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BMC Hematology

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Open Access 01-12-2015 | Case report

Case-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib

Authors: Róbert Pálmason, Ola Lindén, Johan Richter

Published in: BMC Hematology | Issue 1/2015

Abstract

Background

Ruxolitinib, a novel inhibitor of Janus kinases 1 and 2, was recently approved for the treatment of myelofibrosis but, recently, attention has been drawn to potential side effects and especially opportunistic infections and virus reactivations. EBV reactivation has not previously been reported to occur in association with Ruxolitinib.

Case presentation

We report a case of a 57 year old female with post-polycythemic myelofibrosis who was treated with Ruxolitinib. Approximately 9 weeks later she presented with a rapidly fatal, suspected EBV driven lymphoproliferative disorder in the CNS.

Conclusions

Our report further underlines that patients treated with Ruxolitinib should be monitored closely for reactivations of opportunistic pathogens and viral infections.

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Title: Case-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib
Authors: Róbert Pálmason
Ola Lindén
Johan Richter
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Hematology / Issue 1/2015
Electronic ISSN: 2052-1839
DOI: https://doi.org/10.1186/s12878-015-0029-1

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Case-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib

Abstract

Background

Case presentation

Conclusions

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Abstract

Background

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Conclusions

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