Top

Published in:

Open Access 01-12-2007 | Study protocol

The protocols for the 10/66 dementia research group population-based research programme

Authors: Martin Prince, Cleusa P Ferri, Daisy Acosta, Emiliano Albanese, Raul Arizaga, Michael Dewey, Svetlana I Gavrilova, Mariella Guerra, Yueqin Huang, KS Jacob, ES Krishnamoorthy, Paul McKeigue, Juan Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Renata MM Sousa, Robert Stewart, Richard Uwakwe

Published in: BMC Public Health | Issue 1/2007

Abstract

Background

Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an increasing number of people with dementia. The 10/66 Dementia Research Group's title refers to the 66% of people with dementia that live in developing countries and the less than one tenth of population-based research carried out in those settings. This paper describes the protocols for the 10/66 population-based and intervention studies that aim to redress this imbalance.

Methods/design

Cross-sectional comprehensive one phase surveys have been conducted of all residents aged 65 and over of geographically defined catchment areas in ten low and middle income countries (India, China, Nigeria, Cuba, Dominican Republic, Brazil, Venezuela, Mexico, Peru and Argentina), with a sample size of between 1000 and 3000 (generally 2000). Each of the studies uses the same core minimum data set with cross-culturally validated assessments (dementia diagnosis and subtypes, mental disorders, physical health, anthropometry, demographics, extensive non communicable disease risk factor questionnaires, disability/functioning, health service utilisation, care arrangements and caregiver strain). Nested within the population based studies is a randomised controlled trial of a caregiver intervention for people with dementia and their families (ISRCTN41039907; ISRCTN41062011; ISRCTN95135433; ISRCTN66355402; ISRCTN93378627; ISRCTN94921815). A follow up of 2.5 to 3.5 years will be conducted in 7 countries (China, Cuba, Dominican Republic, Venezuela, Mexico, Peru and Argentina) to assess risk factors for incident dementia, stroke and all cause and cause-specific mortality; verbal autopsy will be used to identify causes of death.

Discussion

The 10/66 DRG baseline population-based studies are nearly complete. The incidence phase will be completed in 2009. All investigators are committed to establish an anonymised file sharing archive with monitored public access. Our aim is to create an evidence base to empower advocacy, raise awareness about dementia, and ensure that the health and social care needs of older people are anticipated and met.

Available only for authorised users

Group TDR: Dementia in Developing Countries. A preliminary consensus statement from the 10/66 Dementia Research Group. International Journal of Geriatric Psychiatry. 2000, 15: 14-20. 10.1002/(SICI)1099-1166(200001)15:1<14::AID-GPS70>3.0.CO;2-8.

Group TDR: Methodological issues in population-based research into dementia in developing countries. A position paper from the 10/66 Dementia Research Group. International Journal of Geriatric Psychiatry. 2000, 15: 21-30. 10.1002/(SICI)1099-1166(200001)15:1<21::AID-GPS71>3.0.CO;2-5.

Group TDR: Alzheimer Disease International. 2007, [http://www.alz.co.uk/1066]

Prince M, Graham N, Brodaty H, Rimmer E, Varghese M, Chiu H, Acosta D, Scazufca M: Alzheimer Disease International's 10/66 Dementia Research Group - one model for action research in developing countries. Int J Geriatr Psychiatry. 2004, 19: 178-181. 10.1002/gps.1059.PubMed

Prince M, Acosta D, Chiu H, Scazufca M, Varghese M: Dementia diagnosis in developing countries: a cross-cultural validation study. The Lancet. 2003, 361: 909-917. 10.1016/S0140-6736(03)12772-9.

