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BMC Geriatrics
Published in: BMC Geriatrics 1/2020

Open Access 01-12-2020 | Dementia | Study protocol

Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol

Authors: Mariagnese Barbera, Jenni Kulmala, Inna Lisko, Eija Pietilä, Anna Rosenberg, Ilona Hallikainen, Merja Hallikainen, Tiina Laatikainen, Jenni Lehtisalo, Elisa Neuvonen, Minna Rusanen, Hilkka Soininen, Jaakko Tuomilehto, Tiia Ngandu, Alina Solomon, Miia Kivipelto

Published in: BMC Geriatrics | Issue 1/2020

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Abstract

Background

The oldest old is the fastest growing age group worldwide and the most prone to severe disability, especially in relation to loss of cognitive function. Improving our understanding of the predictors of cognitive, physical and psychosocial wellbeing among the oldest old can result in substantial benefits for the individuals and for the society as a whole.
The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study investigated risk factors and determinants of cognitive impairment in a population-based longitudinal cohort, which was first examined between 1972 and 1992, when individuals were in their midlife, and re-assessed in 1998 and 2005–2009. Most of the study participants are currently aged 85 years or older. We aim to re-examine the cohort’s survivors and gain further insights on the mechanisms underlying both cognitive and overall healthy ageing at old age.

Methods

CAIDE85+ is the third follow-up of the CAIDE study participants. All individuals still alive and living in the Kuopio and Joensuu areas of Eastern Finland, from the original CAIDE cohort (two random samples, N = 2000 + ~ 900), will be invited to a re-examination. The assessment includes self-reported data related to basic demographics and lifestyle, as well as psychosocial and physical health status. Cognitive and physical evaluations are also conducted. Blood biomarkers relevant for dementia and ageing are assessed.
Primary outcomes are the measurements related to cognition and daily life functioning (CERAD, Trail Making Test-A, Letter-Digit Substitution Test, Clinical Dementia Rating and Activities of Daily Living). Secondary endpoints of the study are outcomes related to physical health status, psychosocial wellbeing, as well as age-related health indicators.

Discussion

Through a follow-up of more than 40 years, CAIDE85+ will provide invaluable information on the risk and protective factors that contribute to cognitive and physical health, as well as ageing and longevity.

Study registration

The present study protocol has been registered at https://​clinicaltrials.​gov/​ (registration nr NCT03938727, date 03.05.2019).
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Metadata
Title
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol
Authors
Mariagnese Barbera
Jenni Kulmala
Inna Lisko
Eija Pietilä
Anna Rosenberg
Ilona Hallikainen
Merja Hallikainen
Tiina Laatikainen
Jenni Lehtisalo
Elisa Neuvonen
Minna Rusanen
Hilkka Soininen
Jaakko Tuomilehto
Tiia Ngandu
Alina Solomon
Miia Kivipelto
Publication date
01-12-2020
Publisher
BioMed Central
Keywords
Dementia
Dementia
Published in
BMC Geriatrics / Issue 1/2020
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-020-01617-5

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