Skip to main content
Top
Published in: Abdominal Radiology 7/2015

01-10-2015 | Pictorial Essay

Cesarean scar ectopic pregnancy: imaging features, current treatment options, and clinical outcomes

Authors: Rehan M. Riaz, Todd R. Williams, Brian M. Craig, Daniel T. Myers

Published in: Abdominal Radiology | Issue 7/2015

Login to get access

Abstract

Purpose

Cesarean scar ectopic pregnancy (CSEP) is considered to be quite rare, but the frequency is increasing given the increasing number of cesarean sections being performed, along with increased detection due to widespread use of early endovaginal sonography. The normal sonographic and magnetic resonance findings of this phenomenon will be discussed, including the appearance of complications associated with abnormal placentation, such as the placenta accreta spectrum. Cases of CSEP at our institution will be illustrated, along with clinical presentations and treatment outcomes.

Methods

The study included women who were diagnosed with a CSEP in the first trimester, which was confirmed by ultrasound. The clinical presentations, imaging findings, and treatment outcomes of these pregnancies were recorded.

Results

In our series, treatment ranged from no intervention with fetal demise on short-term follow-up ultrasound to viable near-term deliveries requiring cesarean section, urgent blood products, and emergent surgery. The majority of our cases 75 % (15 of 20) underwent successful early first trimester termination by a combination of systemic methotrexate administration, ultrasound-guided injection of embryocidal agents, and/or surgery.

