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Published in: BMC Pregnancy and Childbirth 1/2019

Open Access 01-12-2019 | Anemia | Research article

Risk factors and consequences of undiagnosed cesarean scar pregnancy: a cohort study in China

Authors: Ri-hua Xie, Xiaoyan Guo, Meng Li, Yan Liao, Laura Gaudet, Mark Walker, Huizhong Lei, Shi Wu Wen

Published in: BMC Pregnancy and Childbirth | Issue 1/2019

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Abstract

Background

The historically high cesarean section rate and the recent change in second-child policy could increase the risk of cesarean scar pregnancy (CSP) in China. This study aims to assess risk factors and consequences of undiagnosed CSP in China.

Methods

We conducted a retrospective cohort study between January 2013 and December 2017 in Qingyuan, Guangdong, China. Independent risk factors for undiagnosed CSP at the first contact with healthcare providers were assessed by log binomial regression analysis. Occurrence of serious complications was compared between undiagnosed and diagnosed CSP cases.

Results

A total of 195 women with CSP were included in the analysis. Of them, 81 (41.5%) women were undiagnosed at the first contact with healthcare providers. Women initially cared in primary or secondary hospitals were at increased risk for undiagnosed CSP: adjusted relative risks (95% confidence intervals) were 3.28 (2.06, 5.22) and 1.91 (1.16, 3.13), respectively, compared with women initially cared in the tertiary hospital. Undiagnosed CSP cases had higher incidences in serious complications (11 versus 0) and post-surgery anemia (23 (28.4%) versus 8 (7.0%)), stayed longer in hospital, and cost higher than diagnosed CSP cases.

