Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Ophthalmology
Published in: BMC Ophthalmology 1/2018

Open Access 01-12-2018 | Research article

Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1

Authors: Jingli Guo, WenYi Tang, Xiaofeng Ye, Haixiang Wu, Gezhi Xu, Wei Liu, Yongjin Zhang

Published in: BMC Ophthalmology | Issue 1/2018

Login to get access

Abstract

Background

To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities.

Methods

A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed. Central macular thickness (CMT), the areas of macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, as measured by spectral domain OCT; and vascular density and the foveal avascular zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and correlated with VA.

Results

The mean baseline best-corrected VA of MT type 1 eyes was 0.45 ± 0.28. The mean CMT was 385.19 ± 75.21 μm in MT type 1 eyes and 252.43 ± 15.77 μm in contralateral eyes (Z = − 4.113, p < 0.001). The mean vessel density of the DCP was lower in MT type 1 eyes (47.25 ± 4.69%) than in contralateral eyes (53.93 ± 2.94%) and normal eyes (59.37 ± 2.50%) (Z = − 3.492, − 4.099; p < 0.001, < 0.001). The baseline logMAR VA was correlated with CMT (r = 0.682, p = 0.007), SCP density (r = − 0.652, p = 0.012), DCP density (r = − 0.700, p = 0.005), total area of EZ disruption (r = 0.649, p = 0.012); and total lengths of EZ (r = 0.681, p = 0.007), ELM (r = 0.699, p = 0.005) and DRIL (r = 0.707, p = 0.005) disruption in the 1-mm-diameter foveal region in MT type 1 eyes.

