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Published in: BMC Pregnancy and Childbirth 1/2019

Open Access 01-12-2019 | Gestational Diabetes | Case report

Breastfeeding a small for gestational age infant, complicated by maternal gestational diabetes: a case report

Authors: Alexandra D. George, Melvin C. L. Gay, Mary E. Wlodek, Donna T. Geddes

Published in: BMC Pregnancy and Childbirth | Issue 1/2019

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Abstract

Background

Small for gestational age (SGA) infants are those born small for their gestational age, with weight below the 10th percentile. Not only do SGA infants suffer growth issues after birth, they have elevated risk for the development of metabolic and cardiovascular diseases later in life. Current research has suggested that in cases of SGA infants, maternal milk and breastfeeding are not affected.

Case summary

The mother of an SGA infant was diagnosed with placental insufficiency and Gestational Diabetes Mellitus (GDM) during her pregnancy. The infant was born term, at 38 weeks 3 days, and SGA. The mother had a low milk supply and her milk composition differed from reference values such that the daily infant intake provided less than 50% of the required energy intake at 3 months.

Conclusion

In cases of SGA and/or GDM, maternal milk quality and quantity may be compromised. This requires follow-up in order to reduce the disease risk for SGA infants and the corresponding public health implications.
Literature
1.
go back to reference Nam HK. Small for gestational age and obesity: epidemiology and general risks. Ann Pediatr Endocrinol Metab. 2018;23(1):9–13.CrossRef Nam HK. Small for gestational age and obesity: epidemiology and general risks. Ann Pediatr Endocrinol Metab. 2018;23(1):9–13.CrossRef
2.
go back to reference Lin C-C, Santolaya-Forgas J. Current concepts of fetal growth restriction: part I. causes, classification, and pathophysiology. Obstet Gynecol. 1998;92(6):1044–55.PubMed Lin C-C, Santolaya-Forgas J. Current concepts of fetal growth restriction: part I. causes, classification, and pathophysiology. Obstet Gynecol. 1998;92(6):1044–55.PubMed
3.
go back to reference Esakoff TF, Guillet A, Caughey AB. Does small for gestational age worsen outcomes in gestational diabetics? J Matern Fetal Neonatal Med. 2017;30(8):890–3.CrossRef Esakoff TF, Guillet A, Caughey AB. Does small for gestational age worsen outcomes in gestational diabetics? J Matern Fetal Neonatal Med. 2017;30(8):890–3.CrossRef
4.
go back to reference Risnes KR, Romundstad PR, Nilsen TI, Eskild A, Vatten LJ. Placental weight relative to birth weight and long-term cardiovascular mortality: findings from a cohort of 31,307 men and women. Am J Epidemiol. 2009;170(5):622–31.CrossRef Risnes KR, Romundstad PR, Nilsen TI, Eskild A, Vatten LJ. Placental weight relative to birth weight and long-term cardiovascular mortality: findings from a cohort of 31,307 men and women. Am J Epidemiol. 2009;170(5):622–31.CrossRef
5.
go back to reference Wen X, Triche EW, Hogan JW, Shenassa ED, Buka SL. Association between placental morphology and childhood systolic blood pressure. Hypertension. 2011;57(1):48–55.CrossRef Wen X, Triche EW, Hogan JW, Shenassa ED, Buka SL. Association between placental morphology and childhood systolic blood pressure. Hypertension. 2011;57(1):48–55.CrossRef
6.
go back to reference Torgersen KL, Curran CA. A systematic approach to the physiologic adaptations of pregnancy. Crit Care Nurs Q. 2006;29(1):2–19.CrossRef Torgersen KL, Curran CA. A systematic approach to the physiologic adaptations of pregnancy. Crit Care Nurs Q. 2006;29(1):2–19.CrossRef
7.
go back to reference Cho WK, Suh BK. Catch-up growth and catch-up fat in children born small for gestational age. Korean J Pediatr. 2016;59(1):1–7.CrossRef Cho WK, Suh BK. Catch-up growth and catch-up fat in children born small for gestational age. Korean J Pediatr. 2016;59(1):1–7.CrossRef
8.
go back to reference Baird J, Fisher D, Lucas P, Kleijnen J, Roberts H, Law C. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ (Clinical research ed). 2005;331(7522):929.CrossRef Baird J, Fisher D, Lucas P, Kleijnen J, Roberts H, Law C. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ (Clinical research ed). 2005;331(7522):929.CrossRef
9.
go back to reference Monteiro PO, Victora CG. Rapid growth in infancy and childhood and obesity in later life--a systematic review. Obes Rev. 2005;6(2):143–54.CrossRef Monteiro PO, Victora CG. Rapid growth in infancy and childhood and obesity in later life--a systematic review. Obes Rev. 2005;6(2):143–54.CrossRef
