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European Radiology
Published in: European Radiology 7/2013

01-07-2013 | Vascular-Interventional

Peripherally inserted central catheter placement in cancer patients with profound thrombocytopaenia: a prospective analysis

Authors: Julien Potet, Alphonse Thome, Emmanuel Curis, François-Xavier Arnaud, Gabrielle Weber-Donat, Laura Valbousquet, Evelyne Peroux, Eric Flor, Christophe Dody, Johanna Konopacki, Jean Valère Malfuson, Cecile Cartry, Marion Lahutte, Thierry de Revel, Jacques Baccialone, Christophe A. Teriitehau

Published in: European Radiology | Issue 7/2013

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Abstract

Objective

No studies have specifically evaluated the safety of peripherally inserted central catheter (PICC) placement in patients with profound thrombocytopaenia. We prospectively determined the frequency of haemorrhagic complications of PICC placement in cancer patients with uncorrected profound thrombocytopaenia.

Methods

Profound thrombocytopaenia was defined as a platelet count <50 × 109/l. No patients received transfusions before or after the procedure. Three types of adverse effects were analysed: minor oozing, mild haematoma and major haemorrhage.

Results

One hundred and forty-three PICC implantations in 101 cancer patients were prospectively included in the study: seven patients (7 %) had a solid tumour and 94 (93 %) a haematological malignancy. Among these 143 procedures in thrombocytopaenic patients, 93 (65 %) were performed with a platelet count 20–50 × 109/l and 50 (35 %) had lower than 20 × 109/l. No major haemorrhage was observed. Minor oozing was observed in six implantations (4 %) and mild haematoma in two (1.5 %), for a total of eight minor haemorrhagic adverse events (5.5 %). In patients with a platelet count <20 × 109/l, 1/50 (2 %) had minor oozing and none had minor haematoma.

Conclusions

In cancer patients with uncorrected profound thrombocytopaenia, the incidence of adverse events after PICC implantation was low, and was limited to minor haemorrhagic adverse events.

Key Points

• PICC placement has high technical success in profound thrombocytopaenic cancer patients.
• Few adverse events are encountered after PICC placement, limited to minor haemorrhage.
• PICC placement does not routinely require platelet transfusion in patients with thrombocytopaenia.
• Such PICC placement still seems safe when the platelet count is <20 × 10 9 /l.
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Metadata
Title
Peripherally inserted central catheter placement in cancer patients with profound thrombocytopaenia: a prospective analysis
Authors
Julien Potet
Alphonse Thome
Emmanuel Curis
François-Xavier Arnaud
Gabrielle Weber-Donat
Laura Valbousquet
Evelyne Peroux
Eric Flor
Christophe Dody
Johanna Konopacki
Jean Valère Malfuson
Cecile Cartry
Marion Lahutte
Thierry de Revel
Jacques Baccialone
Christophe A. Teriitehau
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
European Radiology / Issue 7/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-013-2778-1

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