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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2020

Open Access 01-12-2020 | Dermatitis Herpetiformis | Review

An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects

Authors: Nazanin Taraghikhah, Sara Ashtari, Nastaran Asri, Bijan Shahbazkhani, David Al-Dulaimi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mohammad Reza Razzaghi, Mohammad Reza Zali

Published in: BMC Gastroenterology | Issue 1/2020

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Abstract

The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated at approximately 5% of the population. Celiac disease (CD), dermatitis herpetiformis (DH), gluten ataxia (GA), wheat allergy (WA), and non-celiac gluten sensitivity (NCGS) are the five major GRDs that present with a wide range of clinical manifestations. The diagnosis of GRDs can be challenging because the typical and atypical clinical manifestations of the GRDs overlap. In this review, the current definitions of gluten-related disorders, focusing on their clinical features, diagnostic and therapeutic approaches are presented. We concluded that GRDs are usually diagnosed using a combination of clinical features, serological tests, and histopathological findings. Treatment usually involves dietary modification.
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Footnotes
1
Anti-transglutaminase 6 Antibody
 
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Metadata
Title
An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects
Authors
Nazanin Taraghikhah
Sara Ashtari
Nastaran Asri
Bijan Shahbazkhani
David Al-Dulaimi
Mohammad Rostami-Nejad
Mostafa Rezaei-Tavirani
Mohammad Reza Razzaghi
Mohammad Reza Zali
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2020
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-020-01390-0

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