Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Ophthalmology
Published in: BMC Ophthalmology 1/2024

Open Access 01-12-2024 | Stem Cell Transplantation | Case Report

Retinitis after haematopoietic stem cell transplantation with multiple intraocular viral infections (cytomegalovirus, Epstein‒Barr virus and herpes simplex virus)- a case report

Authors: Mengyun Liu, Hengqian He, Juntao Zhang, Shuanghua Xin, Qinkang Lu, Lifang Zhang, Weina Ren

Published in: BMC Ophthalmology | Issue 1/2024

Login to get access

Abstract

Background

To report a case of retinitis with multiple intraocular viral infections after second haematopoietic stem cell transplantation.

Case presentation

A 39-year-old female patient developed retinitis after a second haematopoietic stem cell transplant. Right eye was tested for three viral infections– cytomegalovirus, Epstein‒Barr virus and herpes simplex virus, while left was infected with cytomegalovirus. The patient was subsequently treated with vitreous cavity ganciclovir injections, and 1 week later both eyes tested negative for aqueous humour viruses.

Discussion and conclusion

CMV, EBV and HSV belong to the herpes virus family. They are all commonly observed in the body and represent opportunity infectious viruses. The retinitis they cause have different characteristics. But simultaneous infection of the eye by multiple viruses is quite rare. In this case, three viruses were detected in the patient’s eye, but whether the retina was caused by all three viruses at the same time could not be determined. A satisfactory outcome was achieved after treatment with vitreous cavity ganciclovir injection.
Appendix
Available only for authorised users
Literature
1.
Gao C, MA X, Zhang Z, et al. Asparaginase erwinia chrysanthemi for acute lymphoblastic leukemia and lymphoblastic lymphoma[J]. Drugs Today (Barc). 2022;58(6):261–71.CrossRefPubMed
2.
Cao XY, LI JJ, LU PH, et al. Efficacy and safety of cd19 car-t cell therapy for acute lymphoblastic leukemia patients relapsed after allogeneic hematopoietic stem cell transplantation[J]. Int J Hematol. 2022;116(3):315–29.CrossRefPubMed
3.
MA R, Liu XT, Chang YJ. Allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia: current status and future directions mainly focusing on a Chinese perspective[J]. Expert Rev Hematol. 2022;15(9):789–803.CrossRefPubMed
4.
Liu M, HE H, LU Q, et al. Cmv retinitis and subsequent acute cystoid macular oedema after treatment with vitreous ganciclovir injection: a case report[J]. BMC Ophthalmol. 2022;22(1):284.CrossRefPubMedPubMedCentral
5.
Huang EJ, Wang CP, Lai CH, et al. Rapid regression of cystoid macular edema associated with cytomegalovirus retinitis in adult acute myeloid leukemia by intravitreal methotrexate combined with oral valganciclovir: a case report with comparison of binocular outcome[J]. Taiwan J Ophthalmol. 2016;6(3):145–9.CrossRefPubMed
6.
Steve RJ, Mammen S, Selvaraj K, et al. Comparison of a chemiluminescence immunoassay and an enzyme immunoassay for detection of igm antibodies against measles, mumps, rubella, cytomegalovirus (cmv), Epstein Barr virus (ebv), and human herpes virus (hhv) -1 and– 2 infections[J]. Indian J Med Microbiol. 2022;40(3):354–8.CrossRefPubMed
7.
8.
YI ES, Lee JW, Kim YJ, et al. Risk factors and outcomes of cytomegalovirus infection in children post cord blood transplantation with focus on impact of graft-versus-host disease and immunosuppressants[J]. Ann Hematol. 2022;101(2):409–19.CrossRefPubMed
9.
Crippa F, Corey L, Chuang EL, et al. Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation[J]. Clin Infect Dis. 2001;32(2):214–9.CrossRefPubMed
10.
Reusser P, Fisher LD, Buckner CD, et al. Cytomegalovirus infection after autologous bone marrow transplantation: occurrence of cytomegalovirus disease and effect on engraftment[J]. Blood. 1990;75(9):1888–94.CrossRefPubMed
11.
James JA, KAufman KM, Farris AD, et al. An increased prevalence of epstein-barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus[J]. J Clin Invest. 1997;100(12):3019–26.CrossRefPubMedPubMedCentral
12.
13.
Classification criteria for. Acute retinal necrosis syndrome[J]. Am J Ophthalmol. 2021;228:237–44.CrossRef
14.
Madhavan HN, Priya K, Biswas J. Current perspectives of herpesviral retinitis and choroiditis[J]. Indian J Pathol Microbiol. 2004;47(4):453–68.PubMed
15.
Schoenberger SD, Kim SJ, Thorne JE, et al. Diagnosis and treatment of acute retinal necrosis: a report by the American academy of ophthalmology[J]. Ophthalmology. 2017;124(3):382–92.CrossRefPubMed
16.
Aksu-Ceylan N, Güner ME, Cebeci Z, et al. Association between prognosis of acute retinal necrosis and retinal involvement[J]. Turk J Ophthalmol. 2022;52(6):405–11.CrossRefPubMedPubMedCentral
17.
Cho J, Bhavsar AR, Cho DH, et al. Successful treatment of epstein-barr virus-induced necrotizing retinitis with intravitreous ganciclovir, foscarnet, and methotrexate[J]. Case Rep Ophthalmol. 2022;13(1):116–23.CrossRefPubMedPubMedCentral
18.
Mushiga Y, Komoto T, Nagai N, et al. Effects of intraocular treatments for epstein-barr virus (ebv) retinitis: a case report[J]. Med (Baltim). 2021;100(48):e28101.CrossRef
19.
Ergazaki M, Xinarianos G, Giannoudis A, et al. Detection of hsv, cmv and ebv by the polymerase chain-reaction technique in patients with inflammatory eye-diseases[J]. Oncol Rep. 1994;1(6):1207–10.PubMed
20.
Alvarez-Guzman C, Ortiz-Morales G, Ruiz-Lozano R et al. Simultaneous amplification of herpes simplex virus type 2 and epstein–barr virus in an immunocompetent host with acute retinal necrosis[J]. Pan-American J Ophthalmol. 2021;3(1).
21.
Lopez J, Hua HU, Toy BC. A case of herpes simplex virus and cytomegalovirus retinitis coinfection[J]. Retin Cases Brief Rep; 2023.
22.
Samanta R, Puthalath AS, Sood G et al. Macular dual retinitis with herpes simplex and cytomegalovirus following periocular corticosteroid in a patient of pemphigus vulgaris[J]. Eur J Ophthalmol. 2021:11206721211052847.
23.
Sato T, Kitamura R, Kaburaki T, et al. Retinitis associated with double infection of epstein-barr virus and varicella-zoster virus: a case report[J]. Med (Baltim). 2018;97(31):e11663.CrossRef
Metadata
Title
Retinitis after haematopoietic stem cell transplantation with multiple intraocular viral infections (cytomegalovirus, Epstein‒Barr virus and herpes simplex virus)- a case report
Authors
Mengyun Liu
Hengqian He
Juntao Zhang
Shuanghua Xin
Qinkang Lu
Lifang Zhang
Weina Ren
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2024
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-024-03300-4

Other articles of this Issue 1/2024

BMC Ophthalmology 1/2024 Go to the issue

Case Report

Closed head injury combined with orbital blowout fracture and displacement of the eyeball into the maxillary sinus in a 14-year-old boy: a case report

Research

The structure–function relationship between multifocal pupil perimetry and retinal nerve fibre layer in glaucoma

Case Report

Epithelial ingrowth in descemet membrane endothelial keratoplasty associated with vitreous loss

Research

Abnormalities of retinal function in type 2 diabetes mellitus patients without clinical diabetic retinopathy detected by multifocal electroretinogram

Study Protocol

Home vision therapy and prism prescription in presbyopic persons with convergence insufficiency: study protocol for a randomized controlled trial

Research

Classifications of anterior segment structure of congenital corneal opacity in infants and toddlers by ultrasound biomicroscopy and slit-lamp microscopic photographs: an observational study