Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Psychiatry
Published in: BMC Psychiatry 1/2016

Open Access 01-12-2016 | Research article

The effect of the medicine administration route on health-related quality of life: Results from a time trade-off survey in patients with bipolar disorder or schizophrenia in 2 Nordic countries

Authors: Tine Rikke Jørgensen, Charlotte Emborg, Karianne Dahlen, Mette Bøgelund, Andreas Carlborg

Published in: BMC Psychiatry | Issue 1/2016

Login to get access

Abstract

Background

Agitation episodes are common among patients with schizophrenia or bipolar disorder. Oral and intramuscular administration methods are commonly used in pharmacological treatment of acute agitation. Recently, an innovative inhalation product with loxapine(Adasuve®)has become available for treatment of acute agitation episodes associated with bipolar disorder or schizophrenia. The objective for the present study was to investigate the impact of the pharmacological treatment’s administration methods on the health-related quality of life (HRQoL) in patients with bipolar disorder or schizophrenia in Denmark and Sweden using a time trade-off (TTO) approach.

Methods

The TTO methodology was used to examine the HRQoL impact of administration method of pharmacological treatment of acute agitation. Data were collected via an internet-based survey, using an existing panel of respondents with schizophrenia or bipolar disorder.

Results

Respondents considered living with schizophrenia/ bipolar disorder, having one yearly agitation episode treated with inhaler better than living with the same conditions and receiving treatment with tablet or injection. The utility value was 0.762 for inhalable treatment, 0.707 for injection and 0.734 for tablet treatment.

