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Published in: BMC Psychiatry 1/2017

Open Access 01-12-2017 | Research article

The mediational role of physical activity, social contact and stroke on the association between age, education, employment and dementia in an Asian older adult population

Authors: Edimansyah Abdin, Siow Ann Chong, Chao Xu Peh, Janhavi Ajit Vaingankar, Boon Yiang Chua, Swapna Verma, Anitha Jeyagurunathan, Saleha Shafie, Mythily Subramaniam

Published in: BMC Psychiatry | Issue 1/2017

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Abstract

Background

Our study aimed to investigate the pathways by which socio-demographic factors, modifiable health and lifestyle risk factors influence each other, and subsequently, lead to dementia.

Methods

We used data from the Well-being of the Singapore Elderly study, a nationally representative survey of the older adult population aged 60 years and above in Singapore. Dementia diagnosis was established using 10/66 dementia criteria. Structural equation modelling (SEM) without latent variable was applied to confirm the hypothesized model.

Results

The results of SEM supported the hypothesized model (χ 2 = 14.999, df = 10, p = 0.132). The final model showed that those aged 75–84 years and 85 years and over (vs. 60–74 years), having no formal education, who had completed primary or secondary education (vs. completed tertiary), who were homemakers and retired (vs. paid work), and with a history of stroke were directly associated with higher odds of having dementia, while those who had more frequent contact with friends and neighbors as well as being physically active were directly associated with lower odds of having dementia diagnosis. The study also found that physical activity, more frequent contact with friends and stroke played a significant role as mediators in these relationships. The overall pathways model explained 57.7% of the variance in dementia.

