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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2018

Open Access 01-12-2018 | Research article

Prevalence, intensity and factors associated with soil-transmitted helminths infections among preschool-age children in Hoima district, rural western Uganda

Authors: Silvestro Ojja, Stevens Kisaka, Michael Ediau, Doreen Tuhebwe, Angela N. Kisakye, Abdullah A. Halage, Richard K. Mugambe, Joan N. Mutyoba

Published in: BMC Infectious Diseases | Issue 1/2018

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Abstract

Background

Over 80% of morbidity due to soil-transmitted helminthiasis (STH) occurs in low-income countries. Children under 5 account for 20–30% of the burden in endemic areas. This study assessed the prevalence, intensity and factors associated with STH infections among preschool-age children (PSAC) in Hoima district, Uganda. The PSAC are particularly vulnerable because the chronicity of this condition usually affects their physical and mental growth and development.

Methods

A cross-sectional study was carried out among 562 PSAC (1–5 years old) in 6 counties of Hoima district using Expanded Program on Immunization (EPI) method. Stool samples from children were examined using the formol ether concentration technique for STH egg detection. Egg counts were represented as egg per gram (EPG). A structured questionnaire was used to collect information on factors associated with STH infection. Generalized linear models were used to analyze relationships between STH infection and associated factors.

Results

Overall STH prevalence was 26.5%. Hookworm infection was the most prevalent (18.5%), followed by A.lumbricoides (9.8%) and T.trichiura (0.5%). Prevalence of STH infection was significantly higher in children aged 5 years (Pearson chi-square test, p = 0.009) than in children aged 1 year. The general geometric mean (GM) counts for Hookworm infection was (696.1 EPG; range (530.3–913.8)) with girls having a higher GM (789.8 EPG; range (120–13,200)) than boys. Eating uncooked or unwashed vegetables (adj. Prevalence Ratio (PR) = 1.9, 95% CI: 1.3–2.7) and fruits (adj.PR = 1.8, 95% CI: 1.1–2.8), indiscriminate disposal of young children’s faeces (adj.PR = 1.5, 95% CI: 1.1–2.0); not washing hands after defecation (adj.PR = 2.6, 95% CI: 1.9–3.6); and not deworming children regularly (adj.PR = 1.4, 95% CI: 1.1–1.8) were significantly associated with STH infection.

