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BMC Neurology

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Open Access 01-12-2015 | Research article

Evaluation of traumatic brain injury by optical technique

Authors: Bor-Shyh Lin, Che-Chuan Wang, Ming-Hsien Chang, Chung-Ching Chio

Published in: BMC Neurology | Issue 1/2015

Abstract

Background

Traumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death. However, there is paucity of information regarding changes in the physiologic state of humans or animals after brain shaking.

Methods

In this study, near-infrared spectroscopy (NIRS) was used to continuously monitor the concentration change of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) to understand changes in the physiological state during and after brain shaking. Laser Doppler flowmetry was also used to monitor changes in cerebral blood flow under TBI to supplement the investigation. Triphenyltetrazolium chloride (TTC) staining was used to monitor changes of infarction volume corresponding to different impact strengths.

Result

The experimental results indicated that concentration changes of HbO2 and total-hemoglobin (HbT) were significantly related to the impact strength. The infarction volume was also significantly related to the impact strength.

Conclusion

Therefore, the non-invasive monitoring of concentration changes in HbO₂, HbR, and HbT using NIRS may have a clinical application for the evaluation of TBI.

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Title: Evaluation of traumatic brain injury by optical technique
Authors: Bor-Shyh Lin
Che-Chuan Wang
Ming-Hsien Chang
Chung-Ching Chio
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2015
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-015-0465-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Evaluation of traumatic brain injury by optical technique

Abstract

Background

Methods

Result

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Result

Conclusion

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