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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2018

Open Access 01-12-2018 | Research article

High prevalence of HIV-1 transmitted drug resistance among therapy-naïve Burmese entering travelers at Dehong ports in Yunnan, China

Authors: Qicai Xuan, Shuwen Liang, Weihong Qin, Shuting Yang, A-mei Zhang, Ting Zhao, Hui Su, Zhiqing Xia, Binghui Wang, Xueshan Xia

Published in: BMC Infectious Diseases | Issue 1/2018

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Abstract

Background

The overall success of Human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy (ART) was heavily challenged upon the occurrence of drug resistance. Dehong Prefecture witnessed not only the first report of HIV-1 infection but also the experimental adoption of antiviral treatment in China. The transmission and epidemic of HIV-1 in Dehong is impacted by cross-border activities. The characteristics of HIV-1 drug resistance among therapy-naïve Burmese entering travelers in Yunnan and their speculated origin are still not clarified.

Methods

Two hundred ninety-eight HIV-1 infected Burmese entering travelers at Dehong ports were recruited between 2003 and 2012. The partial HIV-1 pol gene fragments were amplified and sequenced for the analysis of drug-resistance mutations (DRMs). Phylogenetic analysis on gag-pol gene was conducted to elucidate phylogenetic and evolutionary characteristics of these drug resistant strains.

Results

It was figured out that the occurrence ratio of HIV-1 drug resistance among HIV-1 infected entering travelers from Myanmar was up to 12.8%. The resistant mutations covered several types, including one type of PI mutations (L33F), six types of NRTI mutations and seven types of NNRTI. Close genetic relationship was observed in the phylogenetic analysis on gag-pol gene among the drug resistant strains respectively from Dehong, other Yunnan areas, neighboring provinces (Guangxi) and neighboring countries (Thailand and Myanmar).

