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BMC Cardiovascular Disorders

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Open Access 01-12-2017 | Research article

Change in renin, cardiovascular and inflammatory markers over three years in a black and white population: the SABPA study

Authors: Rijané Swart, Johannes M. van Rooyen, Catharina M. C. Mels

Published in: BMC Cardiovascular Disorders | Issue 1/2017

Abstract

Background

To investigate if percentage change (%∆) in renin over a 3 year follow-up is associated with %∆ in cardiovascular and inflammatory markers in a low renin bi-ethnic group.

Methods

Blood pressure, active renin, C-reactive protein and interleukin-6 levels of 73 black and 81 white teachers were measured at baseline and after 3 years.

Results

In the black group, %∆ renin was inversely associated with %∆ systolic blood pressure (β = −0.27; p = 0.011). In the white group %∆ renin was inversely associated with %∆interleukin-6 (β = −0.24; p = 0.005).

Conclusions

These prospective results indicate that a decrease in renin over time is associated with an increase in blood pressure in a low renin black South African cohort.

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Title: Change in renin, cardiovascular and inflammatory markers over three years in a black and white population: the SABPA study
Authors: Rijané Swart
Johannes M. van Rooyen
Catharina M. C. Mels
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Cardiovascular Disorders / Issue 1/2017
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-017-0538-x

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