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BMC Cardiovascular Disorders
Published in: BMC Cardiovascular Disorders 1/2020

Open Access 01-12-2020 | Estradiol | Research article

Impact of liver damage on blood-borne variables and pulmonary hemodynamic responses to hypoxia and hyperoxia in anesthetized rats

Authors: Ali Sepehrinezhad, Amirreza Dehghanian, Ali Rafati, Farzaneh Ketabchi

Published in: BMC Cardiovascular Disorders | Issue 1/2020

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Abstract

Background

Liver disorders may be associated with normal pulmonary hemodynamic, hepatopulmonary syndrome (HPS), or portopulmonary hypertension (POPH). In this study, we aimed to investigate the effect of the severity of liver dysfunctions on blood-borne variables, and pulmonary hemodynamic during repeated ventilation with hyperoxic and hypoxic gases.

Methods

Female Sprague Dawley rats were assigned into four groups of Sham (n = 7), portal vein ligation (PPVL, n = 7), common bile duct ligation (CBDL, n = 7), and combination of them (CBDL+ PPVL, n = 7). Twenty-eight days later, right ventricular systolic pressure (RVSP) and systemic blood pressure were recorded in anesthetized animals subjected to repeated maneuvers of hyperoxia (O2 50%) and hypoxia (O2 10%). Besides, we assessed blood parameters and liver histology.

Results

Liver histology score, liver enzymes, WBC and plasma malondialdehyde in the CBDL+PPVL group were higher than those in the CBDL group. Also, the plasma platelet level in the CBDL+PPVL group was lower than those in the other groups. On the other hand, the serum estradiol in the CBDL group was higher than that in the CBDL+PPVL group. All the above parameters in the PPVL group were similar to those in the Sham group. During ventilation with hyperoxia gas, RVSP in the CBDL+PPVL group was higher than the ones in the other groups, and in the CBDL group, it was more than those in the PPVL and Sham groups. Hypoxic pulmonary vasoconstriction (HPV) was not detected in both CBDL+PPVL and CBDL groups, whereas, it retained in the PPVL group.

