruger H, Seas C. Association of major depressive episode with negative outcomes of tuberculosis treatment. PLoS One. 2013;8(7):e69514.CrossRef
10.
go back to reference Koyanagi A, Vancampfort D, Carvalho AF, DeVylder JE, Haro JM, Pizzol D, Veronese N, Stubbs B. Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries. BMC Med. 2017;15(1):209.CrossRef Koyanagi A, Vancampfort D, Carvalho AF, DeVylder JE, Haro JM, Pizzol D, Veronese N, Stubbs B. Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries. BMC Med. 2017;15(1):209.CrossRef
11.
go back to reference Ambaw F, Mayston R, Hanlon C, Medhin G, Alem A. Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia. Bull World Health Organ. 2018;96(4):243–55.CrossRef Ambaw F, Mayston R, Hanlon C, Medhin G, Alem A. Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia. Bull World Health Organ. 2018;96(4):243–55.CrossRef
12.
go back to reference Morris DM, Quezada L, Bhat P, Moser K, Smith J, Perez H. Social,Economic,and psychological impacts of MDR-TBTreatment in Tijuana, Mexico:APatient'sPerspective. Int J Tuberc Lung Dis. 2013;17(7):954–60.CrossRef Morris DM, Quezada L, Bhat P, Moser K, Smith J, Perez H. Social,Economic,and psychological impacts of MDR-TBTreatment in Tijuana, Mexico:APatient'sPerspective. Int J Tuberc Lung Dis. 2013;17(7):954–60.CrossRef
13.
go back to reference Duko B, Gebeyehu A, Ayano G. Prevalence and correlates of depression and anxiety among patients with tuberculosis at WolaitaSodo University hospital and Sodo health center, WolaitaSodo, South Ethiopia, cross sectional study. BMC Psychiatry. 2015;15. Duko B, Gebeyehu A, Ayano G. Prevalence and correlates of depression and anxiety among patients with tuberculosis at WolaitaSodo University hospital and Sodo health center, WolaitaSodo, South Ethiopia, cross sectional study. BMC Psychiatry. 2015;15.
14.
go back to reference Naidoo P, Mwaba K. Helplessness, depression, and social support among people being treated for tuberculosis in South Africa. Soc Behav Pers. 2010;38(10):1323–34.CrossRef Naidoo P, Mwaba K. Helplessness, depression, and social support among people being treated for tuberculosis in South Africa. Soc Behav Pers. 2010;38(10):1323–34.CrossRef
15.
go back to reference Lee L-Y, Tung H-H, Chen S-C, Fu C-H. Perceived stigma and depression in initially diagnosed pulmonary tuberculosis patients. J Clin Nurs. 2017;26(23–24):4813–21.CrossRef Lee L-Y, Tung H-H, Chen S-C, Fu C-H. Perceived stigma and depression in initially diagnosed pulmonary tuberculosis patients. J Clin Nurs. 2017;26(23–24):4813–21.CrossRef
16.
go back to reference Thomas BE, Shanmugam P, Malaisamy M, Ovung S, Suresh C, Subbaraman R, Adinarayanan S, Nagarajan K. Psycho-socio-economic issues challenging multidrug resistant tuberculosis patients: a systematic review. PLoS One. 2016;11:e0147397.CrossRef Thomas BE, Shanmugam P, Malaisamy M, Ovung S, Suresh C, Subbaraman R, Adinarayanan S, Nagarajan K. Psycho-socio-economic issues challenging multidrug resistant tuberculosis patients: a systematic review. PLoS One. 2016;11:e0147397.CrossRef
17.
go back to reference Ambaw F, Mayston R, Hanlon C, Alem A. Burden and presentation of depression among newly diagnosed individuals with TB in primary care settings in Ethiopia. BMC Psychiatry. 2017;17(1). Ambaw F, Mayston R, Hanlon C, Alem A. Burden and presentation of depression among newly diagnosed individuals with TB in primary care settings in Ethiopia. BMC Psychiatry. 2017;17(1).