Conclusions

Patients’ preference for treatment delivery options showed that inhalation was associated with a significant utility gain when compared to injection or tablets. Inhalable loxapine may be a new tool for control of agitation episodes for strengthening the patient provider alliance when taking patient’s preference for delivery method into consideration.
Literature
1.
Alderfer BS, Allen MH. Treatment of agitation in bipolar disorder across the life cycle. J Clin Psychiatry. 2003;64 Suppl 4:3–9.PubMed
2.
3.
4.
Marder SR. A review of agitation in mental illness: treatment guidelines and current therapies. J Clin Psychiatry. 2006;67 Suppl 10:13–21.PubMed
5.
Zeller SL, Wilson MP. Acute treatment of agitation in schizophrenia. Drug Discov Today. 2011;8(1–2):25–9.
6.
Allen MH, Currier GW, Hughes DH, Reyes-Harde M, Docherty JP, Expert Consensus Panel for Behavioral Emergencies. The Expert Consensus Guideline Series. Treatment of behavioral emergencies. Postgrad.Med. 2001;(Spec No):1–88; quiz 89–90.
7.
Van Putten T, May PR, Marder SR, Wittmann LA. Subjective response to antipsychotic drugs. Arch Gen Psychiatry. 1981;38(2):187–90.CrossRefPubMed
8.
Kwentus J, Riesenberg RA, Marandi M, Manning RA, Allen MH, Fishman RS, et al. Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine. Bipolar Disord. 2012;14(1):31–40. doi:10.​1111/​j.​1399-5618.​2011.​00975.​x.CrossRefPubMed
9.
Allen MH, Feifel D, Lesem MD, Zimbroff DL, Ross R, Munzar P, et al. Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011;72(10):1313–21. doi:10.​4088/​JCP.​10m06011yel.CrossRefPubMed
10.
Lesem MD, Tran-Johnson TK, Riesenberg RA, Feifel D, Allen MH, Fishman R, et al. Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. Br J Psychiatry. 2011;198(1):51–8. doi:10.​1192/​bjp.​bp.​110.​081513.CrossRefPubMed
11.
12.
Rabinowitz JD, Wensley M, Lloyd P, Myers D, Shen W, Lu A, et al. Fast onset medications through thermally generated aerosols. J Pharmacol Exp Ther. 2004;309(2):769–75.CrossRefPubMed
13.
Rabinowitz JD, Lloyd PM, Munzar P, Myers DJ, Cross S, Damani R, et al. Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J Pharm Sci. 2006;95(11):2438–51.CrossRefPubMed
14.
15.
16.
Belgamwar RB, Fenton M. Olanzapine IM or velotab for acutely disturbed/agitated people with suspected serious mental illnesses. Cochrane Database Syst Rev. 2005;2, CD003729.PubMed
17.
Bellary S, Barnett AH. Inhaled insulin (Exubera): Combining efficacy and convenience. Diab Vasc Dis Res. 2006;3(3):179–85.CrossRefPubMed
18.
Fallowfield L, Atkins L, Catt S, Cox A, Coxon C, Langridge C, et al. Patients’ preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer. Ann Oncol. 2006;17(2):205–10.CrossRefPubMed
19.
Liu G, Franssen E, Fitch MI, Warner E. Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol. 1997;15(1):110–5.PubMed
20.
Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M, et al. Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes. 2004;2:12.CrossRefPubMedPubMedCentral
21.
22.
Dolan P, Jones-Lee M. The time trade-off: a note on the effect of lifetime reallocation of consumption and discounting. J Health Econ. 1997;16(6):731–9.CrossRefPubMed
23.
24.
Dolan P, Gudex C, Kind P, Williams A. The time trade-off method: results from a general population study. Health Econ. 1996;5(2):141–54.CrossRefPubMed
25.
Dolan P. The measurement of individual utility and social welfare. J Health Econ. 1998;17(1):39–52.CrossRefPubMed
26.
Robinson A, Dolan P, Williams A. Valuing health status using VAS and TTO: what lies behind the numbers? Soc Sci Med. 1997;45(8):1289–97.CrossRefPubMed
27.
Torrance GW, Feeny D. Utilities and quality-adjusted life years. Int J Technol Assess Health Care. 1989;5(4):559–75.CrossRefPubMed
28.
Torrance GW. Preferences for health outcomes and cost-utility analysis. Am J Manag Care. 1997;3(Suppl):S8–20.PubMed
29.
Dolan P. Aggregating health state valuations. J Health Serv Res Policy. 1997;2(3):160–5. discussion 166–7.PubMed
30.
31.
Battaglia J, Lindborg SR, Alaka K, Meehan K, Wright P. Calming versus sedative effects of intramuscular olanzapine in agitated patients. Am J Emerg Med. 2003;21(3):192–8.CrossRefPubMed
32.
Karagianis JL, Dawe IC, Thakur A, Bégin S, Raskin J, Roychowdhury SM. Rapid tranquilization with olanzapine in acute psychosis: a case series. J Clin Psychiatry. 2001;62 Suppl 2:12–6.PubMed
33.
Hsu WY, Huang SS, Lee BS, Chiu NY. Comparison of intramuscular olanzapine, orally disintegrating olanzapine tablets, oral risperidone solution, and intramuscular haloperidol in the management of acute agitation in an acute care psychiatric ward in Taiwan. J Clin Psychopharmacol. 2010;30(3):230–4. doi:10.​1097/​JCP.​0b013e3181db8715​.CrossRefPubMed
34.
Atkinson SE, Wilson PW. Comparing mean efficiency and productivity scores from small samples: a bootstrap methodology. J Product Anal. 1995;6(2):137–52.CrossRef
35.
36.
Briggs AH, Wonderling DE, Mooney CZ. Pulling cost-effectiveness up by its bootstraps: a non-parametric approach to confidence interval estimation. Health Econ. 1997;6(4):327–40.CrossRefPubMed
37.
38.
39.
40.
Ekman A, Dickman PW, Klint A, Weiderpass E, Litton JE. Feasibility of using web-based questionnaires in large population-based epidemiological studies. Eur J Epidemiol. 2006;21(2):103–11.CrossRefPubMed
41.
Lund E, Gram IT. Response rate according to title and length of questionnaire. Scand J Soc Med. 1998;26(2):154–60.PubMed
42.
Evans M, Holm Jensen H, Bøgelund M, Gundgaard J, Chubb B, Khunti K. Flexible insulin dosing improves health-related quality-of-life (HRQoL): a time trade-off survey. J Med Econ. 2013;16:1357–65.CrossRefPubMed
43.
Ridderstråle M, Evans LM, Jensen HH, Bøgelund M, Jensen MM, Ericsson Å, Jendle J. Estimating the impact of changes in HbA1c, body weight and insulin injection regimen on health related quality-of-life: a time trade off study. Health Qual Life Outcomes. 2016;14:13.CrossRefPubMedPubMedCentral
Metadata
Title
The effect of the medicine administration route on health-related quality of life: Results from a time trade-off survey in patients with bipolar disorder or schizophrenia in 2 Nordic countries
Authors
Tine Rikke Jørgensen
Charlotte Emborg
Karianne Dahlen
Mette Bøgelund
Andreas Carlborg
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-0930-6

Other articles of this Issue 1/2016

BMC Psychiatry 1/2016 Go to the issue

Research article

Is adjunctive pharmacotherapy in attention-deficit/hyperactivity disorder cost-effective in Canada: a cost-effectiveness assessment of guanfacine extended-release as an adjunctive therapy to a long-acting stimulant for the treatment of ADHD

Research article

Comparison of burden among family members of patients diagnosed with schizophrenia and bipolar disorder in a large acute psychiatric hospital in China

Research article

Psychosis associated with acute recreational drug toxicity: a European case series

Research article

Development and validation of clinical profiles of patients hospitalized due to behavioral and psychological symptoms of dementia

Research article

Depression, anxiety and suicidal ideation among 1st and 2nd generation migrants - results from the Gutenberg health study

Research article

Experiences of support in working toward personal recovery goals: a collaborative, qualitative study