Conclusion

Early imaging recognition and diagnosis of CSEP is critically important to minimize maternal complications, maintain treatment options, and potentially preserve future fertility.
Literature
1.
go back to reference Jurkovic D, Hillaby K, Woelfer B, et al. (2003) First-trimester diagnosis and management of pregnancies implanted into the lower uterine caesarean section scar. Ultrasound Obstet Gynecol 21:220–227CrossRefPubMed Jurkovic D, Hillaby K, Woelfer B, et al. (2003) First-trimester diagnosis and management of pregnancies implanted into the lower uterine caesarean section scar. Ultrasound Obstet Gynecol 21:220–227CrossRefPubMed
2.
go back to reference Timor-Tritsch IE, Monteagudo A, Santos R, et al. (2012) The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol 207:44.e1–44.e13CrossRef Timor-Tritsch IE, Monteagudo A, Santos R, et al. (2012) The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol 207:44.e1–44.e13CrossRef
3.
go back to reference Rotas MA, Haberman S, Levgur M (2006) Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol 107:1373–1381CrossRefPubMed Rotas MA, Haberman S, Levgur M (2006) Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol 107:1373–1381CrossRefPubMed
4.
go back to reference Seow KM, Huang LW, Lin YH, et al. (2004) Caesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol 23:247–253CrossRefPubMed Seow KM, Huang LW, Lin YH, et al. (2004) Caesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol 23:247–253CrossRefPubMed
6.
go back to reference Osborn DA, Williams TR, Craig BM (2012) Cesarean scar pregnancy: sonographic and magnetic resonance imaging findings, complications, and treatment. J Ultrasound Med 31(9):1449–1456PubMed Osborn DA, Williams TR, Craig BM (2012) Cesarean scar pregnancy: sonographic and magnetic resonance imaging findings, complications, and treatment. J Ultrasound Med 31(9):1449–1456PubMed
7.
go back to reference Rosen T (2008) Placenta accreta and cesarean scar pregnancy: overlooked costs of the rising cesarean section rate. Clin Perinatol 35:519–529CrossRefPubMed Rosen T (2008) Placenta accreta and cesarean scar pregnancy: overlooked costs of the rising cesarean section rate. Clin Perinatol 35:519–529CrossRefPubMed
8.
go back to reference McKenna DA, Poder L, Goldman M, et al. (2008) Role of sonography in recognition, assessment and treatment of cesarean scar ectopic pregnancies. J Ultrasound Med 27:779–783PubMed McKenna DA, Poder L, Goldman M, et al. (2008) Role of sonography in recognition, assessment and treatment of cesarean scar ectopic pregnancies. J Ultrasound Med 27:779–783PubMed
9.
go back to reference Lim PS, Greenberg M, Edelson MI, et al. (2011) Utility of ultrasound and MRI in prenatal diagnosis of placenta accreta: a pilot study. Am J Roentgenol 197(6):1506–1513CrossRef Lim PS, Greenberg M, Edelson MI, et al. (2011) Utility of ultrasound and MRI in prenatal diagnosis of placenta accreta: a pilot study. Am J Roentgenol 197(6):1506–1513CrossRef
10.
go back to reference Baughman WC, Cortville JE, Shah RR (2008) Placenta accreta: spectrum of US and MR imaging findings. Radiographics 28(7):1905–1916CrossRefPubMed Baughman WC, Cortville JE, Shah RR (2008) Placenta accreta: spectrum of US and MR imaging findings. Radiographics 28(7):1905–1916CrossRefPubMed
11.
go back to reference Lax A, Prince MR, Mennitt KW, Schwebach JR, Budorick NE (2007) The value of specific MRI features in the evaluation of suspected placental invasion. Magn Reson Imaging 25:87–93CrossRefPubMed Lax A, Prince MR, Mennitt KW, Schwebach JR, Budorick NE (2007) The value of specific MRI features in the evaluation of suspected placental invasion. Magn Reson Imaging 25:87–93CrossRefPubMed
12.
go back to reference Ben Nagi J, Helmy S, Ofili-Yebovi D, et al. (2007) Reproductive outcomes of women with a previous history of Caesarean scar ectopic pregnancies. Hum Reprod 22(7):2012–2015CrossRefPubMed Ben Nagi J, Helmy S, Ofili-Yebovi D, et al. (2007) Reproductive outcomes of women with a previous history of Caesarean scar ectopic pregnancies. Hum Reprod 22(7):2012–2015CrossRefPubMed
13.
go back to reference Kung FT, Lin H, Hsu TY, et al. (2004) Differential diagnosis of suspected cervical pregnancy and conservative treatment with the combination of laparoscopy-assisted uterine artery ligation and hysteroscopic endocervical resection. Fertil Steril 81:1642–1649CrossRefPubMed Kung FT, Lin H, Hsu TY, et al. (2004) Differential diagnosis of suspected cervical pregnancy and conservative treatment with the combination of laparoscopy-assisted uterine artery ligation and hysteroscopic endocervical resection. Fertil Steril 81:1642–1649CrossRefPubMed
