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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2019

Open Access 01-12-2019 | Pre-Eclampsia | Research article

Non-additive effects of ACVR2A in preeclampsia in a Philippine population

Authors: Melissa D. Amosco, Gloria R. Tavera, Van Anthony M. Villar, Justin Michael A. Naniong, Lara Marie G. David-Bustamante, Scott M. Williams, Pedro A. Jose, Cynthia P. Palmes-Saloma

Published in: BMC Pregnancy and Childbirth | Issue 1/2019

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Abstract

Background

Multiple interrelated pathways contribute to the pathogenesis of preeclampsia, and variants in susceptibility genes may play a role among Filipinos, an ethnically distinct group with high prevalence of the disease. The objective of this study was to examine the association between variants in maternal candidate genes and the development of preeclampsia in a Philippine population.

Methods

A case-control study involving 29 single nucleotide polymorphisms (SNPs) in 21 candidate genes was conducted in 150 patients with preeclampsia (cases) and 175 women with uncomplicated normal pregnancies (controls). Genotyping for the GRK4 and DRD1 gene variants was carried out using the TaqMan Assay, and all other variants were assayed using the Sequenom MassARRAY Iplex Platform. PLINK was used for SNP association testing. Multilocus association analysis was performed using multifactor dimensionality reduction (MDR) analysis.

Results

Among the clinical factors, older age (P <  1 × 10–4), higher BMI (P <  1 × 10–4), having a new partner (P = 0.006), and increased time interval from previous pregnancy (P = 0.018) associated with preeclampsia. The MDR algorithm identified the genetic variant ACVR2A rs1014064 as interacting with age and BMI in association with preeclampsia among Filipino women.

Conclusions

The MDR algorithm identified an interaction between age, BMI and ACVR2A rs1014064, indicating that context among genetic variants and demographic/clinical factors may be crucial to understanding the pathogenesis of preeclampsia among Filipino women.
Appendix
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Metadata
Title
Non-additive effects of ACVR2A in preeclampsia in a Philippine population
Authors
Melissa D. Amosco
Gloria R. Tavera
Van Anthony M. Villar
Justin Michael A. Naniong
Lara Marie G. David-Bustamante
Scott M. Williams
Pedro A. Jose
Cynthia P. Palmes-Saloma
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Pre-Eclampsia
Published in
BMC Pregnancy and Childbirth / Issue 1/2019
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-018-2152-z

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