Conclusion

Our results suggest that physical activity, social contact and stroke were potential mediators in the relationship between age, education, employment and dementia. Intervention programmes focusing on physical activity such as exercise and social contact may be useful in reducing the risk of dementia among older adults.
Literature
1.
go back to reference Wimo A, Winblad B, Jonsson L. The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement. 2010;6:98–103.CrossRefPubMed Wimo A, Winblad B, Jonsson L. The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement. 2010;6:98–103.CrossRefPubMed
2.
go back to reference ADI. Dementia and risk reduction: an analysis of protective and modifiable factors. In: World Alzheimer Report. London: Alzheimer's Disease International; 2014. ADI. Dementia and risk reduction: an analysis of protective and modifiable factors. In: World Alzheimer Report. London: Alzheimer's Disease International; 2014.
3.
go back to reference Kuiper JS, Zuidersma M, Oude Voshaar RC, Zuidema SU, van den Heuvel ER, Stolk RP, Smidt N. Social relationships and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev. 2015;22:39–57.CrossRefPubMed Kuiper JS, Zuidersma M, Oude Voshaar RC, Zuidema SU, van den Heuvel ER, Stolk RP, Smidt N. Social relationships and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev. 2015;22:39–57.CrossRefPubMed
5.
go back to reference Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and meta-analysis. Alzheimers Dement. 2013;9:63–75. e62CrossRefPubMed Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and meta-analysis. Alzheimers Dement. 2013;9:63–75. e62CrossRefPubMed
6.
go back to reference Strand BH, Langballe EM, Rosness TA, Bergem AL, Engedal K, Nafstad P, Tell GS, Ormstad H, Tambs K, Bjertness E, et al. Age, education and dementia related deaths. The Norwegian Counties Study and The Cohort of Norway. J Neurol Sci. 2014;345:75–82.CrossRefPubMed Strand BH, Langballe EM, Rosness TA, Bergem AL, Engedal K, Nafstad P, Tell GS, Ormstad H, Tambs K, Bjertness E, et al. Age, education and dementia related deaths. The Norwegian Counties Study and The Cohort of Norway. J Neurol Sci. 2014;345:75–82.CrossRefPubMed
7.
go back to reference Meng X, D'Arcy C. Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One. 2012;7:e38268.CrossRefPubMedPubMedCentral Meng X, D'Arcy C. Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One. 2012;7:e38268.CrossRefPubMedPubMedCentral
8.
go back to reference Then FS, Luck T, Angermeyer MC, Riedel-Heller SG. Education as protector against dementia, but what exactly do we mean by education? Age Ageing. 2016; Then FS, Luck T, Angermeyer MC, Riedel-Heller SG. Education as protector against dementia, but what exactly do we mean by education? Age Ageing. 2016;
9.
go back to reference Ojagbemi A, Bello T, Gureje O. Cognitive Reserve, Incident Dementia, and Associated Mortality in the Ibadan Study of Ageing. J Am Geriatr Soc. 2016;64:590–5.CrossRefPubMedPubMedCentral Ojagbemi A, Bello T, Gureje O. Cognitive Reserve, Incident Dementia, and Associated Mortality in the Ibadan Study of Ageing. J Am Geriatr Soc. 2016;64:590–5.CrossRefPubMedPubMedCentral
10.
go back to reference Ngandu T, von Strauss E, Helkala EL, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Education and dementia: what lies behind the association? Neurology. 2007;69:1442–50.CrossRefPubMed Ngandu T, von Strauss E, Helkala EL, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Education and dementia: what lies behind the association? Neurology. 2007;69:1442–50.CrossRefPubMed
11.
go back to reference Valenzuela MJ, Sachdev P. Brain reserve and dementia: a systematic review. Psychol Med. 2006;36:441–54.CrossRefPubMed Valenzuela MJ, Sachdev P. Brain reserve and dementia: a systematic review. Psychol Med. 2006;36:441–54.CrossRefPubMed
12.
go back to reference Demirovic J, Prineas R, Loewenstein D, Bean J, Duara R, Sevush S, Szapocznik J. Prevalence of dementia in three ethnic groups: the South Florida program on aging and health. Ann Epidemiol. 2003;13:472–8.CrossRefPubMed Demirovic J, Prineas R, Loewenstein D, Bean J, Duara R, Sevush S, Szapocznik J. Prevalence of dementia in three ethnic groups: the South Florida program on aging and health. Ann Epidemiol. 2003;13:472–8.CrossRefPubMed
13.
go back to reference Steenland K, Goldstein FC, Levey A, Wharton W. A Meta-Analysis of Alzheimer's Disease Incidence and Prevalence Comparing African-Americans and Caucasians. J Alzheimers Dis. 2015;50:71–6.CrossRef Steenland K, Goldstein FC, Levey A, Wharton W. A Meta-Analysis of Alzheimer's Disease Incidence and Prevalence Comparing African-Americans and Caucasians. J Alzheimers Dis. 2015;50:71–6.CrossRef
14.