Liu SI, Prince M, Chiu MJ, Chen TF, Sun YW, Yip PK: Validity and reliability of a Taiwan Chinese version of the community screening instrument for dementia. Am J Geriatr Psychiatry. 2005, 13: 581-588. 10.1176/appi.ajgp.13.7.581.PubMed

Choo WY, Low WY, Karina R, Poip PJ, Ebenezer E, Prince MJ: Social support and burden among caregivers of patients with dementia in Malaysia. Asia Pac J Public Health. 2003, 15: 23-29.PubMed

Dias A, Samuel R, Patel V, Prince M, Parameshwaran R, Krishnamoorthy ES: The impact associated with caring for a person with dementia: a report from the 10/66 Dementia Research Group's Indian network. Int J Geriatr Psychiatry. 2004, 19: 182-184. 10.1002/gps.1016.PubMed

Prince M, Group DR: Care arrangements for people with dementia in developing countries. International Journal of Geriatric Psychiatry. 2004, 19: 170-177. 10.1002/gps.1059.PubMed

10.

Patel V, Prince M: Ageing and mental health in a developing country: who cares? Qualitative studies from Goa, India. Psychological Medicine. 2001, 31: 29-38. 10.1017/S0033291799003098.PubMed

11.

Shaji KS, Smitha K, Praveen Lal K, Prince M: Caregivers Of Patients With Alzheimer's Disease : A Qualitative Study From The Indian 10/66 Dementia Research Network. International Journal of Geriatric Psychiatry. 2002, 18: 1-6. 10.1002/gps.649.

12.

Ferri CP, Ames D, Prince M: Behavioral and psychological symptoms of dementia in developing countries. Int Psychogeriatr. 2004, 16: 441-459. 10.1017/S1041610204000833.PubMed

13.

Ramos-Cerqueira AT, Torres AR, Crepaldi AL, Oliveira NI, Scazufca M, Menezes PR, Prince M: Identification of dementia cases in the community: a Brazilian experience. J Am Geriatr Soc. 2005, 53: 1738-1742.PubMed

14.

Shaji KS, Arun Kishore NR, Lal KP, Prince M: Revealing a hidden problem. An evaluation of a community dementia case-finding program from the Indian 10/66 dementia research network. International Journal of Geriatric Psychiatry. 2002, 17: 222-225. 10.1002/gps.553.PubMed

15.

World Population Prospects: The 2002 Revision - Highlights. 2003, New York, United Nations

16.

Fuster V, Voute J: MDGs: chronic diseases are not on the agenda. Lancet. 2005, 366: 1512-1514. 10.1016/S0140-6736(05)67610-6.PubMed

17.

Yusuf S, Reddy S, Ounpuu S, Anand S: Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. [Review] [44 refs]. Circulation. 2001, 104: 2746-2753.PubMed

18.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, INTERHEART S: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.[see comment]. Lancet. 2004, 364: 937-952. 10.1016/S0140-6736(04)17018-9.PubMed

19.

Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M: Global prevalence of dementia: a Delphi consensus study. Lancet. 2005, 366: 2112-2117. 10.1016/S0140-6736(05)67889-0.PubMedPubMedCentral

20.

The Atlas of Heart Disease and Stroke. Edited by: Mackay J and Mensah G. 2004, Geneva, World Health Organization

21.

Jr HE, Caramelli P, Silveira AS, Nitrini R: Epidemiologic survey of dementia in a community-dwelling Brazilian population. Alzheimer Disease & Associated Disorders. 2002, 16: 103-108. 10.1097/00002093-200204000-00007.

22.

Nitrini R, Caramelli P, Jr HE, Bahia VS, Caixeta LF, Radanovic M, Anghinah R, Charchat-Fichman H, Porto CS, Carthery MT, Hartmann AP, Huang N, Smid J, Lima EP, Takada LT, Takahashi DY: Incidence of dementia in a community-dwelling Brazilian population. Alzheimer Disease & Associated Disorders. 2004, 18: 241-246.

23.

Rosselli D, Ardila A, Pradilla G, Morillo L, Bautista L, Rey O, Camacho M: [The Mini-Mental State Examination as a selected diagnostic test for dementia: a Colombian population study. GENECO]. Rev Neurol. 2000, 30: 428-432.PubMed

24.

