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BMC Infectious Diseases

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Open Access 01-12-2016 | Research article

Serum neutrophil gelatinase-associated lipocalin and resistin are associated with dengue infection in adults

Authors: Kuan-Ting Liu, Yao-Hua Liu, Chun-Yu Lin, Ming-Ju Tsai, Ya-Ling Hsu, Meng-Chi Yen, Po-Lin Kuo

Published in: BMC Infectious Diseases | Issue 1/2016

Abstract

Background

Dengue is a major health problem in tropical areas, including Taiwan. Dengue virus infection affects various types of cells and results in elevation of serum inflammatory molecules. Because these molecules may be associated with dengue virus infection, the aim of this study was to identify novel molecules in febrile patients with dengue infection. In addition, we determined whether these molecules were correlated with the count of leukocytes and platelets.

Methods

Febrile adults (Age >18 years old) who presented to the emergency department and were confirmed dengue virus infection were enrolled in this study. Serum from dengue patients and healthy controls was collected and serum level of sepsis-associated inflammatory molecules was measured by Luminex assay.

Results

Elevated level of macrophage migration inhibitory factor, soluble vascular cell adhesion molecule-1, sFasL, resistin and interferon-γ were detected in patients’ serum. Higher levels of neutrophil gelatinase-associated lipocalin (NGAL) and resistin were detected in dengue patients with normal leukocyte count and all dengue patients, respectively. Furthermore, the serum level of NGAL, but not resistin, was correlated with cell count in dengue patients.

Conclusion

Our results revealed that resistin and NGAL are novel dengue-associated molecules. These results may help elucidate the regulatory mechanisms of anti-dengue immune responses.

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Title: Serum neutrophil gelatinase-associated lipocalin and resistin are associated with dengue infection in adults
Authors: Kuan-Ting Liu
Yao-Hua Liu
Chun-Yu Lin
Ming-Ju Tsai
Ya-Ling Hsu
Meng-Chi Yen
Po-Lin Kuo
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Infectious Diseases / Issue 1/2016
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-016-1759-9

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