go back to reference Rolland Y. Abellan van Kan G, Vellas B. Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives. J Am Med Dir Assoc. 2008;9:390–405.CrossRefPubMed Rolland Y. Abellan van Kan G, Vellas B. Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives. J Am Med Dir Assoc. 2008;9:390–405.CrossRefPubMed
15.
go back to reference Stephan BC, Brayne C. Vascular factors and prevention of dementia. Int Rev Psychiatry. 2008;20:344–56.CrossRefPubMed Stephan BC, Brayne C. Vascular factors and prevention of dementia. Int Rev Psychiatry. 2008;20:344–56.CrossRefPubMed
16.
go back to reference Stewart R, Prince M, Mann A. Vascular risk factors and Alzheimer's disease. Aust N Z J Psychiatry. 1999;33:809–13.CrossRefPubMed Stewart R, Prince M, Mann A. Vascular risk factors and Alzheimer's disease. Aust N Z J Psychiatry. 1999;33:809–13.CrossRefPubMed
17.
go back to reference Prince M, Cullen M, Mann A. Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial. Neurology. 1994;44:97–104.CrossRefPubMed Prince M, Cullen M, Mann A. Risk factors for Alzheimer's disease and dementia: a case-control study based on the MRC elderly hypertension trial. Neurology. 1994;44:97–104.CrossRefPubMed
18.
go back to reference Strand BH, Langballe EM, Rosness TA, Engedal K, Bjertness E. Does midlife obesity really lower dementia risk? Lancet Diabetes Endocrinol. 2015;3:498–9.CrossRefPubMed Strand BH, Langballe EM, Rosness TA, Engedal K, Bjertness E. Does midlife obesity really lower dementia risk? Lancet Diabetes Endocrinol. 2015;3:498–9.CrossRefPubMed
19.
go back to reference Hayden KM, Zandi PP, Lyketsos CG, Khachaturian AS, Bastian LA, Charoonruk G, Tschanz JT, Norton MC, Pieper CF, Munger RG, et al. Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study. Alzheimer Dis Assoc Disord. 2006;20:93–100.CrossRefPubMed Hayden KM, Zandi PP, Lyketsos CG, Khachaturian AS, Bastian LA, Charoonruk G, Tschanz JT, Norton MC, Pieper CF, Munger RG, et al. Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study. Alzheimer Dis Assoc Disord. 2006;20:93–100.CrossRefPubMed
21.
go back to reference Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Imbimbo BP, Santamato A, Vendemiale G, Seripa D, Pilotto A, et al. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry. 2010;18:98–116.CrossRefPubMed Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Imbimbo BP, Santamato A, Vendemiale G, Seripa D, Pilotto A, et al. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry. 2010;18:98–116.CrossRefPubMed
22.
23.
go back to reference Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds 3rd CF. Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry. 2013;202:329–35.CrossRefPubMedPubMedCentral Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds 3rd CF. Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry. 2013;202:329–35.CrossRefPubMedPubMedCentral
24.
go back to reference Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58:498–504.CrossRefPubMed Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58:498–504.CrossRefPubMed
25.
go back to reference Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, et al. The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. Eur J Epidemiol. 2016;31:267–74.CrossRefPubMed Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, et al. The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. Eur J Epidemiol. 2016;31:267–74.CrossRefPubMed
26.
go back to reference Groot C, Hooghiemstra AM, Raijmakers PG, van Berckel BN, Scheltens P, Scherder EJ, van der Flier WM, Ossenkoppele R. The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials. Ageing Res Rev. 2016;25:13–23.CrossRefPubMed Groot C, Hooghiemstra AM, Raijmakers PG, van Berckel BN, Scheltens P, Scherder EJ, van der Flier WM, Ossenkoppele R. The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials. Ageing Res Rev. 2016;25:13–23.CrossRefPubMed
27.
go back to reference Brett L, Traynor V, Stapley P. Effects of Physical Exercise on Health and Well-Being of Individuals Living With a Dementia in Nursing Homes: A Systematic Review. J Am Med Dir Assoc. 2016;17:104–16.CrossRefPubMed Brett L, Traynor V, Stapley P. Effects of Physical Exercise on Health and Well-Being of Individuals Living With a Dementia in Nursing Homes: A Systematic Review. J Am Med Dir Assoc. 2016;17:104–16.CrossRefPubMed
28.
go back to reference Rosness TA, Strand BH, Bergem AL, Engedal K, Bjertness E. Associations between Physical Activity in Old Age and Dementia-Related Mortality: A Population-Based Cohort Study. Dement Geriatr Cogn Dis Extra. 2014;4:410–8.CrossRefPubMedPubMedCentral Rosness TA, Strand BH, Bergem AL, Engedal K, Bjertness E. Associations between Physical Activity in Old Age and Dementia-Related Mortality: A Population-Based Cohort Study. Dement Geriatr Cogn Dis Extra. 2014;4:410–8.CrossRefPubMedPubMedCentral