Chandra V, Ganguli M, Pandav R, Johnston J, Belle S, DeKosky ST: Prevalence of Alzheimer's disease and other dementias in rural India. The Indo-US study. Neurology. 1998, 51: 1000-1008.PubMed

25.

Hendrie HC, Osuntokun BO, Hall KS, Ogunniyi AO, Hui SL, Unverzagt FW, Gureje O, Rodenberg CA, Baiyewu O, Musick BS, et al: Prevalence of Alzheimer's disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatry. 1995, 152: 1485-1492.PubMed

26.

Hendrie HC, Ogunniyi A, Hall KS, Baiyewu O, Unverzagt FW, Gureje O, Gao S, Evans RM, Ogunseyinde AO, Adeyinka AO, Musick B, Hui SL: Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana. JAMA. 2001, 285: 739-747. 10.1001/jama.285.6.739.PubMed

27.

Hendrie HC, Hall KS, Ogunniyi A, Gao S: Alzheimer's disease, genes, and environment: the value of international studies. Can J Psychiatry. 2004, 49: 92-99.PubMed

28.

Breteler MM, Bots ML, Ott A, Hofman A: Risk factors for vascular disease and dementia. [Review] [57 refs]. Haemostasis 28(3-4):167-73,. 1998, Aug.

29.

Chandra V, Pandav R: Gene-Environment Interaction in Alzheimer's Disease: A Potential Role for Cholesterol. Neuroepidemiology. 1998, 17: 225-232. 10.1159/000026175.PubMed

30.

Pandav RS, Chandra V, Dodge HH, DeKosky ST, Ganguli M: Hemoglobin levels and Alzheimer disease: an epidemiologic study in India. American Journal of Geriatric Psychiatry 12(5):523-6,. 2004, 12 (5): 523-526. 10.1176/appi.ajgp.12.5.523.

31.

Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993, 270: 2693-2698. 10.1001/jama.270.22.2693.PubMed

32.

Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman J, Graham I: Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation. 1998, 97: 437-443.PubMed

33.

Allen LH: Folate and vitamin B12 status in the Americas. Nutr Rev. 2004, 62: S29-S33. 10.1301/nr.2004.jun.S29-S33.PubMed

34.

Garcia-Casal MN, Osorio C, Landaeta M, Leets I, Matus P, Fazzino F, Marcos E: High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela. Eur J Clin Nutr. 2005, 59: 1064-1070. 10.1038/sj.ejcn.1602212.PubMed

35.

Arnaud J, Fleites-Mestre P, Chassagne M, Verdura T, Garcia G, Hernandez-Fernandez T, Gautier H, Favier A, Perez-Cristia R, Barnouin J: Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic. Br J Nutr. 2001, 85: 741-748.PubMed

36.

Pretell EA, Delange F, Hostalek U, Corigliano S, Barreda L, Higa AM, Altschuler N, Barragan D, Cevallos JL, Gonzales O, Jara JA, Medeiros-Neto G, Montes JA, Muzzo S, Pacheco VM, Cordero L: Iodine nutrition improves in Latin America. Thyroid. 2004, 14: 590-599. 10.1089/1050725041692909.PubMed

37.

Petri Nahas EA, Nahas-Neto J, Ferreira Santos PEM, Ferreira da Silva Mazeto GM, Dalben I, Pontes A, Traiman P: Prevalence of subclinical hypothyroidism and its effects on lipidic profile and bone mineral density in postmenopausal women. Revista Brasileirade Ginecologia e Obstetrica. 2005, 27:

38.

Division UNS: UN Statistics Division Demographic and Social Statistics. 1948, New York, United Nations

39.

McGee MA, Brayne C: The impact on prevalence of dementia in the oldest age groups of differential mortality patterns: a deterministic approach. International Journal of Epidemiology 27(1):87-90,. 1998

40.

Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, van Harskamp F, van Duijn CN, Van Broeckhoven C, Grobbee DE: Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet. 1997, 349: 151-154. 10.1016/S0140-6736(96)09328-2.PubMed

41.

Ott A, Slooter AJC, Hofman A, van Harskamp F, Witteman JCM, Van Broeckhoven C, van Duijn CM, Breteler MMB: Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study. Lancet. 1998, 351: 1841-1843. 10.1016/S0140-6736(97)07541-7.

42.

Juan D, Zhou DH, Li J, Wang JY, Gao C, Chen M: A 2-year follow-up study of cigarette smoking and risk of dementia. Eur J Neurol. 2004, 11: 277-282. 10.1046/j.1468-1331.2003.00779.x.PubMed

43.

Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R: Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology. 2005, 65: 545-551. 10.1212/01.wnl.0000172914.08967.dc.PubMedPubMedCentral

44.

Tyas SL, White LR, Petrovitch H, Webster RG, Foley DJ, Heimovitz HK, Launer LJ: Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study. Neurobiol Aging. 2003, 24: 589-596. 10.1016/S0197-4580(02)00156-2.PubMed

45.

Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K: Midlife cardiovascular risk factors and risk of dementia in late life. Neurology. 2005, 64: 277-281.PubMed

46.

Hill G, Connelly J, Hebert R, Lindsay J, Millar W: Neyman's bias re-visited. J Clin Epidemiol. 2003, 56: 293-296. 10.1016/S0895-4356(02)00571-1.PubMed

47.

Ott A, Stolk RP, van HF, Pols HA, Hofman A, Breteler MM: Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology. 1999, 53: 1937-1942.PubMed

48.

Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, Persson G, Oden A, Svanborg A: 15-year longitudinal study of blood pressure and dementia [see comments]. Lancet. 1996, 347: 1141-1145. 10.1016/S0140-6736(96)90608-X.PubMed

49.

Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A: Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ. 2001, 322: 1447-1451. 10.1136/bmj.322.7300.1447.PubMedPubMedCentral

50.

Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB: The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004, 292: 2237-2242. 10.1001/jama.292.18.2237.PubMed

51.

Abbatecola AM, Paolisso G, Lamponi M, Bandinelli S, Lauretani F, Launer L, Ferrucci L: Insulin resistance and executive dysfunction in older persons. J Am Geriatr Soc. 2004, 52: 1713-1718. 10.1111/j.1532-5415.2004.52466.x.PubMed

52.

Yip AG, Brayne C, Matthews FE: Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age Ageing. 2006

53.

Bursi F, Rocca WA, Killian JM, Weston SA, Knopman DS, Jacobsen SJ, Roger VL: Heart Disease and Dementia: A Population-based Study. Am J Epidemiol. 2006, 163: 135-141. 10.1093/aje/kwj025.PubMed

54.

Casserly I, Topol E: Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet. 2004, 363: 1139-1146. 10.1016/S0140-6736(04)15900-X.PubMed

55.

Luchsinger JA, Mayeux R: Dietary factors and Alzheimer's disease. Lancet Neurol. 2004, 3: 579-587. 10.1016/S1474-4422(04)00878-6.PubMed

56.

Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Porcellini E, Licastro F: Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr. 2005, 82: 636-643.PubMed

57.

Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L: Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology. 2001, 56: 1188-1194.PubMed

58.

Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002, 346: 476-483. 10.1056/NEJMoa011613.PubMed

59.

Crystal HA, Ortof E, Frishman WH, Gruber A, Hershman D, Aronson M: Serum vitamin B12 levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study. J Am Geriatr Soc. 1994, 42: 933-936.PubMed

60.

Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004, 291: 228-238. 10.1001/jama.291.2.228.PubMed

61.

Ganguli M, Burmeister LA, Seaberg EC, Belle S, DeKosky ST: Association between dementia and elevated TSH: a community-based study. Biol Psychiatry. 1996, 40: 714-725. 10.1016/0006-3223(95)00489-0.PubMed

62.

Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM: Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin Endocrinol (Oxf). 2000, 53: 733-737. 10.1046/j.1365-2265.2000.01146.x.

63.

Gureje O, Ogunniyi A, Baiyewu O, Price B, Unverzagt FW, Evans RM, Smith-Gamble V, Lane KA, Gao S, Hall KS, Hendrie HC, Murrell JR: APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians. Ann Neurol. 2006, 59: 182-185. 10.1002/ana.20694.PubMedPubMedCentral

64.

Kalaria RN, Ogeng'o JA, Patel NB, Sayi JG, Kitinya JN, Chande HM, Matuja WB, Mtui EP, Kimani JK, Premkumar DR, Koss E, Gatere S, Friedland RP: Evaluation of risk factors for Alzheimer's disease in elderly east Africans. Brain Res Bull. 1997, 44: 573-577. 10.1016/S0361-9230(97)00310-9.PubMed

65.

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. [see comments.]. JAMA. 1997, 278: 1349-1356. 10.1001/jama.278.16.1349.PubMed

66.

Ganguli M, Chandra V, Kamboh MI, Johnston JM, Dodge HH, Thelma BK, Juyal RC, Pandav R, Belle SH, DeKosky ST: Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study. Arch Neurol. 2000, 57: 824-830. 10.1001/archneur.57.6.824.PubMed

67.

Stewart JA, Dundas R, Howard RS, Rudd AG, Wolfe CD: Ethnic differences in incidence of stroke: prospective study with stroke register. BMJ. 1999, 318: 967-971.PubMedPubMedCentral

68.

Sacco RL, Boden-Albala B, Gan R, Chen X, Kargman DE, Shea S, Paik MC, Hauser WA: Stroke incidence among white, black, and Hispanic residents of an urban community: the Northern Manhattan Stroke Study. Am J Epidemiol. 1998, 147: 259-268.PubMed

69.

White H, Boden-Albala B, Wang C, Elkind MS, Rundek T, Wright CB, Sacco RL: Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study. Circulation. 2005, 111: 1327-1331. 10.1161/01.CIR.0000157736.19739.D0.PubMed

70.

Chaturvedi N: Ethnic differences in cardiovascular disease. Heart. 2003, 89: 681-686. 10.1136/heart.89.6.681.PubMedPubMedCentral

71.

Sacco RL, Boden-Albala B, Abel G, Lin IF, Elkind M, Hauser WA, Paik MC, Shea S: Race-ethnic disparities in the impact of stroke risk factors: the northern Manhattan stroke study. Stroke. 2001, 32: 1725-1731.PubMed

72.

McKeigue PM: Prospects for admixture mapping of complex traits. Am J Hum Genet. 2005, 76: 1-7. 10.1086/426949.PubMed

73.

Hoggart CJ, Shriver MD, Kittles RA, Clayton DG, McKeigue PM: Design and analysis of admixture mapping studies. Am J Hum Genet. 2004, 74: 965-978. 10.1086/420855.PubMedPubMedCentral

74.

Copeland JRM, Dewey ME, Griffith-Jones HM: A computerised psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychological Medicine. 1986, 16: 89-99.PubMed

75.

Hall KS, Hendrie HH, Brittain HM, Norton JA, Rodgers DD, Prince CS, Pillay N, Blue AW, Kaufert JN, Nath A, Shelton P, Postl BD, Osuntokun BO: The development of a dementia screeing interview in two distinct languages. International Journal of Methods in Psychiatric Research. 1993, 3: 1-28.

76.

Ganguli M., Chandra V., Gilbey J.: Cognitive test performance in a community-based non demented elderly sample in rural India: the Indo-US cross national dementia epidemiology study. International Psychogeriatrics. 1996, 8: 507-524. 10.1017/S1041610296002852.PubMed

77.

Dewey ME, Copeland JR: Diagnosis of dementia from the history and aetiology schedule. International Journal of Geriatric Psychiatry. 2001, 16: 912-917. 10.1002/gps.446.PubMed

78.

