Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Authors: Wei-Dong Leng, Xiu-Jie Wen, Joey S. W. Kwong, Wei Huang, Jian-Gang Chen, Xian-Tao Zeng

Published in: BMC Cancer | Issue 1/2016

Login to get access

Abstract

Background

Numerous case–control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (−765G > C), rs689466 (−1195G > A), and rs5275 (8473 T > C)) and the risk of head and neck squamous cell carcinoma (HNSCC). However, the results were inconsistent. Therefore, we conducted this meta-analysis to investigate the association.

Methods

We searched in PubMed, Embase, and Web of Science up to January 20, 2015 (last updated on May 12, 2016). Two independent reviewers extracted the data. Odds ratios (ORs) with their 95 % confidence intervals (CIs) were used to assess the association. All statistical analyses were performed using the Review Manager (RevMan) 5.2 software.

Results

Finally 8 case–control studies were included in this meta-analysis. For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. The pooled results from adjusted data all revealed non-significant association between these three polymorphisms and risk of HNSCC. We also found a similar result in the subgroup analyses, based on both unadjusted data and adjusted data.

Conclusion

Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC. Further large and well-designed studies are necessary to validate this association.
Literature
1.
Zeng XT, Luo W, Huang W, Wang Q, Guo Y, Leng WD. Tooth loss and head and neck cancer: a meta-analysis of observational studies. PLoS ONE. 2013;8(11), e79074.CrossRefPubMedPubMedCentral
2.
Li Y, Mao Y, Zhang Y, Cai S, Chen G, Ding Y, Guo J, Chen K, Jin M. Alcohol drinking and upper aerodigestive tract cancer mortality: a systematic review and meta-analysis. Oral Oncol. 2014;50(4):269–75.CrossRefPubMed
3.
Zeng XT, Deng AP, Li C, Xia LY, Niu YM, Leng WD. Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS ONE. 2013;8(10), e79017.CrossRefPubMedPubMedCentral
4.
Wyss A, Hashibe M, Chuang SC, Lee YC, Zhang ZF, Yu GP, Winn DM, Wei Q, Talamini R, Szeszenia-Dabrowska N, et al. Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Am J Epidemiol. 2013;178(5):679–90.CrossRefPubMedPubMedCentral
5.
Zeng XT, Leng WD, Zhang C, Liu J, Cao SY, Huang W. Meta-analysis on the association between toothbrushing and head and neck cancer. Oral Oncol. 2015;51(5):446–51.CrossRefPubMed
6.
Abogunrin S, Di Tanna GL, Keeping S, Carroll S, Iheanacho I. Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis. BMC Cancer. 2014;14(1):968.CrossRefPubMedPubMedCentral
7.
Zeng XT, Luo W, Geng PL, Guo Y, Niu YM, Leng WD. Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis. BMC Cancer. 2014;14:469.CrossRefPubMedPubMedCentral
8.
Brunotto M, Zarate AM, Bono A, Barra JL, Berra S. Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5 years. Oral Oncol. 2014;50(3):178–88.CrossRefPubMed
9.
Wang Y, Gao X, Wei F, Zhang X, Yu J, Zhao H, Sun Q, Yan F, Yan C, Li H, et al. The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case–control studies. Tumour Biol. 2015;36(2):1029-1038.
10.
Wu W, Liu L, Yin Z, Guan P, Li X, Zhou B. Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. PLoS ONE. 2014;9(1), e86798.CrossRefPubMedPubMedCentral
11.
Zhang E, Cui Z, Xu Z, Duan W, Huang S, Tan X, Yin Z, Sun C, Lu L. Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis. BMC Cancer. 2013;13:594.CrossRefPubMedPubMedCentral
12.
Hu YY, Yuan H, Jiang GB, Chen N, Wen L, Leng WD, Zeng XT, Niu YM. Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects. PLoS ONE. 2012;7(4), e35220.CrossRefPubMedPubMedCentral
13.
Leng WD, He MN, Chen QL, Gong H, Zhang L, Zeng XT. Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer: a meta-analysis involving 2,444 individuals. Mol Biol Rep. 2013;40(10):5987–92.CrossRefPubMed
14.
Jiang L, Weng H, Chen MY, Zhang C, Zeng XT. Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals. Mol Biol Rep. 2014;41(7):4795–801.CrossRefPubMed
15.
Fritsche E, Baek SJ, King LM, Zeldin DC, Eling TE, Bell DA. Functional characterization of cyclooxygenase-2 polymorphisms. J Pharmacol Exp Ther. 2001;299(2):468–76.PubMed
16.
Wu H, Wu X, Wan G, Zhang S. Associations between Cox-2 rs20417 and rs5275 polymorphisms and the risk of hepatocellular carcinoma: a meta analysis. Int J Clin Exp Pathol. 2014;7(10):6898–905.PubMedPubMedCentral
17.
Peng Q, Yang S, Lao X, Tang W, Chen Z, Lai H, Wang J, Sui J, Qin X, Li S. Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case–control studies. PLoS ONE. 2014;9(4), e94790.CrossRefPubMedPubMedCentral
18.
Dai ZJ, Shao YP, Ma XB, Xu D, Tang W, Kang HF, Lin S, Wang M, Ren HT, Wang XJ. Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer: an updated meta-analysis involving 34,590 subjects. Dis Markers. 2014;2014:484729.CrossRefPubMedPubMedCentral
19.