Conclusion

The prevalence of Soil transmitted helminths infection among preschool-age children in Hoima district significantly increased with age. Poor hygiene, inadequate sanitation and irregular deworming were associated with STH infections among PSAC in the study area. Intense health education on the importance of hygienic practices, improved sanitation and regular deworming of PSAC should be integrated into prevention and control programs.
Appendix
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Literature
1.
WHO. Soil transmitted helminthiasis: estimates of the number of children needing preventive chemotherapy and number treated, 2009. Wkly Epidemiol Rec. 2011;25(86):257–68.
2.
Brooker S. Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers–a review. Int J Parasitol. 2010;40(10):1137–44.CrossRefPubMedPubMedCentral
3.
Pullan RL, Smith JL, Jasrasaria R, Brooker SJ. Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit Vectors. 2014;7(1):37.CrossRefPubMedPubMedCentral
4.
Knopp S, Stothard JR, Rollinson D, Mohammed KA, Khamis IS, Marti H, Utzinger J. From morbidity control to transmission control: time to change tactics against helminths on Unguja Island, Zanzibar. Acta Trop. 2013;128(2):412–22.CrossRefPubMed
5.
Nalugwa A, Olsen A, Tukahebwa M, Nuwaha F. Intestinal schistosomiasis among preschool children along the shores of Lake Victoria in Uganda. Acta Trop. 2015;142:115–21.CrossRefPubMed
6.
Ssentamu J, Alinaitwe E, Nyangoma J, Nsita G: Hoima water sanitation and hygiene Anual Report-2015. 2015.
7.
Brooker S, Kabatereine NB, Smith JL, Mupfasoni D, Mwanje MT, Ndayishimiye O, Lwambo NJ, Mbotha D, Karanja P, Mwandawiro C. International Journal of Health Geographics. Int J Health Geogr. 2009;8:42.CrossRefPubMedPubMedCentral
8.
Freeman M, Chard A, Nikolay B, Garn J, Okoyo C, Kihara J, Njenga S, Pullan R, Brooker S, Mwandawiro C. Associations between school-and household-level water, sanitation and hygiene conditions and soil-transmitted helminth infection among Kenyan school children. Parasit Vectors. 2015;8(1):412.CrossRefPubMedPubMedCentral
9.
Lwanga F, Kirunda BE, Orach CG. Intestinal helminth infections and nutritional status of children attending primary schools in Wakiso District, Central Uganda. Int J Environ Res Public Health. 2012;9(8):2910–21.CrossRefPubMed
10.
Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. J Clin Investig. 2008;118(4):1311–21.CrossRefPubMed
11.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet. 2006;367(9521):1521–32.CrossRefPubMed
12.
Dalal S, Beunza JJ, Volmink J, Adebamowo C, Bajunirwe F, Njelekela M, Mozaffarian D, Fawzi W, Willett W, Adami H-O. Non-communicable diseases in sub-Saharan Africa: what we know now. Int J Epidemiol. 2011;40(4):885–901.CrossRefPubMed
13.
Aikins A-G, Unwin N, Agyemang C, Allotey P, Campbell C, Arhinful D. tackling Africa's chronic disease burden: from the local to the global. Glob Health. 2010;6(1):5.CrossRef
14.
Muhumuza S, Olsen A, Katahoire A, Nuwaha F. Uptake of preventive treatment for intestinal schistosomiasis among school children in Jinja district, Uganda: a cross sectional study. PLoS One. 2013;8(5):e63438.CrossRefPubMedPubMedCentral
15.
Shivairo R, Muleke C, Mukabane D, Kumba J. Soil transmitted helminthes prevalence among pre-school age children in Elburgon municipality, Kenya. J Bio, Agri Health. 2014;4(21):36–41.
16.
Ojurongbe O, Oyesiji K, Ojo J, Odewale G, Adefioye O, Olowe A, Opaleye O, Bolaji O, Ojurongbe T. Soil transmitted helminth infections among primary school children in Ile-Ife southwest, Nigeria: a cross-sectional study. Int Res J Med Med Sci. 2014;2(1):6–10.
17.
Saboyá MI, Catalá L, Nicholls RS, Ault SK. Update on the mapping of prevalence and intensity of infection for soil-transmitted helminth infections in Latin America and the Caribbean: a call for action. PLoS Negl Trop Dis. 2013;7(9):e2419.CrossRefPubMedPubMedCentral
18.
Abera B, Alem G, Yimer M, Herrador Z. Epidemiology of soil-transmitted helminths, Schistosoma mansoni, and haematocrit values among schoolchildren in Ethiopia. The Journal of Infection in Developing Countries. 2013;7(03):253–60.CrossRefPubMed
19.
WHO: Prevention and control of Schistosomiasis and Soil-Transmitted Helminths. 2003.
20.
Parker M, Allen T. Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda. Health research policy and systems. 2011;9(1):3.CrossRefPubMedPubMedCentral
21.
Kabatereine NB, Brooker S, Koukounari A, Kazibwe F, Tukahebwa EM, Fleming FM, Zhang Y, Webster JP, Stothard JR, Fenwick A. Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bull World Health Organ. 2007;85(2):91–9.CrossRefPubMedPubMedCentral