14.
go back to reference Lin EP, Bhatt S, Dogra VS (2008) Diagnostic clues to ectopic pregnancy. Radiographics 28:1661–1671CrossRefPubMed Lin EP, Bhatt S, Dogra VS (2008) Diagnostic clues to ectopic pregnancy. Radiographics 28:1661–1671CrossRefPubMed
15.
go back to reference Maymon R, Halperin R, Mendlovic S, et al. (2004) Ectopic pregnancies in a caesarean scar: review of the medical approach to an iatrogenic complication. Hum Reprod Update 10:515–523CrossRefPubMed Maymon R, Halperin R, Mendlovic S, et al. (2004) Ectopic pregnancies in a caesarean scar: review of the medical approach to an iatrogenic complication. Hum Reprod Update 10:515–523CrossRefPubMed
16.
go back to reference Vial Y, Petignat P, Hohlfeld P (2000) Pregnancy in a caesarean scar. Ultrasound Obstet Gynecol 16:592–593CrossRefPubMed Vial Y, Petignat P, Hohlfeld P (2000) Pregnancy in a caesarean scar. Ultrasound Obstet Gynecol 16:592–593CrossRefPubMed
17.
go back to reference Sadeghi H, Rutherford T, Rackow B, et al. (2010) Cesarean scar ectopic pregnancy: case series and review of the literature. Am J Perinatol 27:111–120CrossRefPubMed Sadeghi H, Rutherford T, Rackow B, et al. (2010) Cesarean scar ectopic pregnancy: case series and review of the literature. Am J Perinatol 27:111–120CrossRefPubMed
18.
go back to reference Yela AA, Marchiani N (2013) Conservative management of ectopic pregnancy in cesarean scar: case report. Rev Bras Ginecol Obstet 35:233–237CrossRefPubMed Yela AA, Marchiani N (2013) Conservative management of ectopic pregnancy in cesarean scar: case report. Rev Bras Ginecol Obstet 35:233–237CrossRefPubMed
19.
go back to reference Uysal F, Uysal A, Adam G (2013) Cesarean scar pregnancy: diagnosis, management, and follow-up. J Ultrasound Med 32:1295–1300CrossRefPubMed Uysal F, Uysal A, Adam G (2013) Cesarean scar pregnancy: diagnosis, management, and follow-up. J Ultrasound Med 32:1295–1300CrossRefPubMed
20.
go back to reference Liu H, Leng J, Shi H, Lang J (2010) Expectant treatment of caesarean scar pregnancy: two cases reports and a glimpse at the natural courses. Arch Gynecol Obstet 282:455–458CrossRefPubMed Liu H, Leng J, Shi H, Lang J (2010) Expectant treatment of caesarean scar pregnancy: two cases reports and a glimpse at the natural courses. Arch Gynecol Obstet 282:455–458CrossRefPubMed
21.
go back to reference Hong SC, Lau MS, Yam PK (2011) Ectopic pregnancy in previous caesarean section scar. Singapore Med J 52:e115–e117PubMed Hong SC, Lau MS, Yam PK (2011) Ectopic pregnancy in previous caesarean section scar. Singapore Med J 52:e115–e117PubMed
22.
go back to reference Kutuk MS, Uysal G, Dolanbay M, Ozgun MT (2014) Successful medical treatment of cesarean scar ectopic pregnancies with systemic multi-dose methotrexate: single-center experience. J Obstet Gynaecol Res 40:1700–1706CrossRefPubMed Kutuk MS, Uysal G, Dolanbay M, Ozgun MT (2014) Successful medical treatment of cesarean scar ectopic pregnancies with systemic multi-dose methotrexate: single-center experience. J Obstet Gynaecol Res 40:1700–1706CrossRefPubMed
23.
go back to reference Wang JH, Xu KH, Lin J, Xu JY, Wu RJ (2009) Methotrexate therapy for cesarean section scar pregnancy with and without suction curettage. Fertil Steril 92:1208–1213CrossRefPubMed Wang JH, Xu KH, Lin J, Xu JY, Wu RJ (2009) Methotrexate therapy for cesarean section scar pregnancy with and without suction curettage. Fertil Steril 92:1208–1213CrossRefPubMed
24.
go back to reference Lian F, Wang Y, Chen W, et al. (2012) Uterine artery embolization combined with local methotrexate and systemic methotrexate for treatment of cesarean scar pregnancy with different ultrasonographic pattern. Cardiovasc Intervent Radiol 35:286–291CrossRefPubMed Lian F, Wang Y, Chen W, et al. (2012) Uterine artery embolization combined with local methotrexate and systemic methotrexate for treatment of cesarean scar pregnancy with different ultrasonographic pattern. Cardiovasc Intervent Radiol 35:286–291CrossRefPubMed
25.
go back to reference Ravhon A, Ben-Chetrit A, Rabinowitz R, et al. (1997) Successful methotrexate treatment of a viable pregnancy in a thin uterine scar. Br J Obstet Gynaecol 104:628–629CrossRefPubMed Ravhon A, Ben-Chetrit A, Rabinowitz R, et al. (1997) Successful methotrexate treatment of a viable pregnancy in a thin uterine scar. Br J Obstet Gynaecol 104:628–629CrossRefPubMed
26.
