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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2017

Open Access 01-12-2017 | Case report

Pregnancy in fanconi anaemia with bone marrow failure: a case report and review of the literature

Authors: Flavia Sorbi, Federico Mecacci, Alessandro Di Filippo, Massimiliano Fambrini

Published in: BMC Pregnancy and Childbirth | Issue 1/2017

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Abstract

Background

Fanconi anaemia is a rare inherited disease characterized by congenital abnormalities, progressive bone marrow failure and predisposition to malignancy. Successful pregnancies in transplanted patients have been reported. In this paper we will describe the pregnancy of a patient with Fanconi anaemia without transplantation.

Case presentation

A 34-year-old nulliparous woman with Fanconi anaemia was referred to our institution. Pregnancy was complicated by progressive pancytopenia and two severe infections. C-section was performed at 36 weeks. Both infant and mother are well.

Conclusion

Successful pregnancy in a Fanconi anaemia patient with bone marrow failure is possible. The mode of delivery in patients with bone marrow failure should be determined by obstetric indications. The case highlights the safe outcome of the pregnancy with strict clinical and laboratory control by a multidisciplinary team.
Literature
1.
Nabhan SK, Bitencourt MA, Duval M, Abecasis M, Dufour C, Boudjedir K, et al. Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients. Haematologica. 2010;95:1783–7.CrossRefPubMedPubMedCentral
2.
Ascarelli MH, Emerson ES, Bigelow CL, Martin JN. Aplastic anemia and immune mediated thrombocytopenia: concurrent complications encountered in the third trimester of pregnancy. Obstet Gynecol. 1998;91:803–6.PubMed
3.
Shin JE, Lee Y, Kim SJ, Shin JC. Association of severe thrombocytopenia and poor prognosis in pregnancies with aplastic anemia. PLoS One. 2014;9:e103066.CrossRefPubMedPubMedCentral
4.
Tichelli A, Socié G, Marsh J, Barge R, Frickhofen N, McCann S, et al. Outcome of pregnancy and disease course among women with aplastic anemia treated with immunosuppression. Ann Intern Med. 2002;137:164–72.CrossRefPubMed
5.
Turrentine M. Practice Bulletin No. 166: Thrombocytopenia in Pregnancy. Obstet Gynecol. 2016;128:e43–53.
6.
Zeidler C, Grote UA, Nickel A, Brand B, Carlsson G, Cortesão E, et al. Outcome and management of pregnancies in severe chronic neutropenia patients by the european branch of the severe chronic neutropenia international registry. Haematologica. 2014;99:1395–402.CrossRefPubMedPubMedCentral
7.
Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2013;346:f3443.CrossRefPubMedPubMedCentral
8.
Potet J, Thome A, Curis E, Arnaud FX, Weber-Donat G, Valbousquet L, et al. Peripherally inserted central catheter placement in cancer patients with profound thrombocytopaenia: a prospective analysis. Eur Radiol. 2013;23:2042–8.CrossRefPubMed
Metadata
Title
Pregnancy in fanconi anaemia with bone marrow failure: a case report and review of the literature
Authors
Flavia Sorbi
Federico Mecacci
Alessandro Di Filippo
Massimiliano Fambrini
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2017
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-017-1236-5

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