Conclusions

Initial care provided at primary or secondary maternity care facilities is an important risk factor for undiagnosed CSP, with serious consequences to the affected women.
Literature
1.
go back to reference Timor-Tritsch IE, Monteagudo A, Santos R, Tsymbal T, Pineda G, Arslan AA. The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol. 2012;207:44.e1–13.CrossRef Timor-Tritsch IE, Monteagudo A, Santos R, Tsymbal T, Pineda G, Arslan AA. The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol. 2012;207:44.e1–13.CrossRef
2.
go back to reference Timor-Tritsch IE, Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accrete and cesarean scar pregnancy. A review. Am J Obstet Gynecol. 2012;207:44.e14–29.CrossRef Timor-Tritsch IE, Monteagudo A. Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accrete and cesarean scar pregnancy. A review. Am J Obstet Gynecol. 2012;207:44.e14–29.CrossRef
3.
go back to reference Timor-Tritsch IE, Monteagudo A, Cali G, Refaey HE, Agten AK, Arslan AA. Easy sonographic differential diagnosis between intrauterine pregnancy and cesarean delivery scar pregnancy in the early first trimester. Am J Obstet Gynecol. 2016;215:225.e1–7.CrossRef Timor-Tritsch IE, Monteagudo A, Cali G, Refaey HE, Agten AK, Arslan AA. Easy sonographic differential diagnosis between intrauterine pregnancy and cesarean delivery scar pregnancy in the early first trimester. Am J Obstet Gynecol. 2016;215:225.e1–7.CrossRef
4.
go back to reference Riaz RM, Williams TR, Craig BM, Myers DT. Cesarean scar ectopic pregnancy: imaging features, current treatment oplions, and clinical autcomes. Abdom Imaging. 2015;40:2589–99.CrossRef Riaz RM, Williams TR, Craig BM, Myers DT. Cesarean scar ectopic pregnancy: imaging features, current treatment oplions, and clinical autcomes. Abdom Imaging. 2015;40:2589–99.CrossRef
5.
go back to reference Maymon R, Halperin R, Mendlovic S, Schneider D, Herman A. Ectopic pregnancies in a caesarean scar: review of the medical approach to an iatrogenic complication. Hum Reprod Update. 2004;10:512–23.CrossRef Maymon R, Halperin R, Mendlovic S, Schneider D, Herman A. Ectopic pregnancies in a caesarean scar: review of the medical approach to an iatrogenic complication. Hum Reprod Update. 2004;10:512–23.CrossRef
7.
go back to reference Liang J, Mu Y, Li X, Tang W, Wang Y, Liu Z, et al. Relaxation of the one child policy and trends in caesarean section rates and birth outcomes in China between 2012 and 2016: observational study of nearly seven million health facility births. BMJ. 2018;360:k817.CrossRef Liang J, Mu Y, Li X, Tang W, Wang Y, Liu Z, et al. Relaxation of the one child policy and trends in caesarean section rates and birth outcomes in China between 2012 and 2016: observational study of nearly seven million health facility births. BMJ. 2018;360:k817.CrossRef
8.
go back to reference Ghezzi F, Laganà D, Franchi M, Fugazzola C, Bolis P. Conservative treatment by chemotherapy and uterine arteries embolization of a cesarean scar pregnancy. Eur J Obstet Gynecol Reprod Biol. 2002;103:88–91.CrossRef Ghezzi F, Laganà D, Franchi M, Fugazzola C, Bolis P. Conservative treatment by chemotherapy and uterine arteries embolization of a cesarean scar pregnancy. Eur J Obstet Gynecol Reprod Biol. 2002;103:88–91.CrossRef
9.
go back to reference Fylstra DL, Pound-Chang T, Miller MG, Cooper A, Miller KM. Ectopic pregnancy within a cesarean delivery scar: a case report. Am J Obstet Gynecol. 2002;187:302–4.CrossRef Fylstra DL, Pound-Chang T, Miller MG, Cooper A, Miller KM. Ectopic pregnancy within a cesarean delivery scar: a case report. Am J Obstet Gynecol. 2002;187:302–4.CrossRef
10.
go back to reference Lam PM, Lo KW. Multiple-dose methotrexate for pregnancy in a cesarean section scar. A case report. J Reprod Med. 2002;47:332–4.PubMed Lam PM, Lo KW. Multiple-dose methotrexate for pregnancy in a cesarean section scar. A case report. J Reprod Med. 2002;47:332–4.PubMed
11.
go back to reference Haimov-Kochman R, Sciaky-Tamir Y, Yanai N, Yagel S. Conservative management of two ectopic pregnancies implanted in previous uterine scars. Ultrasound Obstet Gynecol. 2002;19:616–9.CrossRef Haimov-Kochman R, Sciaky-Tamir Y, Yanai N, Yagel S. Conservative management of two ectopic pregnancies implanted in previous uterine scars. Ultrasound Obstet Gynecol. 2002;19:616–9.CrossRef
12.
go back to reference Hartung J, Meckies J. Management of a case of uterine scar pregnancy by transabdominal potassium chloride injection. Ultrasound Obstet Gynecol. 2003;21:94–5.CrossRef Hartung J, Meckies J. Management of a case of uterine scar pregnancy by transabdominal potassium chloride injection. Ultrasound Obstet Gynecol. 2003;21:94–5.CrossRef
13.
go back to reference Chuang J, Seow KM, Cheng WC, Tsai YL, Hwang JL. Conservative treatment of ectopic pregnancy in a caesarean section scar. Br J Obstet Gynecol. 2003;110:869–70.CrossRef Chuang J, Seow KM, Cheng WC, Tsai YL, Hwang JL. Conservative treatment of ectopic pregnancy in a caesarean section scar. Br J Obstet Gynecol. 2003;110:869–70.CrossRef
14.
go back to reference Yang MJ, Jeng MH. Combination of transarterial embolization of uterine arteries and conservative surgical treatment for pregnancy in a cesarean section scar. J Reprod Med. 2003;48:213–6.PubMed Yang MJ, Jeng MH. Combination of transarterial embolization of uterine arteries and conservative surgical treatment for pregnancy in a cesarean section scar. J Reprod Med. 2003;48:213–6.PubMed
15.
go back to reference Weimin W, Wenqing L. Effect of early pregnancy on a previous lower segment cesarean section scar. Int J Gynaecol Obstet. 2002;77:201–7.CrossRef Weimin W, Wenqing L. Effect of early pregnancy on a previous lower segment cesarean section scar. Int J Gynaecol Obstet. 2002;77:201–7.CrossRef
