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BMC Neurology

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Open Access 01-12-2021 | Arterial Occlusive Disease | Research article

The association between retinal vessel abnormalities and H-type hypertension

Authors: Kuankuan Huang, Zhixiang Zhang, Shan Huang, Yanwen Jia, Min Zhang, Wenwei Yun

Published in: BMC Neurology | Issue 1/2021

Abstract

Background

This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities.

Methods

Hypertensive patients were retrospectively enrolled in this study. According to plasma homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension groups. The diameter of retinal vessels and retinopathy were evaluated by retinal fundus photography. The differences of retinal vessel abnormalities between H-type hypertension and isolated hypertension were investigated by univariate and multivariate regression.

Results

A total of 191 hypertensive patients were included, of which 86 were with isolated hypertension and 105 with H-type hypertension. The H-type hypertension group had a higher ratio of retinopathy(P = 0.004) and higher degree of retinal arteriosclerosis (P = 0.005) than the isolated hypertension group. CRAE (107.47 ± 13.99µ m vs. 113.49 ± 11.72µ m, P = 0.002) and AVR (0.55 ± 0.06 vs. 0.58 ± 0.06, P = 0.001) were smaller in H-type hypertension group than those in isolated hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension was an independent risk factor of retinopathy (OR, 2.259; 95%CI, 1.165—4.378; P = 0.016), CRAE (β=-5.669; 95%CI, -9.452—-1.886; P = 0.004), and AVR (β=-0.023; 95%CI, -0.039—-0.007; P = 0.005).

Conclusions

H-type hypertension is closely related to more retinal vessel abnormalities than isolated hypertension. Controlling H-type hypertension may reduce the risk of small vascular damage.

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Title: The association between retinal vessel abnormalities and H-type hypertension
Authors: Kuankuan Huang
Zhixiang Zhang
Shan Huang
Yanwen Jia
Min Zhang
Wenwei Yun
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Arterial Occlusive Disease
Hypertension
Hypertension
Published in: BMC Neurology / Issue 1/2021
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-02029-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The association between retinal vessel abnormalities and H-type hypertension

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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