Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2021

Open Access 01-12-2021 | Expectoration | Case report

Pulmonary nocardiosis in a patient with pemphigus foliaceus: case report and literature review

Authors: Ning Luo, Shifan Tan, Xiaocai Li, Si Liu, Shivank Singh, Mafeng Chen, Weiye Yang, Yanhong He, Chunna Chen, Min Liang

Published in: BMC Infectious Diseases | Issue 1/2021

Login to get access

Abstract

Background

Nocardiosis is an uncommon opportunistic infection seen in immunocompromised patients or those with a dysfunctional immune system. Nocardia asteroides infection in patients with Pemphigus foliaceus (PF) has never been reported.

Case presentation

We report an interesting case of nocardiosis-characterized by pulmonary intra-cavitary infection, in a 54-year-old man with PF and diabetes mellitus. The man finally recovered from the infection.

Conclusions

This is the first case reporting pulmonary nocardiosis in a patient with PF. We recommend that physicians be aware of nocardiosis in patients with pemphigus as a possible cause of underlying infectious disease to avoid misdiagnoses and mismanagement.
Literature
1.
Murrell DF, Peña S, Joly P, Marinovic B, Hashimoto T, Diaz LA, et al. Diagnosis and management of pemphigus: recommendations of an international panel of experts. J Am Acad Dermatol. 2020;82(3):575–85.e1.PubMedCrossRef
2.
3.
Diaz LA, Sampaio SA, Rivitti EA, Martins CR, Cunha PR, Lombardi C, et al. Endemic pemphigus foliaceus (fogo selvagem). I. Clinical features and immunopathology. J Am Acad Dermatol. 1989;20(4):657–69.PubMedCrossRef
4.
5.
Robinson ND, Hashimoto T, Amagai M, Chan LS. The new pemphigus variants. J Am Acad Dermatol. 1999;40(5 Pt 1):649–71 quiz 72-3.PubMedCrossRef
6.
Alpsoy E, Akman-Karakas A, Uzun S. Geographic variations in epidemiology of two autoimmune bullous diseases: pemphigus and bullous pemphigoid. Arch Dermatol Res. 2015;307(4):291–8.PubMedCrossRef
7.
Carson PJ, Hameed A, Ahmed AR. Influence of treatment on the clinical course of pemphigus vulgaris. J Am Acad Dermatol. 1996;34(4):645–52.PubMedCrossRef
8.
Lederman ER, Crum NF. A case series and focused review of nocardiosis: clinical and microbiologic aspects. Medicine (Baltimore). 2004;83(5):300–13.CrossRef
9.
Tilak R, Agarwal D, Lahiri TK, Tilak V. Pulmonary nocardiosis presenting as fungal ball--a rare entity. J Infect Dev Ctries. 2008;2(2):143–5.PubMedCrossRef
10.
Safdar N, Kaul DR, Saint S. Clinical problem-solving. Into the woods. N Engl J Med. 2007;356(9):943–7.PubMedCrossRef
11.
12.
13.
Asilian A, Yoosefi A, Faghihi G. Cutaneous and pulmonary nocardiosis in pemphigus vulgaris: a rare complication of immunosuppressive therapy. Int J Dermatol. 2006;45(10):1204–6.PubMedCrossRef
14.
Murdock DK, Lookingbill DP. Immunosuppressive therapy of pemphigus vulgaris complicated by Nocardia pneumonia. Gold as an alternate therapy. Arch Dermatol. 1990;126(1):27–8.PubMedCrossRef
15.
16.
Miller RC, Felman YM. Pemphigus vulgaris and pulmonary nocardiosis. Arch Dermatol. 1967;96(5):548–51.PubMedCrossRef
17.
Martín FJ, Pérez-Bernal AM, Camacho F. Pemphigus vulgaris and disseminated nocardiosis. J Eur Acad Dermatol Venereol. 2000;14(5):416–8.PubMedCrossRef
18.
Chosidow O, Wolkenstein P, Bagot M, Girard-Pipau F, Brun-Buisson C, Fraitag S, et al. Nocardia asteroides septicemia in a pemphigus patient. Successful treatment with trimethoprim-sulfamethoxazole and amikacin association. Dermatologica. 1990;181(4):311–3.PubMedCrossRef
Metadata
Title
Pulmonary nocardiosis in a patient with pemphigus foliaceus: case report and literature review
Authors
Ning Luo
Shifan Tan
Xiaocai Li
Si Liu
Shivank Singh
Mafeng Chen
Weiye Yang
Yanhong He
Chunna Chen
Min Liang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-020-05673-5

Other articles of this Issue 1/2021

BMC Infectious Diseases 1/2021 Go to the issue

Case report

Case report: pulmonary nocardiosis caused by Nocardia exalbida in an immunocompetent patient

Case report

Adenosine deaminase negative pleural tuberculosis: a case report

Case report

Tuberculosis reactivation at ileum following immune checkpoint inhibition with pembrolizumab for metastatic nasopharyngeal carcinoma: a case report

Research article

Ambulatory induction phase treatment of cryptococcal meningitis in HIV integrated primary care clinics, Yangon, Myanmar

Research article

HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China

Research

Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits