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Open Access 01-12-2021 | Myocardial Infarction | Research article

Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease

Authors: Damir Raljević, Viktor Peršić, Elitza Markova-Car, Leon Cindrić, Rajko Miškulin, Marta Žuvić, Sandra Kraljević Pavelić

Published in: BMC Cardiovascular Disorders | Issue 1/2021

Abstract

Background

Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms—Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)—in a cohort of CAD patients after acute myocardial infarction.

Methods

In the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR.

Results

The results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction.

Conclusion

The presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.

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Title: Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease
Authors: Damir Raljević
Viktor Peršić
Elitza Markova-Car
Leon Cindrić
Rajko Miškulin
Marta Žuvić
Sandra Kraljević Pavelić
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Myocardial Infarction
Arterial Diseases
Published in: BMC Cardiovascular Disorders / Issue 1/2021
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-021-01959-x

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Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease

Abstract

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Conclusion

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