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Open Access 01-12-2019 | Acute Lymphoblastic Leukemia | Research article

Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

Authors: Juan Carlos Núñez-Enríquez, Ana Elena Gil-Hernández, Elva Jiménez-Hernández, Arturo Fajardo-Gutiérrez, Aurora Medina-Sansón, Janet Flores-Lujano, Laura Eugenia Espinoza-Hernández, David Aldebarán Duarte-Rodríguez, Raquel Amador-Sánchez, José Gabriel Peñaloza-González, José Refugio Torres-Nava, Rosa Martha Espinosa-Elizondo, Luz Victoria Flores-Villegas, Laura Elizabeth Merino-Pasaye, María Luisa Pérez-Saldivar, Elisa María Dorantes-Acosta, Beatriz Cortés-Herrera, Karina Anastacia Solis-Labastida, Nora Nancy Núñez-Villegas, Martha Margarita Velázquez-Aviña, Angélica Rangel-López, Ana Itamar González-Ávila, Jessica Denisse Santillán-Juárez, Alejandra Jimena García-Velázquez, Silvia Jiménez-Morales, Vilma Carolina Bekker-Méndez, Haydee Rosas-Vargas, Minerva Mata-Rocha, Omar Alejandro Sepúlveda-Robles, Jorge Alfonso Martín-Trejo, Juan Manuel Mejía-Aranguré

Published in: BMC Cancer | Issue 1/2019

Abstract

Background

Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood overweight and obesity are reaching epidemic proportions. They have been associated with poor outcomes in children with ALL. The aim of present study was to identify if overweight and obesity are predictors of early mortality and relapse in Mexican children with ALL.

Methods

A multicenter cohort study was conducted. ALL children younger than 15 years old were included and followed-up during the first 24 months after diagnosis. Overweight and obesity were classified according World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) criteria. Early mortality and early relapses were the main outcomes.

Results

A total of 1070 children were analyzed. Overweight/obesity at diagnosis were predictors of early mortality (WHO: HR = 1.4, 95%CI:1.0–2.0; CDC: HR = 1.6, 95%CI:1.1–2.3). However, no associations between overweight (WHO: HR = 1.5, 95%CI:0.9–2.5; CDC: HR = 1.0; 95% CI:0.6–1.6) and obesity (WHO: HR = 1.5, 95%CI:0.7–3.2; CDC: HR = 1.4; 95%CI:0.9–2.3) with early relapse were observed.

Conclusions

Overweight and obese patients embody a subgroup with high risk of dying during leukemia treatment.

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Title: Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study
Authors: Juan Carlos Núñez-Enríquez
Ana Elena Gil-Hernández
Elva Jiménez-Hernández
Arturo Fajardo-Gutiérrez
Aurora Medina-Sansón
Janet Flores-Lujano
Laura Eugenia Espinoza-Hernández
David Aldebarán Duarte-Rodríguez
Raquel Amador-Sánchez
José Gabriel Peñaloza-González
José Refugio Torres-Nava
Rosa Martha Espinosa-Elizondo
Luz Victoria Flores-Villegas
Laura Elizabeth Merino-Pasaye
María Luisa Pérez-Saldivar
Elisa María Dorantes-Acosta
Beatriz Cortés-Herrera
Karina Anastacia Solis-Labastida
Nora Nancy Núñez-Villegas
Martha Margarita Velázquez-Aviña
Angélica Rangel-López
Ana Itamar González-Ávila
Jessica Denisse Santillán-Juárez
Alejandra Jimena García-Velázquez
Silvia Jiménez-Morales
Vilma Carolina Bekker-Méndez
Haydee Rosas-Vargas
Minerva Mata-Rocha
Omar Alejandro Sepúlveda-Robles
Jorge Alfonso Martín-Trejo
Juan Manuel Mejía-Aranguré
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Acute Lymphoblastic Leukemia
Obesity
Obesity
Overweight
Leukemia
Published in: BMC Cancer / Issue 1/2019
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-019-5878-8

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