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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2018

Open Access 01-12-2018 | Research article

Characterization of Salmonella enterica from invasive bloodstream infections and water sources in rural Ghana

Authors: Denise Dekker, Ralf Krumkamp, Daniel Eibach, Nimako Sarpong, Kennedy Gyau Boahen, Michael Frimpong, Elina Fechtner, Sven Poppert, Ralf Matthias Hagen, Norbert Georg Schwarz, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, Justin Im, Florian Marks, Hagen Frickmann, Jürgen May

Published in: BMC Infectious Diseases | Issue 1/2018

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Abstract

Background

Non-typhoidal Salmonella (NTS) cause the majority of bloodstream infections in Ghana, however the mode of transmission and source of invasive NTS in Africa are poorly understood. This study compares NTS from water sources and invasive bloodstream infections in rural Ghana.

Methods

Blood from hospitalised, febrile children and samples from drinking water sources were analysed for Salmonella spp. Strains were serotyped to trace possible epidemiological links between human and water-derived isolates.. Antibiotic susceptibility testing was performed,

Results

In 2720 blood culture samples, 165 (6%) NTS were isolated. S. Typhimurium (70%) was the most common serovar followed by S. Enteritidis (8%) and S. Dublin (8%). Multidrug resistance (MDR) was found in 95 (58%) NTS isolates, including five S. Enteritidis. One S. Typhimurium showed reduced fluroquinolone susceptibility. In 511 water samples, 19 (4%) tested positive for S. enterica with two isolates being resistant to ampicillin and one isolate being resistant to cotrimoxazole. Serovars from water samples were not encountered in any of the clinical specimens.

Conclusion

Water analyses demonstrated that common drinking water sources were contaminated with S. enterica posing a potential risk for transmission. However, a link between S. enterica from water sources and patients could not be established, questioning the ability of water-derived serovars to cause invasive bloodstream infections.
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Metadata
Title
Characterization of Salmonella enterica from invasive bloodstream infections and water sources in rural Ghana
Authors
Denise Dekker
Ralf Krumkamp
Daniel Eibach
Nimako Sarpong
Kennedy Gyau Boahen
Michael Frimpong
Elina Fechtner
Sven Poppert
Ralf Matthias Hagen
Norbert Georg Schwarz
Yaw Adu-Sarkodie
Ellis Owusu-Dabo
Justin Im
Florian Marks
Hagen Frickmann
Jürgen May
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2018
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-018-2957-4

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