Conclusion

Severe liver damage increases RVSP in the CBDL+PPVL group linked to the high level of ROS, low levels of serum estradiol and platelets or a combination of them. Furthermore, the high RVSP at the noted group could present a reliable animal model for POPH in female rats.
Literature
1.
Herve P, Le Pavec J, Sztrymf B, Decante B, Savale L, Sitbon O. Pulmonary vascular abnormalities in cirrhosis. Best Pract Res Clin Gastroenterol. 2007;21(1):141–59.PubMedCrossRef
2.
3.
Benjaminov FS, Prentice M, Sniderman KW, Siu S, Liu P, Wong F. Portopulmonary hypertension in decompensated cirrhosis with refractory ascites. Gut. 2003;52(9):1355–62.PubMedPubMedCentralCrossRef
4.
Yang YY, Lin HC, Lee WC, Hou MC, Lee FY, Chang FY, Lee SD. Portopulmonary hypertension: distinctive hemodynamic and clinical manifestations. J Gastroenterol. 2001;36(3):181–6.PubMedCrossRef
5.
Krowka MJ, Mandell MS, Ramsay MA, Kawut SM, Fallon MB, Manzarbeitia C, Pardo M Jr, Marotta P, Uemoto S, Stoffel MP, et al. Hepatopulmonary syndrome and portopulmonary hypertension: a report of the multicenter liver transplant database. Liver Transpl. 2004;10(2):174–82.PubMedCrossRef
6.
Terao M, Takaki A, Maruyama T, Oe H, Yasunaka T, Tamaki N, Nakamura K, Tomofuji T, Yagi T, Sadamori H, et al. Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study. Intern Med. 2015;54(22):2815–26.PubMedCrossRef
7.
Zhang J, Yang W, Luo B, Hu B, Maheshwari A, Fallon MB. The role of CX(3)CL1/CX(3)CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental Hepatopulmonary syndrome. J Hepatol. 2012;57(4):752–8.PubMedPubMedCentralCrossRef
8.
Medarov BI, Chopra A, Judson MA. Clinical aspects of portopulmonary hypertension. Respir Med. 2014;108(7):943–54.PubMedCrossRef
9.
Raevens S, Geerts A, Van Steenkiste C, Verhelst X, Van Vlierberghe H, Colle I. Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment. Liver Int. 2015;35(6):1646–60.PubMedCrossRef
10.
11.
Luo B, Liu L, Tang L, Zhang J, Stockard CR, Grizzle WE, Fallon MB. Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome. J Hepatol. 2003;38(5):556–63.PubMedCrossRef
12.
Zhang J, Ling Y, Tang L, Luo B, Pollock DM, Fallon MB. Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats. Am J Physiol Gastrointest Liver Physiol. 2009;296(4):G704–8.PubMedPubMedCentralCrossRef
13.
Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension. Eur Respir J. 2000;15(4):640–8.PubMedCrossRef
14.
Khoramzadeh M, Dehghanian A, Ketabchi F. Roles of Endothelin B receptors and endothelial nitric oxide synthase in the regulation of pulmonary hemodynamic in cirrhotic rats. J Cardiovasc Pharmacol. 2019;73(3):178–85.PubMedCrossRef
15.
Vujanac A, Jakovljevic V, Djordjevic D, Zivkovic V, Stojkovic M, Celikovic D, Andjelkovic N, Skevin AJ, Djuric D. Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension. World J Gastroenterol. 2012;18(4):331–9.PubMedPubMedCentralCrossRef
16.
Angermayr B, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J, Fernandez M. Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats. J Hepatol. 2006;44(6):1033–9.PubMedCrossRef
17.
Izzet T, Osman K, Ethem U, Nihat Y, Ramazan K, Mustafa D, Hafize U, Riza KA, Birsen A, Habibe G, et al. Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals. World J Gastroenterol. 2005;11(23):3570–3.PubMedPubMedCentralCrossRef
18.
Nacif LS, Andraus W, Kubrusly MS, Kubrusly FS, Gebara VC, Ishizawa A, D'Albuquerque LA. Surfactant protein a is decreased in the lung of rats with hepatopulmonary syndrome. Acta Cir Bras. 2014;29(9):573–8.PubMedCrossRef
19.
Incalza MA, D'Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vasc Pharmacol. 2018;100:1–19.CrossRef
20.
Ferrari RS, Tieppo M, Rosa DP, Forgiarini LA Jr, Dias AS, Marroni NP. Lung and liver changes due to the induction of cirrhosis in two experimental models. Arq Gastroenterol. 2013;50(3):208–13.PubMedCrossRef
21.
Hiyama E. Pulmonary vascular changes after portasystemic shunt operation in rats. Nihon Geka Gakkai zasshi. 1989;90(6):874–85.PubMed
22.
