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BMC Cardiovascular Disorders
Published in: BMC Cardiovascular Disorders 1/2020

Open Access 01-12-2020 | Heart Failure | Research article

Physical functional performance and prognosis in patients with heart failure: a systematic review and meta-analysis

Authors: Iván José Fuentes-Abolafio, Brendon Stubbs, Luis Miguel Pérez-Belmonte, María Rosa Bernal-López, Ricardo Gómez-Huelgas, Antonio Ignacio Cuesta-Vargas

Published in: BMC Cardiovascular Disorders | Issue 1/2020

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Abstract

Background

Patients with Heart Failure (HF) show impaired functional capacities which have been related to their prognosis. Moreover, physical functional performance in functional tests has also been related to the prognosis in patients with HF. Thus, it would be useful to investigate how physical functional performance in functional tests could determine the prognosis in patients with HF, because HF is the leading cause of hospital admissions for people older than 65 years old. This systematic review and meta-analysis aims to summarise and synthesise the evidence published about the relationship between physical functional performance and prognosis in patients with HF, as well as assess the risk of bias of included studies and the level of evidence per outcome.

Methods

Major electronic databases, such as PubMed, AMED, CINAHL, EMBASE, PEDro, Web of Science, were searched from inception to March 2020 for observational longitudinal cohort studies (prospective or retrospective) examining the relationship between physical functional performance and prognosis in patients with HF.

Results

44 observational longitudinal cohort studies with a total of 22,598 patients with HF were included. 26 included studies reported a low risk of bias, and 17 included studies showed a moderate risk of bias. Patients with poor physical functional performance in the Six Minute Walking Test (6MWT), in the Short Physical Performance Battery (SPPB) and in the Gait Speed Test showed worse prognosis in terms of larger risk of hospitalisation or mortality than patients with good physical functional performance. However, there was a lack of homogeneity regarding which cut-off points should be used to stratify patients with poor physical functional performance from patients with good physical functional performance.

Conclusion

The review includes a large number of studies which show a strong relationship between physical functional performance and prognosis in patients with HF. Most of the included studies reported a low risk of bias, and GRADE criteria showed a low and a moderate level of evidence per outcome.
Appendix
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Metadata
Title
Physical functional performance and prognosis in patients with heart failure: a systematic review and meta-analysis
Authors
Iván José Fuentes-Abolafio
Brendon Stubbs
Luis Miguel Pérez-Belmonte
María Rosa Bernal-López
Ricardo Gómez-Huelgas
Antonio Ignacio Cuesta-Vargas
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Heart Failure
Published in
BMC Cardiovascular Disorders / Issue 1/2020
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-020-01725-5

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