10.
go back to reference Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin N Am. 2013;60(1):49–74.CrossRef Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin N Am. 2013;60(1):49–74.CrossRef
11.
go back to reference Mitoulas LR, Kent JC, Cox DB, Owens RA, Sherriff JL, Hartmann PE. Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. Br J Nutr. 2002;88(1):29–37.CrossRef Mitoulas LR, Kent JC, Cox DB, Owens RA, Sherriff JL, Hartmann PE. Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. Br J Nutr. 2002;88(1):29–37.CrossRef
12.
go back to reference Kent JC, Mitoulas LR, Cregan MD, Ramsay DT, Doherty DA, Hartmann PE. Volume and frequency of breastfeedings and fat content of breast milk throughout the day. Pediatrics. 2006;117(3):e387–95.CrossRef Kent JC, Mitoulas LR, Cregan MD, Ramsay DT, Doherty DA, Hartmann PE. Volume and frequency of breastfeedings and fat content of breast milk throughout the day. Pediatrics. 2006;117(3):e387–95.CrossRef
13.
go back to reference Briffa JF, O'Dowd R, Moritz KM, Romano T, Jedwab LR, McAinch AJ, et al. Uteroplacental insufficiency reduces rat plasma leptin concentrations and alters placental leptin transporters: ameliorated with enhanced milk intake and nutrition. J Physiol. 2017;595(11):3389–407.CrossRef Briffa JF, O'Dowd R, Moritz KM, Romano T, Jedwab LR, McAinch AJ, et al. Uteroplacental insufficiency reduces rat plasma leptin concentrations and alters placental leptin transporters: ameliorated with enhanced milk intake and nutrition. J Physiol. 2017;595(11):3389–407.CrossRef
14.
go back to reference Lubetzky R, Argov-Argaman N, Mimouni FB, Armoni Domany K, Shiff Y, Berkovitz Z, et al. Fatty acids composition of human milk fed to small for gestational age infants. J Matern Fetal Neonatal Med. 2016;29(18):3041–4.PubMed Lubetzky R, Argov-Argaman N, Mimouni FB, Armoni Domany K, Shiff Y, Berkovitz Z, et al. Fatty acids composition of human milk fed to small for gestational age infants. J Matern Fetal Neonatal Med. 2016;29(18):3041–4.PubMed
15.
go back to reference Domany KA, Mandel D, Kedem MH, Lubetzky R. Breast milk fat content of mothers to small-for-gestational-age infants. J Perinatol: official journal of the California Perinatal Association. 2015;35(6):444–6.CrossRef Domany KA, Mandel D, Kedem MH, Lubetzky R. Breast milk fat content of mothers to small-for-gestational-age infants. J Perinatol: official journal of the California Perinatal Association. 2015;35(6):444–6.CrossRef
16.
go back to reference Phattraprayoon N, Kraisonsin N, Kanjanapattanakul W. Comparison of breast milk compositions among mothers delivering small-for-gestational age, appropriate-for-gestational age, and large-for-gestational age infants. Breastfeed Med. 2018;0(0):null. Phattraprayoon N, Kraisonsin N, Kanjanapattanakul W. Comparison of breast milk compositions among mothers delivering small-for-gestational age, appropriate-for-gestational age, and large-for-gestational age infants. Breastfeed Med. 2018;0(0):null.
18.
go back to reference Kent JC, Mitoulas L, Cox DB, Owens RA, Hartmann PE. Breast volume and milk production during extended lactation in women. Exp Physiol. 1999;84(2):435–47.CrossRef Kent JC, Mitoulas L, Cox DB, Owens RA, Hartmann PE. Breast volume and milk production during extended lactation in women. Exp Physiol. 1999;84(2):435–47.CrossRef
19.
go back to reference Lucas A, Gibbs JA, Lyster RL, Baum JD. Creamatocrit: simple clinical technique for estimating fat concentration and energy value of human milk. Br Med J. 1978;1(6119):1018–20.CrossRef Lucas A, Gibbs JA, Lyster RL, Baum JD. Creamatocrit: simple clinical technique for estimating fat concentration and energy value of human milk. Br Med J. 1978;1(6119):1018–20.CrossRef
20.
go back to reference Butte NF, Garza C, Smith EO, Nichols BL. Human milk intake and growth in exclusively breast-fed infants. J Pediatr. 1984;104(2):187–95.CrossRef Butte NF, Garza C, Smith EO, Nichols BL. Human milk intake and growth in exclusively breast-fed infants. J Pediatr. 1984;104(2):187–95.CrossRef
21.
go back to reference Eriksson JG, Kajantie E, Osmond C, Thornburg K, Barker DJ. Boys live dangerously in the womb. Am J Hum Biol. 2010;22(3):330–5.CrossRef Eriksson JG, Kajantie E, Osmond C, Thornburg K, Barker DJ. Boys live dangerously in the womb. Am J Hum Biol. 2010;22(3):330–5.CrossRef
22.