Yan G, He J, Yu Y, Liu Y, Yuan Y, Guo Z. Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomed Rep. 2016;4(1):51–4.PubMedCrossRef
23.
Frost AE, Badesch DB, Barst RJ, Benza RL, Elliott CG, Farber HW, Krichman A, Liou TG, Raskob GE, Wason P, et al. The changing picture of patients with pulmonary arterial hypertension in the United States: how REVEAL differs from historic and non-US contemporary registries. Chest. 2011;139(1):128–37.PubMedCrossRef
24.
Lahm T, Albrecht M, Fisher AJ, Selej M, Patel NG, Brown JA, Justice MJ, Brown MB, Van Demark M, Trulock KM, et al. 17beta-estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med. 2012;185(9):965–80.PubMedPubMedCentralCrossRef
25.
Tofovic SP, Zhang X, Jackson EK, Dacic S, Petrusevska G. 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension. Vasc Pharmacol. 2006;45(6):358–67.CrossRef
26.
Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der Laarse A, Eghbali M. Estrogen rescues preexisting severe pulmonary hypertension in rats. Am J Respir Crit Care Med. 2011;184(6):715–23.PubMedPubMedCentralCrossRef
27.
Umar S, Rabinovitch M, Eghbali M. Estrogen paradox in pulmonary hypertension: current controversies and future perspectives. Am J Respir Crit Care Med. 2012;186(2):125–31.PubMedPubMedCentralCrossRef
28.
Kobayashi H, Yoshida S, Sun YJ, Shirasawa N, Naito A. Gastric estradiol-17beta (E2) and liver ERalpha correlate with serum E2 in the cholestatic male rat. J Endocrinol. 2013;219(1):39–49.PubMedCrossRef
29.
Kobayashi H, Yoshida S, Sun YJ, Shirasawa N, Naito A. 17beta-estradiol in the systemic circulation derives mainly from the parietal cells in cholestatic female rats. J Endocrinol Investig. 2016;39(4):389–400.CrossRef
30.
Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, Shah VH, Kaplowitz N, Forman L, Wille K, et al. Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008;135(4):1168–75.PubMedCrossRef
31.
Santa-Cruz RA, Pearson MD, Cohen MG, Shrestha R, Willis PW, Hinderliter A, Menon V. Clinical predictors and characteristics of patients with chronic liver disease and intrapulmonary shunts. Clin Cardiol. 2005;28(9):437–41.PubMedCrossRef
32.
Schenk P, Fuhrmann V, Madl C, Funk G, Lehr S, Kandel O, Muller C. Hepatopulmonary syndrome: prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences. Gut. 2002;51(6):853–9.PubMedPubMedCentralCrossRef
33.
Luo B, Liu L, Tang L, Zhang J, Ling Y, Fallon MB. ET-1 and TNF-alpha in HPS: analysis in prehepatic portal hypertension and biliary and nonbiliary cirrhosis in rats. Am J Physiol Gastrointest Liver Physiol. 2004;286(2):G294–303.PubMedCrossRef
34.
35.
Nunes H, Lebrec D, Mazmanian M, Capron F, Heller J, Tazi KA, Zerbib E, Dulmet E, Moreau R, Dinh-Xuan AT, et al. Role of nitric oxide in hepatopulmonary syndrome in cirrhotic rats. Am J Respir Crit Care Med. 2001;164(5):879–85.PubMedCrossRef
36.
Cora MC, Kooistra L, Travlos G. Vaginal cytology of the laboratory rat and mouse: review and criteria for the staging of the estrous cycle using stained vaginal smears. Toxicol Pathol. 2015;43(6):776–93.PubMedCrossRef
37.
Schwenke D, Pearson J, Tsuchimochi H, Kangawa K, Shirai M. Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide. Clin Exp Pharmacol Physiol. 2007;34(1–2):88–94.PubMedCrossRef
38.
Ketabchi F, Bajoovand S, Adlband M, Naseh M, Nekooeian AA, Mashghoolozekr E. Right ventricular pressure elevated in one-kidney, one clip Goldblatt hypertensive rats. Clin Exp Hypertens(New York, NY : 1993). 2017;39(4):344–9.
39.
Koizuka S, Obata H, Sasaki M, Saito S, Goto F. Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats. Can J Anaesth. 2005;52(5):498–505.PubMedCrossRef
40.
Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Van Groen T, Grizzle WE, Ponnazhagan S, Fallon MB. Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Gastroenterology. 2009;136(3):1070–80.PubMedCrossRef
41.
Rodrigues DA, da Silva AR, Serigiolle LC, Fidalgo Rde S, Favero SS, Leme PL. Constriction rate variation produced by partial ligation of the portal vein at pre-hepatic portal hypertension induced in rats. Arq Bras Cir Dig. 2014;27(4):280–4.PubMedPubMedCentralCrossRef