18.
go back to reference Nugussie DA, Mohammed GA, Tefera AT. Prevalence of smear-positive tuberculosis among patients who visited Saint Paul’s specialized Hospital in Addis Ababa, Ethiopia. Biomed Res Int. 2017;5. Nugussie DA, Mohammed GA, Tefera AT. Prevalence of smear-positive tuberculosis among patients who visited Saint Paul’s specialized Hospital in Addis Ababa, Ethiopia. Biomed Res Int. 2017;5.
19.
go back to reference Hanlon C, Medhin G, Selamu M, Breuer E, Worku B, Hailemariam M, Lund C, Prince M, Fekadu A. Validity of brief sceening questionnaires to detect depression in primary care in Ethiopia. J Affect Disord. 2015;186:32–9.CrossRef Hanlon C, Medhin G, Selamu M, Breuer E, Worku B, Hailemariam M, Lund C, Prince M, Fekadu A. Validity of brief sceening questionnaires to detect depression in primary care in Ethiopia. J Affect Disord. 2015;186:32–9.CrossRef
20.
go back to reference Woledesenbet MA, Shumet Mekonen S, Sori LM, Abegaz TM. Epidemiology of depression and associated factors among asthma patients in Addis Ababa, Ethiopia. Hindawi Psychiatry Journal. 2017;2018, Article ID 5934872:7. Woledesenbet MA, Shumet Mekonen S, Sori LM, Abegaz TM. Epidemiology of depression and associated factors among asthma patients in Addis Ababa, Ethiopia. Hindawi Psychiatry Journal. 2017;2018, Article ID 5934872:7.
21.
go back to reference Tilahun H, Awoke N, Geda B, Mesfin F. Depression and associated factors among adult inpatients at public hospitals of Harari regional state, eastern Ethiopia. Hindawi Psychiatry Journal. 2017;2018, Article ID 6743520:6. Tilahun H, Awoke N, Geda B, Mesfin F. Depression and associated factors among adult inpatients at public hospitals of Harari regional state, eastern Ethiopia. Hindawi Psychiatry Journal. 2017;2018, Article ID 6743520:6.
22.
go back to reference Kroenke K, Spitzer RL, Williams JBW. The PHQ-9. Validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.CrossRef Kroenke K, Spitzer RL, Williams JBW. The PHQ-9. Validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.CrossRef
23.
go back to reference Duko B, Gebeyehu A, Ayano G. Prevalence and correlates of depression and anxiety among patients with tuberculosis at WolaitaSodo University hospital and Sodo health center, WolaitaSodo, South Ethiopia Cross sectional study. BMC Psychiatry. 2015;15(1):214.CrossRef Duko B, Gebeyehu A, Ayano G. Prevalence and correlates of depression and anxiety among patients with tuberculosis at WolaitaSodo University hospital and Sodo health center, WolaitaSodo, South Ethiopia Cross sectional study. BMC Psychiatry. 2015;15(1):214.CrossRef
24.
go back to reference Ambaw F, Mayston R, Hanlon C, Alem A. Burden and presentation of depression among newly diagnosed individuals with TB in primary care settings in Ethiopia. BMC Psychiatry. 2017;17. Ambaw F, Mayston R, Hanlon C, Alem A. Burden and presentation of depression among newly diagnosed individuals with TB in primary care settings in Ethiopia. BMC Psychiatry. 2017;17.
25.
go back to reference Paulo BX, Peixoto B. Emotional distress patients with several types of tuberculosis. A pilot study with patients from the sanatorium Hospital of Huambo. International Journal of Mycobacteriology. 2016;5((Paulo B.X.) Sanatorium Hospital of Huambo, Huambo, Angola):S58.CrossRef Paulo BX, Peixoto B. Emotional distress patients with several types of tuberculosis. A pilot study with patients from the sanatorium Hospital of Huambo. International Journal of Mycobacteriology. 2016;5((Paulo B.X.) Sanatorium Hospital of Huambo, Huambo, Angola):S58.CrossRef
26.
go back to reference Kehbila J, Ekabe CJ, Aminde LN, Noubiap JJ, Fon PN, Monekosso GL. Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the southwest region of Cameroon. Infect Dis Poverty. 2015;5(1):016–0145. Kehbila J, Ekabe CJ, Aminde LN, Noubiap JJ, Fon PN, Monekosso GL. Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the southwest region of Cameroon. Infect Dis Poverty. 2015;5(1):016–0145.