Conclusions

Decreased DCP density and the presence of DRIL may be predictive biomarkers of VA in MT type 1. CMT, SCP density, total area of EZ disruption, and lengths of EZ and ELM disruption within the 1-mm-diameter central region were strongly associated with VA.
Literature
1.
Gass JD, Oyakawa RT. Idiopathic juxtafoveolar retinal telangiectasis. Arch Ophthalmol. 1982;100:769–80.CrossRefPubMed
2.
Yannuzzi LA, Bardal AM, Freund KB, Chen KJ, Eandi CM, Blodi B. Idiopathic macular telangiectasia. Arch Ophthalmol. 2006;124:450–60.CrossRefPubMed
3.
Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, et al. Retinal structural alterations and macular sensitivity in idiopathic macular telangiectasia type 1. Retina. 2012;32:1973–80.CrossRefPubMed
4.
Matet A, Daruich A, Dirani A, Ambresin A, Behar-Cohen F. Macular telangiectasia type 1: capillary density and microvascular abnormalities assessed by optical coherence tomography angiography. Am J Ophthalmol. 2016;167:18–30.CrossRefPubMed
5.
Demirkaya N, van Dijk HW, van Schuppen SM, Abramoff MD, Garvin MK, Sonka M, et al. Effect of age on individual retinal layer thickness in normal eyes as measured with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2013;54(7):4934–40.CrossRefPubMed
6.
Abdolrahimzadeh S, Parisi F, Scavella V, Recupero SM. Optical coherence tomography evidence on the correlation of choroidal thickness and age with vascularized retinal layers in normal eyes. Retina. 2016;36(12):2329–38.CrossRefPubMed
7.
Wylegala A, Teper S, Dobrowolski D, Wylegala E. Optical coherence angiography: a review. Medicine (Baltimore). 2016;95(41):e4907.CrossRef
8.
Ishibazawa A, Nagaoka T, Yokota H, Takahashi A, Omae T, Song YS, et al. Characteristics of retinal neovascularization in proliferative diabetic retinopathy imaged by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016;57(14):6247–55.CrossRefPubMed
9.
Soares M, Neves C, Marques IP, Pires I, Schwartz C, Costa MA, et al. Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography. Br J Ophthalmol. 2017;101(1):62–8.CrossRefPubMed
10.
Kang JW, Yoo R, Jo YH, Kim HC. Correlation of microvascular structures on optical coherence tomography angiography with visual acuity in retinal vein occlusion. Retina. 2017;37(9):1700–9.CrossRefPubMed
11.
Balaratnasingam C, Inoue M, Ahn S, McCann J, Dhrami-Gavazi E, Yannuzzi LA, et al. Visual acuity is correlated with the area of the foveal avascular zone in diabetic retinopathy and retinal vein occlusion. Ophthalmology. 2016;123(11):2352–67.CrossRefPubMed
12.
Yannuzzi NA, Gregori NZ, Roisman L, Gupta N, Goldhagen BE, Goldhardt R. Fluorescein angiography versus optical coherence tomography angiography in macular telangiectasia type I treated with bevacizumab therapy. Ophthalmic Surg Lasers Imaging Retina. 2017;48(3):263–6.CrossRefPubMed
13.
Pappuru RR, Peguda HK, Dave VP. Optical coherence tomographic angiography in type 1 idiopathic macular telangiectasia. Clin Exp Optom. 2018;101(1):143–4.CrossRefPubMed
14.
Mao L, Weng SS, Gong YY, Yu SQ. Optical coherence tomography angiography of macular telangiectasia type 1: comparison with mild diabetic macular edema. Lasers Surg Med. 2017;49(3):225–32.CrossRefPubMed
15.
Chidambara L, Gadde SG, Yadav NK, Jayadev C, Bhanushali D, Appaji AM, et al. Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography. Br J Ophthalmol. 2016;100(11):1482–8.CrossRefPubMed
16.
Toto L, Di Antonio L, Mastropasqua R, Mattei PA, Carpineto P, Borrelli E, et al. Multimodal imaging of macular telangiectasia type 2: focus on vascular changes using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016;57(9):T268–76.CrossRef
17.
Drexler W, Sattmann H, Hermann B, Ko TH, Stur M, Unterhuber A, et al. Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography. Arch Ophthalmol. 2003;121(5):695–706.CrossRefPubMed
18.
Staurenghi G, Sadda S, Chakravarthy U, Spaide RF. Proposed lexicon for anatomic landmarks in normal posterior segment spectral domain optical coherence tomography. The IN•OCT consensus. Ophthalmology. 2014;121(8):1572–8.CrossRefPubMed
19.
Wakazono T, Ooto S, Hangai M, Yoshimura N. Photoreceptor outer segment abnormalities and retinal sensitivity in acute zonal occult outer retinopathy. Retina. 2013;33(3):642–8.CrossRefPubMed
20.
Grewal DS, O'Sullivan ML, Kron M, Jaffe GJ. Association of disorganization of retinal inner layers with visual acuity in eyes with uveitic cystoid macular edema. Am J Ophthalmol. 2017;177:116–25.CrossRefPubMed
21.
Sun JK, Lin MM, Lammer J, Prager S, Sarangi R, Silva PS, et al. Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema. JAMA Ophthalmol. 2014;132(11):1309–16.CrossRefPubMed
22.
Spaide RF. Volume-rendered optical coherence tomography of diabetic retinopathy pilot study. Am J Ophthalmol. 2015;160(6):1200–10.CrossRefPubMed
23.
Abreu-Gonzalez R, Diaz-Rodriguez R, Rubio-Rodriguez G, Gil-Hernandez MA, Abreu-Reyes P. Macular vascular flow area and vascular density in healthy population using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016;57(15):6713.CrossRefPubMed
24.
Birol G, Wang S, Budzynski E, Wangsa-Wirawan ND, Linsenmeier RA. Oxygen distribution and consumption in the macaque retina. Am J Physiol Heart Circ Physiol. 2007;293(3):H1696–704.CrossRefPubMed
25.
Sugiura Y, Okamoto F, Okamoto Y, Hiraoka T, Oshika T. Visual function in patients with idiopathic macular telangiectasia type 1. Acta Ophthalmol. 2016;94(7):e672–3.CrossRefPubMed
Metadata
Title
Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1
Authors
Jingli Guo
WenYi Tang
Xiaofeng Ye
Haixiang Wu
Gezhi Xu
Wei Liu
Yongjin Zhang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-018-0737-y

Other articles of this Issue 1/2018

BMC Ophthalmology 1/2018 Go to the issue

Research article

Comparison of a new swept-source optical biometer with a partial coherence interferometry

Case report

Exophthalmos in a young woman with no Graves’ disease – a case report of IgG4-related orbitopathy

Research article

Correlation of subfoveal choroidal thickness with axial length, refractive error, and age in adult highly myopic eyes

Case report

Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis

Research article

Evaluation of day care versus inpatient cataract surgery performed at a Jiangsu public Tertiary A hospital

Research article

Retinal-image quality and contrast sensitivity function in eyes with epiretinal membrane: a cross-sectional observational clinical study