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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2015

Open Access 01-12-2015 | Case report

Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old man with glycogenosis 1b

Authors: Magdalena Sarah Volz, Mani Nassir, Christoph Treese, Moritz von Winterfeld, Ursula Plöckinger, Hans-Jörg Epple, Britta Siegmund

Published in: BMC Gastroenterology | Issue 1/2015

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Abstract

Background

Inflammatory bowel disease (IBD)-like conditions in glycogen storage disease (GSD) type Ib have been predominantly described in children. Signs and symptoms of GSD type Ib are hypoglycemia, pancytopenia and hepatosplenomegaly. Based on few published cases, there is evidence that granulocyte-colony stimulating factor (G-CSF) in patients with glycogenosis–related pancytopenia might ameliorate the IBD-like disease through leukocyte increase.

Case presentation

Here we firstly describe a case of an adult 33-year-old Caucasian male patient with GSD type Ib accompanied with IBD-like disease with persistent pancytopenia despite moderate-dose G-CSF treatment. Recent vomiting and abdominal discomfort were due to a high-grade stenosis in the transverse colon. A dose increase of the G-CSF successfully normalized his leukocyte count. However, the stenosis worsened and surgical therapy was needed.

Conclusion

We suggest that symptomatic patients with GSD type Ib should undergo endoscopic examination in order to detect IBD-like disease and to initiate early treatment.
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Metadata
Title
Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old man with glycogenosis 1b
Authors
Magdalena Sarah Volz
Mani Nassir
Christoph Treese
Moritz von Winterfeld
Ursula Plöckinger
Hans-Jörg Epple
Britta Siegmund
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2015
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-015-0271-9

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