27.
go back to reference Kumar K, Kumar A, Chandra P, Kansal HM. A study of prevalence of depression and anxiety in patients suffering from tuberculosis. Journal of family medicine and primary care. 2016;5(1):150–3.CrossRef Kumar K, Kumar A, Chandra P, Kansal HM. A study of prevalence of depression and anxiety in patients suffering from tuberculosis. Journal of family medicine and primary care. 2016;5(1):150–3.CrossRef
28.
go back to reference Aydin IO, Ulusahin A. Depression, anxiety comorbidity, and disability in tuberculosis and chronic obstructive pulmonary disease patients: applicability of GHQ-12. Gen Hosp Psychiatry. 2001;23:77–83.CrossRef Aydin IO, Ulusahin A. Depression, anxiety comorbidity, and disability in tuberculosis and chronic obstructive pulmonary disease patients: applicability of GHQ-12. Gen Hosp Psychiatry. 2001;23:77–83.CrossRef
29.
go back to reference Mukherjee JS, Rich ML, Socci AR, Joseph JK, Viru FA, Shin SS, Furin JJ, Becerra MC, Barry DJ, Kim JY, et al. Programmes and principles in treatment of multidrug-resistant tuberculosis. Lancet. 2004;363(9407):474–81.CrossRef Mukherjee JS, Rich ML, Socci AR, Joseph JK, Viru FA, Shin SS, Furin JJ, Becerra MC, Barry DJ, Kim JY, et al. Programmes and principles in treatment of multidrug-resistant tuberculosis. Lancet. 2004;363(9407):474–81.CrossRef
30.
go back to reference Thomas BE, Shanmugam P, Malaisamy M, Ovung S, Suresh C, Subbaraman R, Adinarayanan S, Nagarajan K. Psycho-socio-economic issues challenging multidrug resistant tuberculosis patients: a systematic review. PLoS One. 2016;11(1):e0147397.CrossRef Thomas BE, Shanmugam P, Malaisamy M, Ovung S, Suresh C, Subbaraman R, Adinarayanan S, Nagarajan K. Psycho-socio-economic issues challenging multidrug resistant tuberculosis patients: a systematic review. PLoS One. 2016;11(1):e0147397.CrossRef
31.
go back to reference Nega Assefa, Aklilu Abrham Roba, Tekabe Abdosh Ahmed, Jelalu Kemal Birmeka, Zergaw ED: Prevalence and factors associated with trachoma among primary school children in Harari region, eastern Ethiopia Ophthalmology Research: An International Journal 2017, 7(3). Nega Assefa, Aklilu Abrham Roba, Tekabe Abdosh Ahmed, Jelalu Kemal Birmeka, Zergaw ED: Prevalence and factors associated with trachoma among primary school children in Harari region, eastern Ethiopia Ophthalmology Research: An International Journal 2017, 7(3).
32.
go back to reference Chen X, Zhao Y, Xu Y, Zhang H, Sun S, Gao Z, He X. Analyzing the status of depression and anxiety of new registered tuberculosis outpatients and correlations with social support influence factors. National Medical Journal of China. 2016;96(34):2749–53.PubMed Chen X, Zhao Y, Xu Y, Zhang H, Sun S, Gao Z, He X. Analyzing the status of depression and anxiety of new registered tuberculosis outpatients and correlations with social support influence factors. National Medical Journal of China. 2016;96(34):2749–53.PubMed
33.
go back to reference Peltzer K, Naidoo P, Matseke G, Louw J, McHunu G, Tutshana B. Prevalence of psychological distress and associated factors in tuberculosis patients in public primary care clinics in South Africa. BMC Psychiatry. 2012;12(1). Peltzer K, Naidoo P, Matseke G, Louw J, McHunu G, Tutshana B. Prevalence of psychological distress and associated factors in tuberculosis patients in public primary care clinics in South Africa. BMC Psychiatry. 2012;12(1).