go back to reference Shufaro Y, Nadjari M (2001) Implantation of a gestational sac in a cesarean section scar. Fertile Steril 75:1217CrossRef Shufaro Y, Nadjari M (2001) Implantation of a gestational sac in a cesarean section scar. Fertile Steril 75:1217CrossRef
27.
go back to reference Flystra DL, Pound-Chang T, Miller MG, et al. (2002) Ectopic pregnancy within a caesarean delivery scar: a case report. Am J Obstet Gynecol 187:302–304 (35)CrossRef Flystra DL, Pound-Chang T, Miller MG, et al. (2002) Ectopic pregnancy within a caesarean delivery scar: a case report. Am J Obstet Gynecol 187:302–304 (35)CrossRef
28.
go back to reference Fylstra DL (2002) Ectopic pregnancy within a caesarean scar: a review. Obstet Gynecol Surv 57:537–543CrossRefPubMed Fylstra DL (2002) Ectopic pregnancy within a caesarean scar: a review. Obstet Gynecol Surv 57:537–543CrossRefPubMed
29.
go back to reference Cok T, Kalayci H, Ozdemir H (2015) Transvaginal ultrasound-guided local methotrexate administration as the first-line treatment for cesarean scar pregnancy: follow-up of 18 cases. J Obstet Gynaecol Res 41(5):803–808CrossRefPubMed Cok T, Kalayci H, Ozdemir H (2015) Transvaginal ultrasound-guided local methotrexate administration as the first-line treatment for cesarean scar pregnancy: follow-up of 18 cases. J Obstet Gynaecol Res 41(5):803–808CrossRefPubMed
30.
go back to reference Peng P, Gui T, Liu X (2015) Comparative efficacy and safety of local and systemic methotrexate injection in cesarean scar pregnancy. Ther Clin Risk Manag 11:137–142PubMedCentralPubMed Peng P, Gui T, Liu X (2015) Comparative efficacy and safety of local and systemic methotrexate injection in cesarean scar pregnancy. Ther Clin Risk Manag 11:137–142PubMedCentralPubMed
31.
go back to reference Timor-Tritsch IE, Monteagudo A, Santos R (2012) The diagnosis, treatment and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol 207(1):44.e1–44.e13CrossRef Timor-Tritsch IE, Monteagudo A, Santos R (2012) The diagnosis, treatment and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol 207(1):44.e1–44.e13CrossRef
32.
go back to reference Hasewaga J, Izuka K, Matsuoka R, et al. (2005) Limitations of conservative treatment for repeat caesarean scar pregnancy. Ultrasound Obstet Gynecol 25:310–311CrossRef Hasewaga J, Izuka K, Matsuoka R, et al. (2005) Limitations of conservative treatment for repeat caesarean scar pregnancy. Ultrasound Obstet Gynecol 25:310–311CrossRef
33.
go back to reference Stevens EE, Ogburn P (2011) Cesarean scar ectopic pregnancy: a case report of failed combination local and systemic methotrexate management requiring surgical intervention. J Reprod Med 56:356–358PubMed Stevens EE, Ogburn P (2011) Cesarean scar ectopic pregnancy: a case report of failed combination local and systemic methotrexate management requiring surgical intervention. J Reprod Med 56:356–358PubMed
34.
go back to reference Brasic N, Warden M, Vargas JE (2013) Conservative management of cesarean scar pregnancy with sonographically guided transvaginal methotrexate injection. J Ultrasound Med 32:1061–1063CrossRefPubMed Brasic N, Warden M, Vargas JE (2013) Conservative management of cesarean scar pregnancy with sonographically guided transvaginal methotrexate injection. J Ultrasound Med 32:1061–1063CrossRefPubMed
35.
go back to reference Wang J, Xu K, Lin J, et al. (2009) Methotrexate therapy for caesarean section scar pregnancy with or without suction curettage. Fertile Steril 92:1208–1213CrossRef Wang J, Xu K, Lin J, et al. (2009) Methotrexate therapy for caesarean section scar pregnancy with or without suction curettage. Fertile Steril 92:1208–1213CrossRef
36.
go back to reference Shao MJ, Hu M, Hu MX (2013) Conservative management of cesarean scar pregnancy by local injection of ethanol under hysteroscopic guidance. Int J Gynaecol Obstet 121:281–282CrossRefPubMed Shao MJ, Hu M, Hu MX (2013) Conservative management of cesarean scar pregnancy by local injection of ethanol under hysteroscopic guidance. Int J Gynaecol Obstet 121:281–282CrossRefPubMed
37.
go back to reference Shen L, Tan A, Zhu H, et al. (2012) Bilateral uterine artery chemoembolization with methotrexate for cesarean scar pregnancy. Am J Obstet Gynecol 207:386.e1–386.e6CrossRef Shen L, Tan A, Zhu H, et al. (2012) Bilateral uterine artery chemoembolization with methotrexate for cesarean scar pregnancy. Am J Obstet Gynecol 207:386.e1–386.e6CrossRef
38.
go back to reference Takeda A, Koyama K, Imoto S, et al. (2010) Diagnostic multimodal imaging and therapeutic transcatheter arterial chembolization for conservative management of hemorrhagic caesarean scar pregnancy. Eur J Obstet Gynecol Reprod Biol 152(2):152–156CrossRefPubMed Takeda A, Koyama K, Imoto S, et al. (2010) Diagnostic multimodal imaging and therapeutic transcatheter arterial chembolization for conservative management of hemorrhagic caesarean scar pregnancy. Eur J Obstet Gynecol Reprod Biol 152(2):152–156CrossRefPubMed
39.
go back to reference Pyra K, Wozniak S, Szkodziak P, et al. (2012) Uterine artery embolisation in massive vaginal bleeding in ectopic pregnancy: case report. Przegl Lek 69:399–401PubMed Pyra K, Wozniak S, Szkodziak P, et al. (2012) Uterine artery embolisation in massive vaginal bleeding in ectopic pregnancy: case report. Przegl Lek 69:399–401PubMed
40.
go back to reference Wu X, Zhang X, Zhu J, et al. (2012) Caesarean scar pregnancy: comparative efficacy and safety of treatment by uterine artery chemoembolization and systemic methotrexate injection. Eur J Obstet Gynecol Reprod Biol 161:75–79CrossRefPubMed Wu X, Zhang X, Zhu J, et al. (2012) Caesarean scar pregnancy: comparative efficacy and safety of treatment by uterine artery chemoembolization and systemic methotrexate injection. Eur J Obstet Gynecol Reprod Biol 161:75–79CrossRefPubMed
41.
go back to reference Li C, Li C, Feng D, et al. (2011) Transcatheter arterial chemoembolization versus systemic methotrexate for the management of cesarean scar pregnancy. Int J Gynaecol Obstet 113:178–182CrossRefPubMed Li C, Li C, Feng D, et al. (2011) Transcatheter arterial chemoembolization versus systemic methotrexate for the management of cesarean scar pregnancy. Int J Gynaecol Obstet 113:178–182CrossRefPubMed
42.
go back to reference Deans R, Abbot J (2010) Hysteroscopic management of cesarean scar ectopic pregnancy. Fertile Steril 93:1735–1740CrossRef Deans R, Abbot J (2010) Hysteroscopic management of cesarean scar ectopic pregnancy. Fertile Steril 93:1735–1740CrossRef
43.
go back to reference Chao A, Wang TH, Wang CJ, et al. (2005) Hysteroscopic management of caesarean scar pregnancy after unsuccessful methotrexate treatment. J Minim Invasive Gynecol 12:374–376CrossRefPubMed Chao A, Wang TH, Wang CJ, et al. (2005) Hysteroscopic management of caesarean scar pregnancy after unsuccessful methotrexate treatment. J Minim Invasive Gynecol 12:374–376CrossRefPubMed
44.
go back to reference Robinson J, Dayal M, Gindoff P, Frankfurter D (2009) A novel surgical treatment for caesarean scar pregnancy: laparoscopically assisted operative hysteroscopy. Fertil Steril 92:1497.e13–1497.e16CrossRef Robinson J, Dayal M, Gindoff P, Frankfurter D (2009) A novel surgical treatment for caesarean scar pregnancy: laparoscopically assisted operative hysteroscopy. Fertil Steril 92:1497.e13–1497.e16CrossRef
45.
go back to reference Valley MT, Pierce JG, Daniel TB, Kaunitz AM (1998) Cesarean scar pregnancy: imaging and treatment with a conservative surgery. Obstet Gynecol 91:838–840CrossRefPubMed Valley MT, Pierce JG, Daniel TB, Kaunitz AM (1998) Cesarean scar pregnancy: imaging and treatment with a conservative surgery. Obstet Gynecol 91:838–840CrossRefPubMed
46.
go back to reference Kang S, Park B, Kim Y, Ro D (2011) Surgical management of caesarean scar ectopic pregnancy: hysterotomy by transvaginal approach. Fertil Steril 96:e25–e28 (64)CrossRefPubMed Kang S, Park B, Kim Y, Ro D (2011) Surgical management of caesarean scar ectopic pregnancy: hysterotomy by transvaginal approach. Fertil Steril 96:e25–e28 (64)CrossRefPubMed
47.
go back to reference He M, Chen MH, Xie HZ, et al. (2011) Transvaginal removal of ectopic pregnancy tissue and repair of uterine defect for caesarean scar pregnancy. BJOG 118:1136–1139CrossRefPubMed He M, Chen MH, Xie HZ, et al. (2011) Transvaginal removal of ectopic pregnancy tissue and repair of uterine defect for caesarean scar pregnancy. BJOG 118:1136–1139CrossRefPubMed
48.
go back to reference Le A, Shan L, Xiao T, et al. (2013) Transvaginal surgical treatment of cesarean scar ectopic pregnancy. Arch Gynecol Obstet 287:791–796CrossRefPubMed Le A, Shan L, Xiao T, et al. (2013) Transvaginal surgical treatment of cesarean scar ectopic pregnancy. Arch Gynecol Obstet 287:791–796CrossRefPubMed
Metadata
Title
Cesarean scar ectopic pregnancy: imaging features, current treatment options, and clinical outcomes
Authors
Rehan M. Riaz
Todd R. Williams
Brian M. Craig
Daniel T. Myers
Publication date
01-10-2015
Publisher
Springer US
Published in
Abdominal Radiology / Issue 7/2015
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-015-0472-2

Other articles of this Issue 7/2015

Abdominal Radiology 7/2015 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.