22.
MOH: Uganda Ministry of Health Annual Report. 2015.
23.
Kabagambe D, Byenume F, Ruyonga J: Hoima District health Indicator Report-2015. 2015.
24.
Ruyonga J, Byanguma F, Kabagmbe D, Kugonza F: The district health information system (DHIS) for FY 2014/2015. 2015.
25.
Bennett S, Woods T, Liyanage WM, Smith DL. A simplified general method for cluster-sample surveys of health in developing countries. World Health Stat Q. 1991;44(3):98–106.PubMed
26.
Turner AG. Sampling strategies. United Nations Statistics Division: Handbook on designing of household sample surveys Geneva; 2003.
27.
Arold F, Bostoen K, Croft T, David P, Frazier C, Henderson M, Hueb J, Kleinau E, Kolsky P, Luyendijk R, Mugai R, Wardlaw T. Core questions on drinking-water and sanitation for household surveys. Geneva, Switzerland: World Health Organization, United Nations Children’s Fund; 2006, 24. WHO, UNICEF: 2006.
28.
Foreyt WJ. Diagnostic parasitology. Vet Clin N Am Small Anim Pract. 1989;19(5):979–1000.CrossRef
29.
Suwansaksri J, Nithiuthai S, Wiwanitkit V, Soogarun S, Palatho P. The formol-ether concentration technique for intestinal parasites: comparing 0.1 N sodium hydroxide with normal saline preparations. Southeast Asian J Trop Med Public Health. 2003;33:97–8.
30.
Alemu G, Mama M. Intestinal helminth co-infection and associated factors among tuberculosis patients in Arba Minch, Ethiopia. BMC Infect Dis. 2017;17(1):68.CrossRefPubMedPubMedCentral
31.
Alelign T, Degarege A, Erko B. Soil-transmitted helminth infections and associated risk factors among schoolchildren in Durbete town. Northwestern Ethiopia. Journal of parasitology research. 2015;2015
32.
Mayega RW, Guwatudde D, Makumbi F, Nakwagala FN, Peterson S, Tomson G, Ostenson C-G. Diabetes and pre-diabetes among persons aged 35 to 60 years in eastern Uganda: prevalence and associated factors. PLoS One. 2013;8(8):e72554.CrossRefPubMedPubMedCentral
33.
UBOS: Uganda Bureau of Statistics, Macro International Inc. (2007) Uganda Demographic and Health Survey 2006. In:, Calverton M, USA: UBOS and Macro. UBOS and Macro International Inc.. pp. 19–20. 2006.
34.
Filmer D, Pritchett LH. Estimating wealth effects without expenditure data—or tears: an application to educational enrollments in states of India. Demography. 2001;38(1):115–32.PubMed
35.
Mayega RW, Makumbi F, Rutebemberwa E, Peterson S, Östenson C-G, Tomson G, Guwatudde D. Modifiable socio-behavioural factors associated with overweight and hypertension among persons aged 35 to 60 years in eastern Uganda. PLoS One. 2012;7(10):e47632.CrossRefPubMedPubMedCentral
36.
Campbell SJ, Savage GB, Gray DJ, Atkinson J-AM, Magalhaes RJS, Nery SV, McCarthy JS, Velleman Y, Wicken JH, Traub RJ. Water, sanitation, and hygiene (WASH): a critical component for sustainable soil-transmitted helminth and schistosomiasis control. PLoS Negl Trop Dis. 2014;8(4):e2651.CrossRefPubMedPubMedCentral
37.
Charles B, Babirye J, Atuyambe L: The level and determinants of male partner involvement in routine child immunization Care in Hoima District Uganda: a cross-sectional study. 2014.
38.
Montresor A, Crompton D, Hall A, Bundy D, Savioli L. Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. Geneva: World Health Organization; 1998. p. 1–49.
39.
Fusi-Ngwa C, Besong E, Pone JW, Mbida M. A cross-sectional study of intestinal parasitic infections in children in Ghettoed, diverse and affluent communities in Dschang, west region, Cameroon. Open Access Library J. 2014;1(09):1.
40.
Degarege A, Erko B. Prevalence of intestinal parasitic infections among children under five years of age with emphasis on Schistosoma mansoni in Wonji Shoa sugar estate, Ethiopia. PloS one. 2014;9(10):e109793.CrossRefPubMedPubMedCentral
41.
Nyantekyi LA, Legesse M, Belay M, Tadesse K, Manaye K, Macias C, Erko B. Intestinal parasitic infections among under-five children and maternal awareness about the infections in Shesha Kekele, Wondo Genet, Southern Ethiopia. Ethiop J Health Dev. 2010;24(3):185–90
42.
Kirwan P, Asaolu SO, Molloy SF, Abiona TC, Jackson AL, Holland CV. Patterns of soil-transmitted helminth infection and impact of four-monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial. BMC Infect Dis. 2009;9(1):1.CrossRef
43.
Kabatereine NB, Standley CJ, Sousa-Figueiredo JC, Fleming FM, Stothard JR, Talisuna A, Fenwick A. Integrated prevalence mapping of schistosomiasis, soil-transmitted helminthiasis and malaria in lakeside and island communities in Lake Victoria, Uganda. Parasit Vectors. 2011;4:232.CrossRefPubMedPubMedCentral