29.
go back to reference Pillai JA, Verghese J. Social networks and their role in preventing dementia. Indian J Psychiatry. 2009;51(Suppl 1):S22–8.PubMedPubMedCentral Pillai JA, Verghese J. Social networks and their role in preventing dementia. Indian J Psychiatry. 2009;51(Suppl 1):S22–8.PubMedPubMedCentral
30.
go back to reference Crooks V, Lubben J, Petitti D, Little D, Chiu V. Social Network, Cognitive Function, and Dementia Incidence Among Elderly Women. Am J Public Health. 2008;98:1221–7.CrossRefPubMedPubMedCentral Crooks V, Lubben J, Petitti D, Little D, Chiu V. Social Network, Cognitive Function, and Dementia Incidence Among Elderly Women. Am J Public Health. 2008;98:1221–7.CrossRefPubMedPubMedCentral
31.
go back to reference Singapore Department of Statistics: Yearbook of statistics Singapore; 2014. Singapore Department of Statistics: Yearbook of statistics Singapore; 2014.
32.
go back to reference Subramaniam M, Chong SA, Vaingankar JA, Abdin E, Chua BY, Chua HC, Eng GK, Heng D, Hia SB, Huang W, et al. Prevalence of dementia in people aged 60 years and above: results from the WiSE study. J Alzheimers Dis. 2015;45(4):1127–38.PubMed Subramaniam M, Chong SA, Vaingankar JA, Abdin E, Chua BY, Chua HC, Eng GK, Heng D, Hia SB, Huang W, et al. Prevalence of dementia in people aged 60 years and above: results from the WiSE study. J Alzheimers Dis. 2015;45(4):1127–38.PubMed
33.
go back to reference Prince M, Ferri CP, Acosta D, Albanese E, Arizaga R, Dewey M, Gavrilova SI, Guerra M, Huang Y, Jacob KS, et al. The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health. 2007;7:165.CrossRefPubMedPubMedCentral Prince M, Ferri CP, Acosta D, Albanese E, Arizaga R, Dewey M, Gavrilova SI, Guerra M, Huang Y, Jacob KS, et al. The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health. 2007;7:165.CrossRefPubMedPubMedCentral
34.
go back to reference Prince M, Acosta D, Chiu H, Scazufca M, Varghese M, Dementia RG. Dementia diagnosis in developing countries: a cross-cultural validation study. Lancet. 2003;361:909–17.CrossRefPubMed Prince M, Acosta D, Chiu H, Scazufca M, Varghese M, Dementia RG. Dementia diagnosis in developing countries: a cross-cultural validation study. Lancet. 2003;361:909–17.CrossRefPubMed
35.
go back to reference Copeland JR, Dewey ME, Griffiths-Jones HM. A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med. 1986;16:89–99.CrossRefPubMed Copeland JR, Dewey ME, Griffiths-Jones HM. A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med. 1986;16:89–99.CrossRefPubMed
36.
go back to reference Hall KS, Hendrie HC, Brittain HM, Norton JA. The development of a dementia screening interview in two distinct languages. Int J Methods Psychiatr Res. 1993;3:1–28. Hall KS, Hendrie HC, Brittain HM, Norton JA. The development of a dementia screening interview in two distinct languages. Int J Methods Psychiatr Res. 1993;3:1–28.
37.
go back to reference Ganguli M, Chandra V, Gilby JE, Ratcliff G, Sharma SD, Pandav R, Seaberg EC, Belle S. Cognitive test performance in a community-based nondemented elderly sample in rural India: the Indo-U.S. Cross-National Dementia Epidemiology Study. Int Psychogeriatr. 1996;8:507–24.CrossRefPubMed Ganguli M, Chandra V, Gilby JE, Ratcliff G, Sharma SD, Pandav R, Seaberg EC, Belle S. Cognitive test performance in a community-based nondemented elderly sample in rural India: the Indo-U.S. Cross-National Dementia Epidemiology Study. Int Psychogeriatr. 1996;8:507–24.CrossRefPubMed
38.
go back to reference Prince MJ, de Rodriguez JL, Noriega L, Lopez A, Acosta D, Albanese E, Arizaga R, Copeland JR, Dewey M, Ferri CP, et al. The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study. BMC Public Health. 2008;8:219.CrossRefPubMedPubMedCentral Prince MJ, de Rodriguez JL, Noriega L, Lopez A, Acosta D, Albanese E, Arizaga R, Copeland JR, Dewey M, Ferri CP, et al. The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study. BMC Public Health. 2008;8:219.CrossRefPubMedPubMedCentral
39.
go back to reference Reichenheim ME, Moraes CL, Lopes CS, Lobato G. The role of intimate partner violence and other health-related social factors on postpartum common mental disorders: a survey-based structural equation modeling analysis. BMC Public Health. 2014;14:427.CrossRefPubMedPubMedCentral Reichenheim ME, Moraes CL, Lopes CS, Lobato G. The role of intimate partner violence and other health-related social factors on postpartum common mental disorders: a survey-based structural equation modeling analysis. BMC Public Health. 2014;14:427.CrossRefPubMedPubMedCentral
40.
