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BMC Cardiovascular Disorders

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Open Access 01-12-2017 | Research article

Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis

Authors: Yu-Jie Shi, Jun Lv, Xing-Ting Han, Guo-Gang Luo

Published in: BMC Cardiovascular Disorders | Issue 1/2017

Abstract

Background

The association between patent foramen ovale (PFO) and migraine with aura (MA) is well established. However, the benefits of PFO closure are less certain in patients with migraine without aura (MwoA).

Methods

We systematically searched Pubmed for pertinent clinical studies published from January 2000 to July 2015. The primary end-point was the elimination or significant improvement of migraine symptoms after PFO closure.

Results

Upon screening an initial list of 315 publications, we identified eight studies that included 546 patients. Overall, our analysis indicated a significant improvement of migraine in 81% of MA cases compared to only 63% of MwoA cases. The summary odds ratio was 2.5 (95% confidence interval 1.09–5.73), and the benefits of PFO closure were significantly greater for patients with MA compared to patients with MwoA (P = 0.03).

Conclusions

The presence of aura provides a reference standard for the clinical selection of patients with migraine for PFO closure intervention.

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Title: Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis
Authors: Yu-Jie Shi
Jun Lv
Xing-Ting Han
Guo-Gang Luo
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2017
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-017-0644-9

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