Broe GA, Akhtar AJ, Andrews GR, Caird FI, Gilmore AJ, McLennan WJ: Neurological disorders in the elderly at home. J Neurol Neurosurg Psychiatry. 1976, 39: 361-366.

79.

Broe GA, Jorm AF, Creasey H, Grayson D, Edelbrock D, Waite LM, Bennett H, Cullen JS, Casey B: Impact of chronic systemic and neurological disorders on disability, depression and life satisfaction [published erratum appears in Int J Geriatr Psychiatry 1999 Jun;14(6):497-8]. International Journal of Geriatric Psychiatry. 1998, 13: 667-673. 10.1002/(SICI)1099-1166(1998100)13:10<667::AID-GPS839>3.0.CO;2-G.PubMed

80.

Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, Lopez OL, DeKosky ST: Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000, 12: 233-239.PubMed

81.

Association. AP: Diagnostic and Statistical Manual of Mental Disorders. 1994, Washington DC, AMA, 4

82.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS- ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984, 34: 939-944.PubMed

83.

Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A: Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993, 43: 250-260.PubMed

84.

McKeith IG, Perry RH, Fairbairn AF, Jabeen S, Perry EK: Operational criteria for senile dementia of Lewy body type (SDLT). Psychol Med. 1992, 22: 911-922.PubMed

85.

Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De TG, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De L, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ, Reich D: A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet. 2004, 74: 1001-1013. 10.1086/420856.PubMedPubMedCentral

86.

Duke University Centre for the Study of Aging and Human Development.: Multidimensional Functional Assessment: The OARS Methodology. 1978, Duke University, Durham NC

87.

Rehm J, Ustun TB, Saxena S: On the development and psychometric testing of the WHO screening instrument to assess disablement in the general population. International Journal of Methods in Psychiatric Research. 2000, 8: 110-122. 10.1002/mpr.61.

88.

Chisholm D, Knapp MRJ, Knudsen HC, Amaddeo F, Gaite L, Van Wijngaarden B: Client Socio-Demographic and Service Receipt Inventory - European Version: development of an instrument for international research. EPSILON study 5. British Journal of Psychiatry. 2000, 117: s28-s33. 10.1192/bjp.177.39.s28.

89.

Gilleard CJ, Belford H, Gilleard E, Whittick JE, Gledhill K: Emotional distress amongst the supporters of the elderly mentally infirm. Br J Psychiatry. 1984, 145: 172-177.PubMed

90.

Davis KL, Marin DB, Kane R, Patrick D, Peskind ER, Raskind MA, Puder KL: The Caregiver Activity Survey (CAS): development and validation of a new measure for caregivers of persons with Alzheimer's disease. Int J Geriatr Psychiatry. 1997, 12: 978-988. 10.1002/(SICI)1099-1166(199710)12:10<978::AID-GPS659>3.0.CO;2-1.PubMed

91.

Whitlatch CJ, Zarit SH, von Eye A: Efficacy of interventions with caregivers: a reanalysis. Gerontologist. 1991, 31: 9-14.PubMed

92.

Zarit SH, Reever KE, Bach-Peterson J: Relatives of the impaired elderly: correlates of feelings of burden. The Gerontologist. 1980, 20: 649-655.PubMed

93.

Zarit SH, Todd PA, Zarit JM: Subjective burden of husbands and wives as caregivers: a longitudinal study. Gerontologist. 1986, 26: 260-266.PubMed

94.

Mari JJ, Williams P: A comparison of the validity of two psychiatric screening questionnaires (GHQ-12 and SRQ-20) in Brazil, using Relative Operating Characteristic (ROC) analysis. Psychol Med. 1985, 15: 651-659.PubMed

95.

Jha P, Gajalakshmi V, Gupta PC, Kumar R, Mony P, Dhingra N, Peto R: Prospective Study of One Million Deaths in India: Rationale, Design, and Validation Results. PLoS Med. 2005, 3: e18-10.1371/journal.pmed.0030018.PubMedPubMedCentral

96.