44.
Gungoren B, Latipov R, Regallet G, Musabaev E. Effect of hygiene promotion on the risk of reinfection rate of intestinal parasites in children in rural Uzbekistan. Trans R Soc Trop Med Hyg. 2007;101(6):564–9.CrossRefPubMed
45.
Echazú A, Bonanno D, Juarez M, Cajal SP, Heredia V, Caropresi S, Cimino RO, Caro N, Vargas PA, Paredes G. Effect of poor access to water and sanitation as risk factors for soil-transmitted helminth infection: selectiveness by the infective route. PLoS Negl Trop Dis. 2015;9(9):e0004111.CrossRefPubMedPubMedCentral
46.
Nasr NA, Al-Mekhlafi HM, Ahmed A, Roslan MA, Bulgiba A: Towards an effective control programme of soil-transmitted helminth infections among Orang Asli in rural Malaysia. Part 2: Knowledge, attitude, and practices. Parasit Vectors 2013, 6:28.
47.
Ngui R, Lim YAL, Kin LC, Chuen CS, Jaffar S. Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West Malaysia. PLoS Negl Trop Dis. 2012;6(3):e1550.CrossRefPubMedPubMedCentral
48.
Standley CJ, Adriko M, Alinaitwe M, Kazibwe F, Kabatereine NB, Stothard JR. Intestinal schistosomiasis and soil-transmitted helminthiasis in Ugandan schoolchildren: a rapid mapping assessment. Geospat Health. 2009;4(1):39–53.CrossRefPubMed
49.
Wang X, Zhang L, Luo R, Wang G, Chen Y, Medina A, Eggleston K, Rozelle S, Smith DS. Soil-transmitted helminth infections and correlated risk factors in preschool and school-aged children in rural Southwest China. PLoS One. 2012;7(9):e45939.CrossRefPubMedPubMedCentral
50.
Albonico M, Allen H, Chitsulo L, Engels D, Gabrielli A-F, Savioli L. Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Negl Trop Dis. 2008;2(3):e126.CrossRefPubMedPubMedCentral
51.
Holland C, Asaolu S, Crompton D, Whitehead R, Coombs I. Targeted anthelminthic treatment of school children: effect of frequency of application on the intensity of Ascaris lumbricoides infection in children from rural Nigerian villages. Parasitology. 1996;113(01):87–95.CrossRefPubMed
52.
Saathoff E, Olsen A, Kvalsvig JD, Geissler PW. Geophagy and its association with geohelminth infection in rural schoolchildren from northern KwaZulu-Natal, South Africa. Trans R Soc Trop Med Hyg. 2002;96(5):485–90.CrossRefPubMed
53.
Menzies SK, Rodriguez A, Chico M, Sandoval C, Broncano N, Guadalupe I, Cooper PJ. Risk factors for soil-transmitted helminth infections during the first 3 years of life in the tropics; findings from a birth cohort. PLoS Negl Trop Dis. 2014;8(2):e2718.CrossRefPubMedPubMedCentral
54.
Verhagen LM, Incani RN, Franco CR, Ugarte A, Cadenas Y, Ruiz CIS, Hermans PW, Hoek D, Ponce MC, de Waard JH. High malnutrition rate in Venezuelan Yanomami compared to Warao Amerindians and creoles: significant associations with intestinal parasites and anemia. PLoS One. 2013;8(10):e77581.CrossRefPubMedPubMedCentral
55.
Abu-Madi MA, Behnke JM, Doiphode SH. Changing trends in intestinal parasitic infections among long-term-residents and settled immigrants in Qatar. Parasit Vectors. 2010;3(1):1–13.CrossRef
56.
Raso G, Matthys B, N'goran E, Tanner M, Vounatsou P, Utzinger J. Spatial risk prediction and mapping of Schistosoma mansoni infections among schoolchildren living in western Côte d'Ivoire. Parasitology. 2005;131(01):97–108.CrossRefPubMed
57.
Ziegelbauer K, Speich B, Mäusezahl D, Bos R, Keiser J, Utzinger J. Effect of sanitation on soil-transmitted helminth infection: systematic review and meta-analysis. PLoS Med. 2012;9(1):e1001162.CrossRefPubMedPubMedCentral
58.
Freeman MC, Ogden S, Jacobson J, Abbott D, Addiss DG, Amnie AG, Beckwith C, Cairncross S, Callejas R, Colford JM Jr. Integration of water, sanitation, and hygiene for the prevention and control of neglected tropical diseases: a rationale for inter-sectoral collaboration. PLoS Negl Trop Dis. 2013;7(9):e2439.CrossRefPubMedPubMedCentral
59.
Truscott J, Turner H, Anderson R. What impact will the achievement of the current World Health Organisation targets for anthelmintic treatment coverage in children have on the intensity of soil transmitted helminth infections? Parasit Vectors. 2015;8(1):1–12.CrossRef
Metadata
Title
Prevalence, intensity and factors associated with soil-transmitted helminths infections among preschool-age children in Hoima district, rural western Uganda
Authors
Silvestro Ojja
Stevens Kisaka
Michael Ediau
Doreen Tuhebwe
Angela N. Kisakye
Abdullah A. Halage
Richard K. Mugambe
Joan N. Mutyoba
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2018
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-018-3289-0

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