go back to reference Martorell R. The nature of child malnutrition and its long-term implications. Food Nutr Bull. 1999;20(3):288–92.CrossRef Martorell R. The nature of child malnutrition and its long-term implications. Food Nutr Bull. 1999;20(3):288–92.CrossRef
23.
24.
go back to reference Gridneva Z, Tie W, Rea A, Lai C, Ward L, Murray K, et al. Human milk casein and whey protein and infant body composition over the first 12 months of lactation. Nutrients. 2018;10(9):1332.CrossRef Gridneva Z, Tie W, Rea A, Lai C, Ward L, Murray K, et al. Human milk casein and whey protein and infant body composition over the first 12 months of lactation. Nutrients. 2018;10(9):1332.CrossRef
25.
go back to reference Kramer MS, Aboud F, Mironova E, Vanilovich I, Platt RW, Matush L, et al. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008;65(5):578–84.CrossRef Kramer MS, Aboud F, Mironova E, Vanilovich I, Platt RW, Matush L, et al. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008;65(5):578–84.CrossRef
26.
go back to reference Hadders-Algra M. Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. Am J Clin Nutr. 2011;94(6 Suppl):1874S–9S.CrossRef Hadders-Algra M. Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. Am J Clin Nutr. 2011;94(6 Suppl):1874S–9S.CrossRef
27.
go back to reference Jensen R. Handbook of milk composition. San Diego: Academic Press Google Scholar; 1995. Jensen R. Handbook of milk composition. San Diego: Academic Press Google Scholar; 1995.
28.
go back to reference Cheong JN, Wlodek ME, Moritz KM, Cuffe JS. Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations. J Physiol. 2016;594(17):4727–40.CrossRef Cheong JN, Wlodek ME, Moritz KM, Cuffe JS. Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations. J Physiol. 2016;594(17):4727–40.CrossRef
29.
go back to reference Mazzuca MQ, Tare M, Parkington HC, Dragomir NM, Parry LJ, Wlodek ME. Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy. J Physiol. 2012;590(14):3375–88.CrossRef Mazzuca MQ, Tare M, Parkington HC, Dragomir NM, Parry LJ, Wlodek ME. Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy. J Physiol. 2012;590(14):3375–88.CrossRef
30.
go back to reference Nommsen-Rivers LA. Does insulin explain the relation between maternal obesity and poor lactation outcomes? An overview of the literature. Adv Nutr. 2016;7(2):407–14.CrossRef Nommsen-Rivers LA. Does insulin explain the relation between maternal obesity and poor lactation outcomes? An overview of the literature. Adv Nutr. 2016;7(2):407–14.CrossRef
31.
go back to reference Neville MC, Webb P, Ramanathan P, Mannino MP, Pecorini C, Monks J, et al. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab. 2013;305(9):E1103–14.CrossRef Neville MC, Webb P, Ramanathan P, Mannino MP, Pecorini C, Monks J, et al. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab. 2013;305(9):E1103–14.CrossRef
32.
go back to reference Nommsen-Rivers LA, Chantry CJ, Peerson JM, Cohen RJ, Dewey KG. Delayed onset of lactogenesis among first-time mothers is related to maternal obesity and factors associated with ineffective breastfeeding. Am J Clin Nutr. 2010;92(3):574–84.CrossRef Nommsen-Rivers LA, Chantry CJ, Peerson JM, Cohen RJ, Dewey KG. Delayed onset of lactogenesis among first-time mothers is related to maternal obesity and factors associated with ineffective breastfeeding. Am J Clin Nutr. 2010;92(3):574–84.CrossRef
33.
go back to reference Riddle SW, Nommsen-Rivers LA. A case control study of diabetes during pregnancy and low milk supply. Breastfeed Med. 2016;11(2):80–5.CrossRef Riddle SW, Nommsen-Rivers LA. A case control study of diabetes during pregnancy and low milk supply. Breastfeed Med. 2016;11(2):80–5.CrossRef
34.
go back to reference Lemay DG, Ballard OA, Hughes MA, Morrow AL, Horseman ND, Nommsen-Rivers LA. RNA sequencing of the human Milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation. PLoS One. 2013;8(7):e67531.CrossRef Lemay DG, Ballard OA, Hughes MA, Morrow AL, Horseman ND, Nommsen-Rivers LA. RNA sequencing of the human Milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation. PLoS One. 2013;8(7):e67531.CrossRef
Metadata
Title
Breastfeeding a small for gestational age infant, complicated by maternal gestational diabetes: a case report
Authors
Alexandra D. George
Melvin C. L. Gay
Mary E. Wlodek
Donna T. Geddes
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2019
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-019-2366-8

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