34.
go back to reference Karlin DM, Evans C, Loiselle C, Zevallos K, Fernandez F, Allen N, Montoya R, Boccia D. Depression is common in TB patients and is associated with treatment abandonment. J Investig Med. 2012;60(1):167. Karlin DM, Evans C, Loiselle C, Zevallos K, Fernandez F, Allen N, Montoya R, Boccia D. Depression is common in TB patients and is associated with treatment abandonment. J Investig Med. 2012;60(1):167.
35.
go back to reference Pachi A, Bratis D, Moussas G, Tselebis A. Psychiatric morbidity and other factors affecting treatment adherence in pulmonary tuberculosis patients. Tuberc Res Treat. 2013;2012:489865. Pachi A, Bratis D, Moussas G, Tselebis A. Psychiatric morbidity and other factors affecting treatment adherence in pulmonary tuberculosis patients. Tuberc Res Treat. 2013;2012:489865.
36.
go back to reference Kehbila J, Ekabe CJ, Aminde LN, Noubiap JJN, Fon PN, Monekosso GL. Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the southwest region of Cameroon. Infectious Diseases of Poverty. 2016;5. Kehbila J, Ekabe CJ, Aminde LN, Noubiap JJN, Fon PN, Monekosso GL. Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the southwest region of Cameroon. Infectious Diseases of Poverty. 2016;5.
37.
go back to reference Roba AA, Dasa TT, Weldegebrea F, Asfaw A, Mitiku H, Teklemariam Z, Naganuri M, Geddugol BJ, Mesfin F, Befikadu H, et al. Tuberculosis patients are physically challenged and socially isolated: a mixed methods case-control study of health related quality of life in eastern Ethiopia. PLoS One. 2018;13(10). Roba AA, Dasa TT, Weldegebrea F, Asfaw A, Mitiku H, Teklemariam Z, Naganuri M, Geddugol BJ, Mesfin F, Befikadu H, et al. Tuberculosis patients are physically challenged and socially isolated: a mixed methods case-control study of health related quality of life in eastern Ethiopia. PLoS One. 2018;13(10).
38.
go back to reference Laurence YV, Griffiths UK, Vassall A. Costs to health services and the patient of treating tuberculosis: a systematic literature review. PharmacoEconomics. 2015. Laurence YV, Griffiths UK, Vassall A. Costs to health services and the patient of treating tuberculosis: a systematic literature review. PharmacoEconomics. 2015.
39.
go back to reference Fitzpatrick C, Floyd K. A systematic review of the cost and cost effectiveness of treatment for multidrug-resistant tuberculosis. Pharmacoeconomics. 2012;30(1):63–80.CrossRef Fitzpatrick C, Floyd K. A systematic review of the cost and cost effectiveness of treatment for multidrug-resistant tuberculosis. Pharmacoeconomics. 2012;30(1):63–80.CrossRef
40.
go back to reference Fuady A, Houweling TAJ, Mansyur M, Richardus JH. Catastrophic total costs in tuberculosisaffected households and their determinants since Indonesia’s implementation of universal health coverage. Infectious Diseases of Poverty. 2018;7(3). Fuady A, Houweling TAJ, Mansyur M, Richardus JH. Catastrophic total costs in tuberculosisaffected households and their determinants since Indonesia’s implementation of universal health coverage. Infectious Diseases of Poverty. 2018;7(3).
Metadata
Title
Prevalence and associated factors of depression among tuberculosis patients in Eastern Ethiopia
Authors
Tamirat Tesfaye Dasa
Aklilu Abrham Roba
Fitsum Weldegebreal
Frehiwot Mesfin
Abiyot Asfaw
Habtamu Mitiku
Zelalem Teklemariam
Bahubali Jinnappa Geddugol
Mahantash Naganuri
Hilina Befikadu
Eden Tesfaye
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-019-2042-6

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