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BMC Cardiovascular Disorders

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Open Access 01-12-2019 | Aneurysm | Research article

Meta-analysis of the growth rates of abdominal aortic aneurysm in the Chinese population

Authors: Tingting Huang, Shuai Liu, Jianhua Huang, Baohui Xu, Yongping Bai, Wei Wang

Published in: BMC Cardiovascular Disorders | Issue 1/2019

Abstract

Background

Several studies on the growth rates of abdominal aortic aneurysm (AAA) in Chinese population have been conducted; however, this issue remains unclear. The aim of this study is to systematically review published data of the AAA growth rates among people in China.

Methods

We conducted a comprehensive search of multiple databases to identify all studies of AAA growth in the Chinese population from inception until June 2017. AAA growth rates were combined to yield the growth rates at specified aneurysm diameter ranges, with using a random-effects model or fixed-effects model according to heterogeneity.

Results

A total of 8257 studies were initially identified and only 4 studies were eventually included. A random-effects analysis showed that the growth rates of AAA in Chinses population is ranging from 0.18 cm/year to 0.75 cm/year. The pooled mean growth rates among individuals with aneurysm measuring 3.0–3.9 cm, 4.0–5.9 cm and ≧ 6.0 cm in diameter were 0.21 cm/year (95% CI: 0.19 cm/year to 0.23 cm/year), 0.38 cm/year (95% CI: 0.33 cm/year to 0.43 cm/year), and 0.71 cm/year (95% CI: 0.64 cm/year to 0.77 cm/year) respectively. Further analysis found that the pooled mean growth rates for individuals with small AAA (diameters measuring 3.0–4.9 cm) was 0.28 cm/year (95% CI: − 0.06 cm/year to 0.61 cm/year)`and for individuals with large AAA (diameters ≥5.0 cm) was 0.75 cm/year (95% CI: 0.20 cm/year to 1.3 cm/year). Finally, meta-regression showed a strong trend of linear relationship between AAA growth rate and aneurysm diameter.

Conclusions

The growth rates of AAA in the Chinese population increase with AAA enlargement and appear to range from 0.18 cm/year in the smallest AAAs to 0.75 cm/year when the diameter exceeds 6 cm. However, based on current studies, it is difficult to estimate the accurate average AAA growth rate in Chinese patients. More large-scale, high-quality studies are required to achieve that. Overall, AAA growth rate increase with increased aneurysm diameter.

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Title: Meta-analysis of the growth rates of abdominal aortic aneurysm in the Chinese population
Authors: Tingting Huang
Shuai Liu
Jianhua Huang
Baohui Xu
Yongping Bai
Wei Wang
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Aneurysm
Aneurysm
Abdominal Aortic Aneurysm
Abdominal Aortic Aneurysm
Published in: BMC Cardiovascular Disorders / Issue 1/2019
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-019-1160-x

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