16.
go back to reference Jurkovic D, Hillaby K, Woelfer B, Lawrence A, Salim R, Elson CJ. First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment cesarean section scar. Ultrasound Obstet Gynecol. 2003;21:220–7.CrossRef Jurkovic D, Hillaby K, Woelfer B, Lawrence A, Salim R, Elson CJ. First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment cesarean section scar. Ultrasound Obstet Gynecol. 2003;21:220–7.CrossRef
17.
go back to reference Maymon R, Halperin R, Mendlovic S, Schneider D, Vaknin Z, Herman A, et al. Ectopic pregnancies in cesarean section scars: the 8-year experience of one medical center. Hum Reprod. 2004;19:278–84.CrossRef Maymon R, Halperin R, Mendlovic S, Schneider D, Vaknin Z, Herman A, et al. Ectopic pregnancies in cesarean section scars: the 8-year experience of one medical center. Hum Reprod. 2004;19:278–84.CrossRef
18.
go back to reference Seow KM, Huang LW, Lin YH, Lin MY, Tsai YL, Hwang JL. Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol. 2004;23:247–53.CrossRef Seow KM, Huang LW, Lin YH, Lin MY, Tsai YL, Hwang JL. Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol. 2004;23:247–53.CrossRef
19.
go back to reference Shih JC. Cesarean scar pregnancy: diagnosis with three-dimensional (3D) ultrasound and 3D power Doppler ultrasound. Obstet Gynecol. 2004;23:306–7. Shih JC. Cesarean scar pregnancy: diagnosis with three-dimensional (3D) ultrasound and 3D power Doppler ultrasound. Obstet Gynecol. 2004;23:306–7.
20.
go back to reference Marchiolé P, Gorlero F, de Caro G, Podestà M, Valenzano M. Intramural pregnancy embedded in a previous cesarean section scar treated conservatively. Ultrasound Obstet Gynecol. 2004;23:307–9.CrossRef Marchiolé P, Gorlero F, de Caro G, Podestà M, Valenzano M. Intramural pregnancy embedded in a previous cesarean section scar treated conservatively. Ultrasound Obstet Gynecol. 2004;23:307–9.CrossRef
21.
go back to reference Einenkel J, Stumpp P, Kösling S, Horn LC, Höckel M. A misdiagnosed case of caesarean scar pregnancy. Arch Gynecol Obstet. 2005;271:178–81.CrossRef Einenkel J, Stumpp P, Kösling S, Horn LC, Höckel M. A misdiagnosed case of caesarean scar pregnancy. Arch Gynecol Obstet. 2005;271:178–81.CrossRef
22.
go back to reference Qingyuan Bureau of Statistics. Qingyuan 2017 Statistics. Guangdong:Qingyuan, 2017. Qingyuan Bureau of Statistics. Qingyuan 2017 Statistics. Guangdong:Qingyuan, 2017.
23.
go back to reference Wong WCW, Zhu S, Ong JJ, Peng M, Lam CLK, Kidd MR, Roland M, Jiang S. Primary care workforce and continuous medical education in China: lessons to learn from a nationwide cross-sectional survey. BMJ Open. 2017;7:e015145.CrossRef Wong WCW, Zhu S, Ong JJ, Peng M, Lam CLK, Kidd MR, Roland M, Jiang S. Primary care workforce and continuous medical education in China: lessons to learn from a nationwide cross-sectional survey. BMJ Open. 2017;7:e015145.CrossRef
24.
go back to reference Wang X, Jiang R, Li J, Chen J, Burström B, Burström K. What do patients care most about in China's public hospitals? Interviews with patients in Jiangsu Province. BMC Health Serv Res. 2018;18:97.CrossRef Wang X, Jiang R, Li J, Chen J, Burström B, Burström K. What do patients care most about in China's public hospitals? Interviews with patients in Jiangsu Province. BMC Health Serv Res. 2018;18:97.CrossRef
25.
go back to reference Zhang A, Xu Y. Discussion of the misdiagnosed reasons of uterine scar pregnancy after cesarean section. Modern Med J. 2012;8:447–8. Zhang A, Xu Y. Discussion of the misdiagnosed reasons of uterine scar pregnancy after cesarean section. Modern Med J. 2012;8:447–8.
26.
go back to reference Oshorn D, Williams TR, Graing BM. Cesarean scar pregnancy: sonographic andmagnetic resonance imaging finds, complications, and treatment. J Ultrasound Med. 2012;3:1449–56.CrossRef Oshorn D, Williams TR, Graing BM. Cesarean scar pregnancy: sonographic andmagnetic resonance imaging finds, complications, and treatment. J Ultrasound Med. 2012;3:1449–56.CrossRef
27.
go back to reference Armstrong V, Hansen WF, Van Voorhis BJ, Syrop CH. Detection of cesarean scars by transvaginal ultrasound. Obstet Gynecol. 2003;101:61–5.PubMed Armstrong V, Hansen WF, Van Voorhis BJ, Syrop CH. Detection of cesarean scars by transvaginal ultrasound. Obstet Gynecol. 2003;101:61–5.PubMed
28.
go back to reference Cheng PJ, Chueh HY, Soong YK. Sonographic diagnosis of a uterine defect in a pregnancy at 6 weeks’ gestation with a history of curettage. Ultrasound Obstet Gynecol. 2003;21:501–3.CrossRef Cheng PJ, Chueh HY, Soong YK. Sonographic diagnosis of a uterine defect in a pregnancy at 6 weeks’ gestation with a history of curettage. Ultrasound Obstet Gynecol. 2003;21:501–3.CrossRef
29.
go back to reference Lin M, Xie H, Zh Y. Application of ultrasound in surveillance of cearean section scar pregnancy and cervical pregnancy. Chin Med Imaging. 2006;175:266–8. Lin M, Xie H, Zh Y. Application of ultrasound in surveillance of cearean section scar pregnancy and cervical pregnancy. Chin Med Imaging. 2006;175:266–8.
30.
go back to reference Pędraszewski P, Wlaźlak E, Panek W, Surkont G. Cesarean scar pregnancy - a new challenge for obstetricians. J Ultrason. 2018;18:56–62.CrossRef Pędraszewski P, Wlaźlak E, Panek W, Surkont G. Cesarean scar pregnancy - a new challenge for obstetricians. J Ultrason. 2018;18:56–62.CrossRef
Metadata
Title
Risk factors and consequences of undiagnosed cesarean scar pregnancy: a cohort study in China
Authors
Ri-hua Xie
Xiaoyan Guo
Meng Li
Yan Liao
Laura Gaudet
Mark Walker
Huizhong Lei
Shi Wu Wen
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2019
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-019-2523-0

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