go back to reference Muthen B, Asparouhov OK. Causal Effects in Mediation Modeling: An Introduction With Applications to Latent Variables. Struct Equ Model Multidiscip J. 2015;22:12–23.CrossRef Muthen B, Asparouhov OK. Causal Effects in Mediation Modeling: An Introduction With Applications to Latent Variables. Struct Equ Model Multidiscip J. 2015;22:12–23.CrossRef
41.
go back to reference Beauducel A, Herzberg PY. On the performance of maximum likelihood versus means and variance adjusted weighted least squares estimation in CFA. Struct Equ Model. 2006;13:186–203.CrossRef Beauducel A, Herzberg PY. On the performance of maximum likelihood versus means and variance adjusted weighted least squares estimation in CFA. Struct Equ Model. 2006;13:186–203.CrossRef
42.
go back to reference Hu L, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equ Model. 1999;6:1–55.CrossRef Hu L, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equ Model. 1999;6:1–55.CrossRef
43.
go back to reference Seow SW, Subramaniam M, Abdin E, Vaingankar JA, Chong SA. Hypertension and its associated risks among Singapore elderly residential population. J Clin Gerontol Geriatr 2015;2015(Issue 4):125–132. Seow SW, Subramaniam M, Abdin E, Vaingankar JA, Chong SA. Hypertension and its associated risks among Singapore elderly residential population. J Clin Gerontol Geriatr 2015;2015(Issue 4):125–132.
44.
go back to reference Chang M, Jonsson P, Snaedal J, Bjornsson S, Saczynski J, Aspelund T, Eiriksdottir G, Jonsdottir M, Lopez O, Harris T, et al. The effect of midlife physical activity on cognitive function among older adults: AGES--Reykjavik Study. J Gerontol A Biol Sci Med Sci. 2010;65:1369–74.CrossRefPubMed Chang M, Jonsson P, Snaedal J, Bjornsson S, Saczynski J, Aspelund T, Eiriksdottir G, Jonsdottir M, Lopez O, Harris T, et al. The effect of midlife physical activity on cognitive function among older adults: AGES--Reykjavik Study. J Gerontol A Biol Sci Med Sci. 2010;65:1369–74.CrossRefPubMed
45.
go back to reference Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, Gach HM, Longstreth Jr WT, Teverovskiy L, Kuller LH, Carmichael OT, et al. Physical activity, body mass index, and brain atrophy in Alzheimer's disease. Neurobiol Aging. 2015;36(Suppl 1):S194–202.CrossRefPubMed Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, Gach HM, Longstreth Jr WT, Teverovskiy L, Kuller LH, Carmichael OT, et al. Physical activity, body mass index, and brain atrophy in Alzheimer's disease. Neurobiol Aging. 2015;36(Suppl 1):S194–202.CrossRefPubMed
47.
go back to reference Teri L, Gibbons LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, Kukull WA, LaCroix AZ, McCormick W, Larson EB. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003;290:2015–22.CrossRefPubMed Teri L, Gibbons LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, Kukull WA, LaCroix AZ, McCormick W, Larson EB. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003;290:2015–22.CrossRefPubMed
48.
go back to reference Blumenthal JA, Babyak MA, Moore KA, Craighead WE, Herman S, Khatri P, Waugh R, Napolitano MA, Forman LM, Appelbaum M, et al. Effects of exercise training on older patients with major depression. Arch Intern Med. 1999;159:2349–56.CrossRefPubMed Blumenthal JA, Babyak MA, Moore KA, Craighead WE, Herman S, Khatri P, Waugh R, Napolitano MA, Forman LM, Appelbaum M, et al. Effects of exercise training on older patients with major depression. Arch Intern Med. 1999;159:2349–56.CrossRefPubMed
49.
go back to reference Mather AS, Rodriguez C, Guthrie MF, McHarg AM, Reid IC, McMurdo ME. Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: randomised controlled trial. Br J Psychiatry. 2002;180:411–5.CrossRefPubMed Mather AS, Rodriguez C, Guthrie MF, McHarg AM, Reid IC, McMurdo ME. Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: randomised controlled trial. Br J Psychiatry. 2002;180:411–5.CrossRefPubMed
50.
go back to reference Zhong BL, Chen SL, Tu X, Conwell Y. Loneliness and Cognitive Function in Older Adults: Findings From the Chinese Longitudinal Healthy Longevity Survey. J Gerontol B Psychol Sci Soc Sci. 2017;72:120–8.CrossRefPubMed Zhong BL, Chen SL, Tu X, Conwell Y. Loneliness and Cognitive Function in Older Adults: Findings From the Chinese Longitudinal Healthy Longevity Survey. J Gerontol B Psychol Sci Soc Sci. 2017;72:120–8.CrossRefPubMed
Metadata
Title
The mediational role of physical activity, social contact and stroke on the association between age, education, employment and dementia in an Asian older adult population
Authors
Edimansyah Abdin
Siow Ann Chong
Chao Xu Peh
Janhavi Ajit Vaingankar
Boon Yiang Chua
Swapna Verma
Anitha Jeyagurunathan
Saleha Shafie
Mythily Subramaniam
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2017
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-017-1272-8

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