Yang X, Li B, Si T, Liu Y, Guo Z. Association between the 8473 T > C polymorphism of PTGS2 and prostate cancer risk: a metaanalysis including 24,716 subjects. Onkologie. 2013;36(4):182–6.CrossRefPubMed
20.
Yan WF, Sun PC, Nie CF, Wu G. Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case–control studies. Tumour Biol. 2013;34(6):3323–30.CrossRefPubMed
21.
Yang CY, Meng CL, Liao CL, Wong PY. Regulation of cell growth by selective COX-2 inhibitors in oral carcinoma cell lines. Prostaglandins Other Lipid Mediat. 2003;72(3–4):115–30.CrossRefPubMed
22.
Saba NF, Choi M, Muller S, Shin HJ, Tighiouart M, Papadimitrakopoulou VA, El-Naggar AK, Khuri FR, Chen ZG, Shin DM. Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 2009;2(9):823–9.CrossRef
23.
Zeng X, Zhang Y, Kwong JS, Zhang C, Li S, Sun F, Niu Y, Du L. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10.CrossRefPubMed
24.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.CrossRefPubMedPubMedCentral
25.
Salanti G, Amountza G, Ntzani EE, Ioannidis JP. Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet. 2005;13(7):840–8.CrossRefPubMed
26.
Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 2006;11(2):193–206.CrossRefPubMed
27.
Campa D, Hashibe M, Zaridze D, Szeszenia-Dabrowska N, Mates IN, Janout V, Holcatova I, Fabianova E, Gaborieau V, Hung RJ, et al. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. Cancer Causes Control. 2007;18(4):449–55.CrossRefPubMed
28.
Chiang SL, Chen PH, Lee CH, Ko AM, Lee KW, Lin YC, Ho PS, Tu HP, Wu DC, Shieh TY, et al. Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G > a polymorphism reveal risk of oral cancer. Cancer Res. 2008;68(20):8489–98.CrossRefPubMed
29.
Lin YC, Huang HI, Wang LH, Tsai CC, Lung O, Dai CY, Yu ML, Ho CK, Chen CH. Polymorphisms of COX-2 -765G > C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. Oral Oncol. 2008;44(8):798–804.CrossRefPubMed
30.
Peters WH, Lacko M, Te Morsche RH, Voogd AC, Oude Ophuis MB, Manni JJ. COX-2 polymorphisms and the risk for head and neck cancer in white patients. Head Neck. 2009;31(7):938–43.CrossRefPubMed
31.
Mittal M, Kapoor V, Mohanti BK, Das SN. Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians. Oral Oncol. 2010;46(8):622–6.CrossRefPubMed
32.
Lakshmi A, Muralidhar S, Kalyan Kumar C, Pavan Kumar A, Kalyana Chakravarthy P, Anjaneyulu V, Kaiser J. Cyclooxygenase-2-765G > C functional promoter polymorphism and its association with oral squamous cell carcinoma. J Investig Clin Dent. 2012;3(3):182–8.CrossRefPubMed
33.
Chang JS, Lo HI, Wong TY, Huang CC, Lee WT, Tsai ST, Chen KC, Yen CJ, Wu YH, Hsueh WT, et al. Investigating the association between oral hygiene and head and neck cancer. Oral Oncol. 2013;49(10):1010–7.CrossRefPubMed
34.
Niu Y, Yuan H, Shen M, Li H, Hu Y, Chen N. Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. J Craniofac Surg. 2014;25(2):333–7.CrossRefPubMed
35.
Zeng XT, Liu DY, Kwong JS, Leng WD, Xia LY, Mao M. Meta-Analysis of Association Between Interleukin-1beta C-511 T Polymorphism and Chronic Periodontitis Susceptibility. J Periodontol. 2015;86(6):812–9.CrossRefPubMed
36.
Mandal RK, Yadav SS, Panda AK, Khattri S. Vascular Endothelial Growth Factor 936 C > T Polymorphism Increased Oral Cancer Risk: Evidence from a Meta-Analysis. Genet Test Mol Biomarkers. 2013.
37.
Xia LY, Zeng XT, Li C, Leng WD, Fan MW. Association between p53 Arg72Pro polymorphism and the risk of human papillomavirus-related head and neck squamous cell carcinoma: a meta-analysis. Asian Pac J Cancer Prev. 2013;14(10):6127–30.CrossRefPubMed
38.
Yan Y, Weng H, Shen ZH, Wu L, Zeng XT. Association between interleukin–4 gene–590 c/t,–33 c/t, and 70–base-pair polymorphisms and periodontitis susceptibility: a meta-analysis. J Periodontol. 2014;85(11):e354–62.CrossRefPubMed
39.
Zhao F, Cao Y, Zhu H, Huang M, Yi C, Huang Y. The–765G > C Polymorphism in the Cyclooxygenase–2 Gene and Digestive System Cancer: a Meta-analysis. Asian Pac J Cancer Prev. 2014;15(19):8301–10.CrossRefPubMed
Metadata
Title
COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data
Authors
Wei-Dong Leng
Xiu-Jie Wen
Joey S. W. Kwong
Wei Huang
Jian-Gang Chen
Xian-Tao Zeng
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2535-3

Other articles of this Issue 1/2016

BMC Cancer 1/2016 Go to the issue

Research article

The lack of clinical value of peritoneal washing cytology in high risk patients undergoing risk-reducing salpingo-oophorectomy: a retrospective study and review

Research article

Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study

Research article

Clinical outcomes and prognostic factors of cyberknife stereotactic body radiation therapy for unresectable hepatocellular carcinoma

Research article

Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy

Research article

Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression

Case report

A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits