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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2017

Open Access 01-12-2017 | Case report

Spondylodiscitis in a healthy 12-year-old girl with Extraintestinal pathogenic Escherichia coli (ExPEC) bacteraemia

Authors: J. Gaschignard, G. Geslain, C. Mallet, M. Lorrot, N. Blot, M. Alison, S. Bonacorsi

Published in: BMC Infectious Diseases | Issue 1/2017

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Abstract

Background

Escherichia coli (E. coli) is rarely implicated in bone or joint infections in children.

Case presentation

We discuss the case of a healthy 12-year-old girl with an E. coli bacteraemia and a T11-T12 spondylodiscitis revealed by magnetic resonance imaging. The strain harboured serogroup O1:K1 and virulence factors common to highly virulent extra intestinal pathogenic E. coli (ExPEC). Immunological work-up was normal.

Conclusion

The identification of E. coli in a spondylodiscitis should lead to the search for immunosuppression of the host and virulence factors of the strain, particularly those of ExPEC.
Literature
1.
2.
3.
Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum. 2009;39:10–7.CrossRefPubMed
4.
Kang S-J, Jang H-C, Jung S-I, Choe PG, Park WB, Kim C-J, et al. Clinical characteristics and risk factors of pyogenic spondylitis caused by gram-negative bacteria. PLoS One. 2015;10:e0127126.CrossRefPubMedPubMedCentral
5.
Bidet P, Mahjoub-Messai F, Blanco J, Blanco J, Dehem M, Aujard Y, et al. Combined multilocus sequence typing and O serogrouping distinguishes Escherichia coli subtypes associated with infant urosepsis and/or meningitis. J Infect dis. 2007;196:297–303.CrossRefPubMed
6.
Peigne C, Bidet P, Mahjoub-Messai F, Plainvert C, Barbe V, Médigue C, et al. The plasmid of Escherichia coli strain S88 (O45:K1:H7) that causes neonatal meningitis is closely related to avian pathogenic E. coli plasmids and is associated with high-level bacteremia in a neonatal rat meningitis model. Infect Immun. 2009;77:2272–84.CrossRefPubMedPubMedCentral
7.
Johnson JR, Johnston B, Kuskowski MA, Nougayrede J-P, Oswald E. Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island. J Clin Microbiol. 2008;46:3906–11.CrossRefPubMedPubMedCentral
8.
Russo TA, Johnson JR. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect Inst Pasteur. 2003;5:449–56.CrossRef
9.
de Kraker MEA, Jarlier V, Monen JCM, Heuer OE, van de Sande N, Grundmann H. The changing epidemiology of bacteraemias in Europe: trends from the European antimicrobial resistance surveillance system. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect dis. 2013;19:860–8.
10.
Picard B, Garcia JS, Gouriou S, Duriez P, Brahimi N, Bingen E, et al. The link between phylogeny and virulence in Escherichia coli extraintestinal infection. Infect Immun. 1999;67:546–53.PubMedPubMedCentral
11.
Burdet C, Clermont O, Bonacorsi S, Laouénan C, Bingen E, Aujard Y, Mentré F, Lefort A, Denamur E, COLIBAFI Group. Escherichia coli Bacteremia in children: age and portal of entry are the main predictors of severity. Pediatr Infect dis J. 2014;33:872–9.CrossRef
12.
Lemaître C, Mahjoub-Messai F, Dupont D, Caro V, Diancourt L, Bingen E, et al. A conserved virulence plasmidic region contributes to the virulence of the multiresistant Escherichia coli meningitis strain S286 belonging to phylogenetic group C. PLoS One. 2013;8:e74423.CrossRefPubMedPubMedCentral
13.
Leying H, Suerbaum S, Kroll HP, Stahl D, Opferkuch W. The capsular polysaccharide is a major determinant of serum resistance in K-1-positive blood culture isolates of Escherichia coli. Infect Immun. 1990;58:222–7.PubMedPubMedCentral
14.
Sarkar S, Ulett GC, Totsika M, Phan M-D, Schembri MA. Role of capsule and O antigen in the virulence of uropathogenic Escherichia coli. PLoS One. 2014;9:e94786.CrossRefPubMedPubMedCentral
15.
Crémet L, Broquet A, Brulin B, Jacqueline C, Dauvergne S, Brion R, Asehnoune K, Corvec S, Heymann D, Caroff N. 2015. Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells. Pathog dis 73:ftv065.
Metadata
Title
Spondylodiscitis in a healthy 12-year-old girl with Extraintestinal pathogenic Escherichia coli (ExPEC) bacteraemia
Authors
J. Gaschignard
G. Geslain
C. Mallet
M. Lorrot
N. Blot
M. Alison
S. Bonacorsi
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2017
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-017-2486-6

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