Gajalakshmi V, Peto R: Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India. BMC Public Health. 2004, 4: 47-10.1186/1471-2458-4-47.PubMedPubMedCentral

97.

Toole JF, Lefkowitz DS, Chambless LE, Wijnberg L, Paton CC, Heiss G: Self-reported transient ischemic attack and stroke symptoms: methods and baseline prevalence. The ARIC Study, 1987-1989. Am J Epidemiol. 1996, 144: 849-856.PubMed

98.

Fine JP, Gray RJ: A proportional hazards model for the subdistribution of a competing risk. Journal of the American Statistical Association. 1999, 94: 496-509. 10.2307/2670170.

99.

The ADMIXMAP program. 2007, [http://www.ucd.ie/genepi/software]

100.

Royston P, Babiker A: A menu driven facility for complex sample size calculation in randomized controlled trial with a survival or binary outcome. Stata Journal. 2002, 2: 151-163.

101.

Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychological Medicine 28(3):551-8,. 1998

102.

Smith SC, Lamping DL, Banerjee S, Harwood R, Foley B, Smith P, Cook JC, Murray J, Prince M, Levin E, Mann A, Knapp M: Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology. Health Technol Assess. 2005, 9 (10): 1-93.

103.

Medina-Lezama-J, J CP, J AC: Cardiovascular disease in Latin America. American Heart Journal. 2005, 149: e13-10.1016/j.ahj.2004.09.002.PubMed

104.

Prince M: Commentary: Two-phase surveys. A death is announced; no flowers please. Int J Epidemiol. 2003, 32: 1078-1080. 10.1093/ije/dyg321.PubMed

105.

M P: Dementia in Developing Countries (Guest Editorial). International Psychogeriatrics. 2001, 13: 389-393. 10.1017/S1041610201007797.

106.

Dunn G, Pickles A, Tansella M, Vazquez-Barquero JL: Two-phase epidemiological surveys in psychiatric research. British Journal of Psychiatry. 1999, 174: 95-100.PubMed

107.

Erkinjuntti T, Ostbye T, Steenhuis R, Hachinski V: The effect of different diagnostic criteria on the prevalence of dementia. N Engl J Med. 1997, 337: 1667-1674. 10.1056/NEJM199712043372306.PubMed

108.

group TD: The 10/66 Dementia Research Group - ADI intranet. 2007, [http://www.alz.co.uk/intranet/1066/]

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/7/165/prepub

Title: The protocols for the 10/66 dementia research group population-based research programme
Authors: Martin Prince
Cleusa P Ferri
Daisy Acosta
Emiliano Albanese
Raul Arizaga
Michael Dewey
Svetlana I Gavrilova
Mariella Guerra
Yueqin Huang
KS Jacob
ES Krishnamoorthy
Paul McKeigue
Juan Llibre Rodriguez
Aquiles Salas
Ana Luisa Sosa
Renata MM Sousa
Robert Stewart
Richard Uwakwe
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2007
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/1471-2458-7-165

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The protocols for the 10/66 dementia research group population-based research programme

Abstract

Background

Methods/design

Discussion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods/design

Discussion

Please log in to get access to this content

Other articles of this Issue 1/2007

Adolescent survey non-response and later risk of death. A prospective cohort study of 78 609 persons with 11-year follow-up

The benefits of participatory methodologies to develop effective community dialogue in the context of a microbicide trial feasibility study in Mwanza, Tanzania

The goitre rate, its association with reproductive failure, and the knowledge of iodine deficiency disorders (IDD) among women in Ethiopia: Cross-section community based study

Factors associated with a measles outbreak in children admitted at Mahosot Hospital, Vientiane, Laos

A randomized physiotherapy trial in patients with fecal incontinence: design of the PhysioFIT-study

Validity and reliability of the multidimensional health locus of control scale for college students