42.
Walkowska A, Skaroupkova P, Huskova Z, Vanourkova Z, Chabova VC, Tesar V, Kramer HJ, Falck JR, Imig JD, Kompanowska-Jezierska E, et al. Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats. J Hypertens. 2010;28(3):582–93.PubMedPubMedCentralCrossRef
43.
Strubelt O, Younes M. Influence of hypoxia and hyperoxia on the cardiovascular and lethal effects of ethanol. Pharmacol Toxicol. 1999;84(3):101–6.PubMedCrossRef
44.
45.
Hinojosa-Laborde C, Mifflin SW. Sex differences in blood pressure response to intermittent hypoxia in rats. Hypertension. 2005;46(4):1016–21.PubMedCrossRef
46.
Edmunds N, Marshall JM. Vasodilatation, oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: roles of nitric oxide. J Physiol. 2001;532(1):251–9.PubMedPubMedCentralCrossRef
47.
Goodman ZD. Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol. 2007;47(4):598–607.PubMedCrossRef
48.
Karimi Z, Ketabchi F, Alebrahimdehkordi N, Fatemikia H, Owji SM, Moosavi SM. Renal ischemia/reperfusion against nephrectomy for induction of acute lung injury in rats. Ren Fail. 2016;38(9):1503–15.PubMedCrossRef
49.
Mansoori S, Moosavi SMS, Ketabchi F. The interaction between Trolox and 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid on hypoxic pulmonary vasoconstriction in the isolated rabbit lung. Iran J Med Sci. 2017;42(3):284–91.PubMedPubMedCentral
50.
Earley S, Resta TC. Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression. Am J Physiol Lung Cell Mol Physiol. 2002;283(1):L86–93.PubMedCrossRef
51.
Tofovic SP, Salah EM, Mady HH, Jackson EK, Melhem MF. Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol. 2005;46(4):430–7.PubMedCrossRef
52.
Ciarlone GE, Dean JB. Normobaric hyperoxia stimulates superoxide and nitric oxide production in the caudal solitary complex of rat brain slices. Am J Physiol Cell Physiol. 2016;311(6):C1014–c1026.PubMedCrossRef
53.
Moller S, Bendtsen F. The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis. Liver Int. 2018;38(4):570–80.PubMedCrossRef
54.
Moezi L, Gaskari S, Liu H, Baik S, Dehpour A, Lee S. Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB1 and VR1 receptors. Br J Pharmacol. 2006;149(7):898–908.PubMedPubMedCentralCrossRef
55.
Winkler L, Lhuissier FJ, Richalet JP. Systemic blood pressure at exercise in hypoxia in hypertensive and normotensive patients. J Hypertens. 2017;35(12):2402–10.PubMedCrossRef
56.
Marcus NJ, Olson EB Jr, Bird CE, Philippi NR, Morgan BJ. Time-dependent adaptation in the hemodynamic response to hypoxia. Respir Physiol Neurobiol. 2009;165(1):90–6.PubMedCrossRef
57.
Siebenmann C, Lundby C. Regulation of cardiac output in hypoxia. Scand J Med Sci Sports. 2015;25(Suppl 4):53–9.PubMedCrossRef
58.
Cowburn AS, Macias D, Summers C, Chilvers ER. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. Elife. 2017;6.
59.
Cowburn AS, Macias D, Summers C, Chilvers ER, and Johnson RS. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. eLIFE. 2017;6:1-23.
60.
Thomson AJ, Drummond GB, Waring WS, Webb DJ, Maxwell SR. Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function. J Appl Physiol. 2006;101(3):809–16.PubMedCrossRef
61.
Iwasaki K, Ogawa Y, Shibata S, Aoki K. Acute exposure to normobaric mild hypoxia alters dynamic relationships between blood pressure and cerebral blood flow at very low frequency. J Cereb Blood Flow Metab. 2007;27(4):776–84.PubMedCrossRef
62.
Barton CH, Ni Z, Vaziri ND. Blood pressure response to hypoxia: role of nitric oxide synthase. Am J Hypertens. 2003;16(12):1043–8.PubMedCrossRef
63.
Bosc LVG, Resta T, Walker B, Kanagy NL. Mechanisms of intermittent hypoxia induced hypertension. J Cell Mol Med. 2010;14(1–2):3–17.PubMedCrossRef
64.
Foster GE, Hanly PJ, Ahmed SB, Beaudin AE, Pialoux V, Poulin MJ. Intermittent hypoxia increases arterial blood pressure in humans through a renin-angiotensin system-dependent mechanism. Hypertension. 2010;56(3):369–77.PubMedCrossRef
65.
Stowe DF, Bosnjak ZJ, Kampine JP. Effects of hypoxia on adult and neonatal pacemaker rates. Obstet Gynecol. 1985;66(5):649–56.PubMed
