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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2016

Open Access 01-12-2016 | Software

An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited

Authors: Frank G. Zöllner, Markus Daab, Steven P. Sourbron, Lothar R. Schad, Stefan O. Schoenberg, Gerald Weisser

Published in: BMC Medical Imaging | Issue 1/2016

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Abstract

Background

Perfusion imaging has become an important image based tool to derive the physiological information in various applications, like tumor diagnostics and therapy, stroke, (cardio-) vascular diseases, or functional assessment of organs. However, even after 20 years of intense research in this field, perfusion imaging still remains a research tool without a broad clinical usage. One problem is the lack of standardization in technical aspects which have to be considered for successful quantitative evaluation; the second problem is a lack of tools that allow a direct integration into the diagnostic workflow in radiology.

Results

Five compartment models, namely, a one compartment model (1CP), a two compartment exchange (2CXM), a two compartment uptake model (2CUM), a two compartment filtration model (2FM) and eventually the extended Toft’s model (ETM) were implemented as plugin for the DICOM workstation OsiriX. Moreover, the plugin has a clean graphical user interface and provides means for quality management during the perfusion data analysis. Based on reference test data, the implementation was validated against a reference implementation. No differences were found in the calculated parameters.

Conclusion

We developed open source software to analyse DCE-MRI perfusion data. The software is designed as plugin for the DICOM Workstation OsiriX. It features a clean GUI and provides a simple workflow for data analysis while it could also be seen as a toolbox providing an implementation of several recent compartment models to be applied in research tasks. Integration into the infrastructure of a radiology department is given via OsiriX. Results can be saved automatically and reports generated automatically during data analysis ensure certain quality control.
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Metadata
Title
An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited
Authors
Frank G. Zöllner
Markus Daab
Steven P. Sourbron
Lothar R. Schad
Stefan O. Schoenberg
Gerald Weisser
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2016
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-016-0109-0

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