Conclusions

The findings in this study revealed that HIV drug resistant locus is spreading from the population who is receiving drug-resistance treatment to the new infectors, which indicates the urgency of surveillance work on drug resistance among the migrant population with high risks of HIV infection.
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Literature
1.
Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493–505.CrossRefPubMedPubMedCentral
2.
Attia S, Egger M, Müller M, Zwahlen M, Low N. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS. 2009;23:1397–404.CrossRefPubMed
3.
Porco TC, Martin JN, Page-Shafer KA, Cheng A, Charlebois E, Grant RM, et al. Decline in HIV infectivity following the introduction of highly active antiretroviral therapy. AIDS. 2004;18:81–8.CrossRefPubMedPubMedCentral
4.
Pham QD, Wilson DP, Law MG, Kelleher AD, Zhang L. Global burden of transmitted HIV drug resistance and HIV-exposure categories: a systematic review and meta-analysis. AIDS. 2014;28(18):2751–62.CrossRefPubMed
5.
WHO HIV/AIDS Programme. The HIV drug resistance report-2012.
6.
Sun X, Nan J, Guo Q. AIDS and HIV infection in China. AIDS. 1994;8(Suppl 2):S55–9.PubMed
7.
Wang B, Liang Y, Wang Y, Feng Y, Li Y, et al. HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012. J Med Virol. 2017;89(6):1112–5.CrossRefPubMed
8.
Wang B, Liang Y, Feng Y, Li Y, Wang Y, et al. Prevalence of human immunodeficiency virus 1 infection in the last decade among entry travelers in Yunnan Province, China. BMC Public Health. 2015;15:362.CrossRefPubMedPubMedCentral
9.
Shan D, Sun J, Khoshnood K, Fu J, Duan S, Jiang C, et al. The impact of comprehensive prevention of mother-to-child HIV transmission in Dehong prefecture, Yunnan province, 2005-2010: a hard-hit area by HIV in southern China. Int J STD AIDS. 2014;25(4):253–60.CrossRefPubMed
10.
Zheng XW, Zhang JP, Tian CQ, Cheng HH, Yang XZ, Duan S, et al. Cohort study of HIV infection among drug users in Ruili, Longchuan and Luxi of Yunnan Province, China`. Biomed Environ Sci. 1993;6(4):348–51.PubMed
11.
Zheng X, Tian C, Choi KH, Zhang J, Cheng H, Yang X, et al. Injecting drug use and HIV infection in Southwest China. AIDS. 1994;8(8):1141–7.CrossRefPubMed
12.
Wang Y, Liang Y, Feng Y, Wang B, Li Y, et al. HIV-1 prevalence and subtype/recombinant distribution among travelers entering China from Vietnam at the HeKou port in the Yunnan province, China, between 2003 and 2012. J Med Virol. 2015;87(9):1500–9.CrossRefPubMed
13.
Aiyar A. The use of CLUSTAL W and CLUSTAL X for multiple sequence alignment. Methods Mol Biol. 2000;132:221–41.PubMed
14.
Bennett DE, Camacho RJ, Otelea D, Kuritzkes DR, Fleury H, Kiuchi M, et al. Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. PLoS One. 2009;4(3):e4724.CrossRefPubMedPubMedCentral
15.
Shafer RW, Rhee SY, Pillay D, Miller V, Sandstrom P, Schapiro JM, et al. HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance. AIDS. 2007;21:215–23.CrossRefPubMedPubMedCentral
16.
Kumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol. 2016;33(7):1870–1874.CrossRefPubMed
17.
Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, et al. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol. 1999;73:152–60.PubMedPubMedCentral
18.
Su YZ, Ma YL, Jia MH, He X, Yang L, Cheng CL, et al. Update on diversity and distribution of HIV-1 subtypes in Yunnan province. Epidemiol Infect. 2013;141(11):2418–27.CrossRefPubMed
19.
Li L, Sun G, Liang S, Li J, Li T, Wang Z, et al. Different distribution of HIV-1 subtype and drug resistance were found among treatment naïve individuals in Henan, Guangxi, and Yunnan province of China. PLoS One. 2013;8(10):e75777.CrossRefPubMedPubMedCentral
20.
Pham HV, Ishizaki A, Nguyen CH, Saina MC, Hoang HT, Tran VT, et al. Change in the prevalence of HIV-1 and the rate of transmitted drug-resistant HIV-1 in Haiphong, northern Vietnam. AIDS Res Hum Retrovir. 2015;31(7):757–9.CrossRefPubMed
21.
Frentz D, Boucher CA, van de Vijver DA. Temporal changes in the epidemiology of transmission of drug-resistant HIV-1 across the world. AIDS Rev. 2012;14(1):17–27.PubMed
22.
Li H, Zhong M, Guo W, Zhuang D, Li L, Liu Y, et al. Prevalence and mutation patterns of HIV drug resistance from 2010 to 2011 among ART-failure individuals in the Yunnan Province, China. PLoS One. 2013;8(8):e72630.CrossRefPubMedPubMedCentral
23.
Li L, Sun B, Zeng H, Sun Z, Sun G, Yang R. Relatively high prevalence of drug resistance among antiretroviral-naive patients from Henan, Central China. AIDS Res Hum Retrovir. 2014;30(2):160–4.CrossRefPubMedPubMedCentral
24.
Liu J, Jiao Y, Li L, Zeng Z, Li C, Li S, et al. Research on the mutations of relevant drug resistance gene sites in newly confirmed HIV-1 infectors. Chinese J Health Lab Technol. 2016;5:753–5. (in Chinese)
25.
Chen M, Ma Y, Su Y, Yang L, Zhang R, et al. HIV-1 genetic characteristics and transmitted drug resistance among men who have sex with men in Kunming, China. PLoS One. 2014;9(1):e87033.CrossRefPubMedPubMedCentral
26.
Chen M, Wang J, Xing H, Ma Y, Yao S, Chen H, et al. Study on the threshold of HIV-1 drug resistance in Dehong prefecture of Yunnan province in 2014. Zhonghua Liu Xing Bing Xue Za Zhi. 2014;35(8):909–12. (in Chinese)PubMed
27.
Sanguansittianant S, Nooroon N, Phaengchomduan P, Ammaranond P. Trends in prevalence of HIV-1 drug resistance in Thailand 2009-2010. J Clin Lab Anal. 2013;27(5):346–53.CrossRefPubMed
28.
Barth RE, van der Loeff MF, Schuurman R, Hoepelman AI, Wensing AM. Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review. Lancet Infect Dis. 2010;10(3):155–66.CrossRefPubMed
29.
Hosseinipour MC, Gupta RK, Van Zyl G, Eron JJ, Nachega JB. Emergence of HIV drug resistance during frst- and second-line antiretroviral therapy in resource-limited settings. J Infect Dis. 2013;207(Suppl 2):S49–56.CrossRefPubMedPubMedCentral
30.
Jiao Y, Li S, Li Z, Zhang Z, Zhao J, Li L, et al. HIV-1 transmitted drug resistance-associated mutations and mutation co-variation in HIV-1 treatment-naïve MSM from 2011 to 2013 in Beijing, China. BMC Infect Dis. 2014;14:689.CrossRefPubMedPubMedCentral
31.
Lu X, Zhao H, Zhang Y, Wang W, Zhao C, Li Y, et al. HIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, China. AIDS Res Ther. 2017;14(1):4.CrossRefPubMedPubMedCentral
32.
Sui H, Gui T, Jia L, Guo W, Han J, Liu Y, et al. Different frequencies of drug resistance mutations among HIV-1 subtypes circulating in China: a comprehensive study. PLoS One. 2014;9(3):e91803.CrossRefPubMedPubMedCentral
Metadata
Title
High prevalence of HIV-1 transmitted drug resistance among therapy-naïve Burmese entering travelers at Dehong ports in Yunnan, China
Authors
Qicai Xuan
Shuwen Liang
Weihong Qin
Shuting Yang
A-mei Zhang
Ting Zhao
Hui Su
Zhiqing Xia
Binghui Wang
Xueshan Xia
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2018
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-018-3130-9

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