66.
Gole Y, Gargne O, Coulange M, Steinberg JG, Bouhaddi M, Jammes Y, Regnard J, Boussuges A. Hyperoxia-induced alterations in cardiovascular function and autonomic control during return to normoxic breathing. Eur J Appl Physiol. 2011;111(6):937–46.PubMedCrossRef
67.
Rodriguez-Roisin R, Krowka MJ, Agusti A. Hepatopulmonary disorders: gas exchange and vascular manifestations in chronic liver disease. Compr Physiol. 2018;8(2):711–29.PubMedCrossRef
68.
Deibert P, Allgaier HP, Loesch S, Muller C, Olschewski M, Hamm H, Maier KP, Blum HE. Hepatopulmonary syndrome in patients with chronic liver disease: role of pulse oximetry. BMC Gastroenterol. 2006;6:15.PubMedPubMedCentralCrossRef
69.
Gomez FP, Martinez-Palli G, Barbera JA, Roca J, Navasa M, Rodriguez-Roisin R. Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome. Hepatology. 2004;40(3):660–6.PubMedCrossRef
70.
Halank M, Miehlke S, Kolditz M, Hoeffken G. Portopulmonary hypertension. Zeitschrift fur Gastroenterologie. 2005;43(7):677–85.PubMedCrossRef
71.
Huang YT, Hsu YC, Chen CJ, Liu CT, Wei YH. Oxidative-stress-related changes in the livers of bile-duct-ligated rats. J Biomed Sci. 2003;10(2):170–8.PubMedCrossRef
72.
Sommer N, Strielkov I, Pak O, Weissmann N. Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. Eur Respir J. 2016;47(1):288–303.PubMedCrossRef
73.
Casey DB, Pankey EA, Badejo AM, Bueno FR, Bhartiya M, Murthy SN, Uppu RM, Nossaman BD, Kadowitz PJ. Peroxynitrite has potent pulmonary vasodilator activity in the rat. Can J Physiol Pharmacol. 2012;90(4):485–500.PubMedCrossRef
74.
Battista S, Bar F, Mengozzi G, Zanon E, Grosso M, Molino G. Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins. J Hepatol. 1997;26(1):75–80.PubMedCrossRef
75.
Oswald-Mammosser M, Rashid S, Boehm N, Agin A, Geny B, Schini-Kerth V, Charloux A. Effect of the oestrogen receptor antagonist fulvestrant on the cirrhotic rat lung. Fundam Clin Pharmacol. 2015;29(3):269–77.PubMedCrossRef
76.
Bosch J, Abraldes JG, Fernandez M, Garcia-Pagan JC. Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. J Hepatol. 2010;53(3):558–67.PubMedCrossRef
77.
White RE, Gerrity R, Barman SA, Han G. Estrogen and oxidative stress: a novel mechanism that may increase the risk for cardiovascular disease in women. Steroids. 2010;75(11):788–93.PubMedPubMedCentralCrossRef
78.
Taguchi H, Kataoka M, Yanagisawa R, Kawakami T, Tamura Y, Fukuda K, Yoshino H, Satoh T. Platelet level as a new prognostic factor for idiopathic pulmonary arterial hypertension in the era of combination therapy. Circ J. 2012;76(6):1494–500.PubMedCrossRef
79.
Mojadidi MK, Goodman-Meza D, Eshtehardi P, Pamerla M, Msaouel P, Roberts SC, Winoker JS, Jadeja NM, Zolty R. Thrombocytopenia is an independent predictor of mortality in pulmonary hypertension. Heart Lung. 2014;43(6):569–73.PubMedCrossRef
80.
Elias JE, Mackie I, Eapen CE, Chu P, Shaw JC, Elias E. Porto-pulmonary hypertension exacerbated by platelet transfusion in a patient with ADAMTS13 deficiency. J Hepatol. 2013;58(4):827–30.PubMedCrossRef
81.
Hayashi H, Beppu T, Shirabe K, Maehara Y, Baba H. Management of thrombocytopenia due to liver cirrhosis: a review. World J Gastroenterol. 2014;20(10):2595–605.PubMedPubMedCentralCrossRef
82.
Budhiraja R, Hassoun PM. Portopulmonary hypertension: a tale of two circulations. Chest. 2003;123(2):562–76.PubMedCrossRef
83.
Porres-Aguilar M, Altamirano JT, Torre-Delgadillo A, Charlton MR, Duarte-Rojo A. Portopulmonary hypertension and hepatopulmonary syndrome: a clinician-oriented overview. Eur Respir Rev. 2012;21(125):223–33.PubMedCrossRef
Metadata
Title
Impact of liver damage on blood-borne variables and pulmonary hemodynamic responses to hypoxia and hyperoxia in anesthetized rats
Authors
Ali Sepehrinezhad
Amirreza Dehghanian
Ali Rafati
Farzaneh Ketabchi
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Estradiol
Published in
BMC Cardiovascular Disorders / Issue 1/2020
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-019-01297-z

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