Skip to main content
Top
Published in: BMC Infectious Diseases 1/2016

Open Access 01-12-2016 | Research article

Regional variation in antibiotic prescribing among medicare part D enrollees, 2013

Authors: Andre Arizpe, Kelly R. Reveles, Samuel L. Aitken

Published in: BMC Infectious Diseases | Issue 1/2016

Login to get access

Abstract

Background

Antibiotics are among the most widely prescribed medications. The geographic variation in antibiotic prescribing patterns and associated costs among Medicare Part D recipients have not been described. The purpose of this study was to assess the regional variation in antibiotic prescriptions and costs among Medicare Part D enrollees in 2013.

Methods

Retrospective cohort review of all Medicare Part D enrollees in 2013, using the Medicare Provider Utilization and Payment Data: Part D Prescriber Public Use File. All original or refill prescription claims for antibiotics as listed in the Part D Prescriber Public Use File were included. Our primary outcomes were total antibiotic claims and antibiotic cost per Medicare Part D Enrollee. Data were analyzed descriptively by state and by geographic region as defined by the United States Census Bureau. Antibiotic claims were described overall and by antibiotic class.

Results

Over 54 million outpatient antibiotic claims were filed for Part D enrollees in 2013, representing more than $1.5 billion in total antibiotic expenditures. Antibiotic use was highest in the South (1,623 claims/1,000 enrollees), followed by the Midwest (1,401 claims/1,000 enrollees), Northeast (1,366 claims/1,000 enrollees), and West (1,292 claims/1,000 enrollees). Average antibiotic costs per enrollee in each region were as follows: South $46.58, Northeast $43.70, Midwest $40.54, and West $36.42. Fluoroquinolones were the most commonly prescribed class overall (12.2 million claims).

Conclusions

Antibiotic use among elderly Medicare enrollees in the United States was highest in the South region. Fluoroquinolones were the most common antibiotics used in all regions. These patterns could be utilized in the development of targeted antimicrobial stewardship efforts.
Appendix
Available only for authorised users
Literature
1.
go back to reference Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards Jr J. Infectious diseases society of a: the epidemic of antibiotic-resistant infections: a call to action for the medical community from the infectious diseases society of America. Clin Infect Dis. 2008;46(2):155–64.CrossRefPubMed Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards Jr J. Infectious diseases society of a: the epidemic of antibiotic-resistant infections: a call to action for the medical community from the infectious diseases society of America. Clin Infect Dis. 2008;46(2):155–64.CrossRefPubMed
3.
go back to reference Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ. 2010;340:c2096.CrossRefPubMed Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ. 2010;340:c2096.CrossRefPubMed
4.
go back to reference Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File Jr TM, Finkelstein JA, Gerber JS, Hyun DY, Linder JA, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA. 2016;315(17):1864–73.CrossRefPubMed Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File Jr TM, Finkelstein JA, Gerber JS, Hyun DY, Linder JA, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA. 2016;315(17):1864–73.CrossRefPubMed
5.
go back to reference Lee GC, Reveles KR, Attridge RT, Lawson KA, Mansi IA, Lewis JS II, Frei CR. Outpatient antibiotic prescribing in the United States: 2000 to 2010. BMC Medicine. 2014;12(96). doi:10.1186/1741-7015-12-96. Lee GC, Reveles KR, Attridge RT, Lawson KA, Mansi IA, Lewis JS II, Frei CR. Outpatient antibiotic prescribing in the United States: 2000 to 2010. BMC Medicine. 2014;12(96). doi:10.​1186/​1741-7015-12-96.
6.
go back to reference Hicks LA, Bartoces MG, Roberts RM, Suda KJ, Hunkler RJ, Taylor Jr TH, Schrag SJ. US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. Clin Infect Dis. 2015;60(9):1308–16.PubMed Hicks LA, Bartoces MG, Roberts RM, Suda KJ, Hunkler RJ, Taylor Jr TH, Schrag SJ. US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. Clin Infect Dis. 2015;60(9):1308–16.PubMed
7.
go back to reference Zhang Y, Steinman MA, Kaplan CM. Geographic variation in outpatient antibiotic prescribing among older adults. Arch Intern Med. 2012;172(19):1465–71.CrossRefPubMedPubMedCentral Zhang Y, Steinman MA, Kaplan CM. Geographic variation in outpatient antibiotic prescribing among older adults. Arch Intern Med. 2012;172(19):1465–71.CrossRefPubMedPubMedCentral
11.
go back to reference Steinman MA, Landefeld CS, Gonzales R. Predictors of broad-spectrum antibiotic prescribing for acute respiratory tract infections in adult primary care. JAMA. 2003;289(6):719–25.CrossRefPubMed Steinman MA, Landefeld CS, Gonzales R. Predictors of broad-spectrum antibiotic prescribing for acute respiratory tract infections in adult primary care. JAMA. 2003;289(6):719–25.CrossRefPubMed
13.
go back to reference Alsan M, Morden NE, Gottlieb JD, Zhou W, Skinner J. Antibiotic use in cold and Flu season and prescribing quality: a retrospective cohort study. Med Care. 2015;53(12):1066–71.CrossRefPubMedPubMedCentral Alsan M, Morden NE, Gottlieb JD, Zhou W, Skinner J. Antibiotic use in cold and Flu season and prescribing quality: a retrospective cohort study. Med Care. 2015;53(12):1066–71.CrossRefPubMedPubMedCentral
14.
go back to reference Faulkner CM, Cox HL, Williamson JC. Unique aspects of antimicrobial use in older adults. Clin Infect Dis. 2005;40(7):997–1004.CrossRefPubMed Faulkner CM, Cox HL, Williamson JC. Unique aspects of antimicrobial use in older adults. Clin Infect Dis. 2005;40(7):997–1004.CrossRefPubMed
15.
go back to reference Houston MS, Silverstein MD, Suman VJ. Risk factors for 30-day mortality in elderly patients with lower respiratory tract infection. Community-based study Arch Intern Med. 1997;157(19):2190–5.CrossRefPubMed Houston MS, Silverstein MD, Suman VJ. Risk factors for 30-day mortality in elderly patients with lower respiratory tract infection. Community-based study Arch Intern Med. 1997;157(19):2190–5.CrossRefPubMed
16.
go back to reference Owens Jr RC, Ambrose PG. Antimicrobial safety: focus on fluoroquinolones. Clin Infect Dis. 2005;41 Suppl 2:S144–157.CrossRefPubMed Owens Jr RC, Ambrose PG. Antimicrobial safety: focus on fluoroquinolones. Clin Infect Dis. 2005;41 Suppl 2:S144–157.CrossRefPubMed
17.
go back to reference Stahlmann R, Lode H. Safety considerations of fluoroquinolones in the elderly: an update. Drugs Aging. 2010;27(3):193–209.CrossRefPubMed Stahlmann R, Lode H. Safety considerations of fluoroquinolones in the elderly: an update. Drugs Aging. 2010;27(3):193–209.CrossRefPubMed
18.
go back to reference MacDougall C, Powell JP, Johnson CK, Edmond MB, Polk RE. Hospital and community fluoroquinolone use and resistance in Staphylococcus aureus and Escherichia coli in 17 US hospitals. Clin Infect Dis. 2005;41(4):435–40.CrossRefPubMed MacDougall C, Powell JP, Johnson CK, Edmond MB, Polk RE. Hospital and community fluoroquinolone use and resistance in Staphylococcus aureus and Escherichia coli in 17 US hospitals. Clin Infect Dis. 2005;41(4):435–40.CrossRefPubMed
19.
go back to reference Lopez-Dupla M, Martinez JA, Vidal F, Almela M, Soriano A, Marco F, Lopez J, Olona M, Mensa J. Previous ciprofloxacin exposure is associated with resistance to beta-lactam antibiotics in subsequent Pseudomonas aeruginosa bacteremic isolates. Am J Infect Control. 2009;37(9):753–8.CrossRefPubMed Lopez-Dupla M, Martinez JA, Vidal F, Almela M, Soriano A, Marco F, Lopez J, Olona M, Mensa J. Previous ciprofloxacin exposure is associated with resistance to beta-lactam antibiotics in subsequent Pseudomonas aeruginosa bacteremic isolates. Am J Infect Control. 2009;37(9):753–8.CrossRefPubMed
20.
go back to reference FDA Drug Safety Communication. FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together. In: U.S. Food and drug administration. 2016. FDA Drug Safety Communication. FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together. In: U.S. Food and drug administration. 2016.
22.
go back to reference Mortensen EM, Halm EA, Pugh MJ, Copeland LA, Metersky M, Fine MJ, Johnson CS, Alvarez CA, Frei CR, Good C, et al. Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia. JAMA. 2014;311(21):2199–208.CrossRefPubMedPubMedCentral Mortensen EM, Halm EA, Pugh MJ, Copeland LA, Metersky M, Fine MJ, Johnson CS, Alvarez CA, Frei CR, Good C, et al. Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia. JAMA. 2014;311(21):2199–208.CrossRefPubMedPubMedCentral
23.
go back to reference Schroeck JL, Ruh CA, Sellick Jr JA, Ott MC, Mattappallil A, Mergenhagen KA. Factors associated with antibiotic misuse in outpatient treatment for upper respiratory tract infections. Antimicrob Agents Chemother. 2015;59(7):3848–52.CrossRefPubMedPubMedCentral Schroeck JL, Ruh CA, Sellick Jr JA, Ott MC, Mattappallil A, Mergenhagen KA. Factors associated with antibiotic misuse in outpatient treatment for upper respiratory tract infections. Antimicrob Agents Chemother. 2015;59(7):3848–52.CrossRefPubMedPubMedCentral
24.
go back to reference Alpern JD, Stauffer WM, Kesselheim AS. High-cost generic drugs--implications for patients and policymakers. N Engl J Med. 2014;371(20):1859–62.CrossRefPubMed Alpern JD, Stauffer WM, Kesselheim AS. High-cost generic drugs--implications for patients and policymakers. N Engl J Med. 2014;371(20):1859–62.CrossRefPubMed
25.
go back to reference Drekonja DM, Filice GA, Greer N, Olson A, MacDonald R, Rutks I, Wilt TJ. Antimicrobial stewardship in outpatient settings: a systematic review. Infect Control Hosp Epidemiol. 2015;36(2):142–52.CrossRefPubMed Drekonja DM, Filice GA, Greer N, Olson A, MacDonald R, Rutks I, Wilt TJ. Antimicrobial stewardship in outpatient settings: a systematic review. Infect Control Hosp Epidemiol. 2015;36(2):142–52.CrossRefPubMed
Metadata
Title
Regional variation in antibiotic prescribing among medicare part D enrollees, 2013
Authors
Andre Arizpe
Kelly R. Reveles
Samuel L. Aitken
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2016
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-016-2091-0

Other articles of this Issue 1/2016

BMC Infectious Diseases 1/2016 Go to the issue