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BMC Nephrology
Published in: BMC Nephrology 1/2017

Open Access 01-12-2017 | Case report

Case report - atypical hemolytic uremic syndrome triggered by influenza B

Authors: Robin Kobbe, Raphael Schild, Martin Christner, Jun Oh, Sebastian Loos, Markus J. Kemper

Published in: BMC Nephrology | Issue 1/2017

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Abstract

Background

Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.

Case presentation

A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.

Conclusion

Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
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Metadata
Title
Case report - atypical hemolytic uremic syndrome triggered by influenza B
Authors
Robin Kobbe
Raphael Schild
Martin Christner
Jun Oh
Sebastian Loos
Markus J. Kemper
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2017
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-017-0512-y

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