Skip to main content
Top
Published in: BMC Cardiovascular Disorders 1/2015

Open Access 01-12-2015 | Case report

Fractional flow reserve of non-culprit vessel post-myocardial infarction: is it reliable?

Authors: Luís Leite, Joana Moura Ferreira, João Silva Marques, Elisabete Jorge, Vítor Matos, Jorge Guardado, João Calisto, Mariano Pego

Published in: BMC Cardiovascular Disorders | Issue 1/2015

Login to get access

Abstract

Background

Multi-vessel disease is frequent in patients presenting with myocardial infarction and have an important prognostic impact. The decision to proceed to revascularization in non-culprit vessels can be postponed until ischemia is proven in non-invasive stress tests. On the other hand, there is an increasing evidence to support the role of fractional flow reserve (FFR) in acute coronary syndrome setting.

Case presentation

We report a case in which a FFR-guided strategy for non-culprit vessels, 3 weeks after an ST-segment elevation myocardial infarction, was followed by a short-term sub-occlusion of the evaluated vessel.

Conclusion

The timing of the coronary microcirculation recovery post-myocardial infarction, avoiding a possible false negative FFR, and the diagnostic gaps between ischemia and plaque vulnerability are under discussion. An FFR-guided strategy in this setting should be interpreted with caution.
Literature
1.
go back to reference Hasdai D, Behar S, Wallentin L, Danchin N, Gitt AK, Boersma E, et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS). Eur Heart J. 2002;23:1190–201.CrossRefPubMed Hasdai D, Behar S, Wallentin L, Danchin N, Gitt AK, Boersma E, et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS). Eur Heart J. 2002;23:1190–201.CrossRefPubMed
2.
go back to reference Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, et al. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. Eur Heart J. 2007;28:1709–16.CrossRefPubMed Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, et al. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. Eur Heart J. 2007;28:1709–16.CrossRefPubMed
3.
go back to reference Windecker S, Kolh P, Alfonso F, Collet J-P, Cremer J, Falk V, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2014;35:2541–619.CrossRefPubMed Windecker S, Kolh P, Alfonso F, Collet J-P, Cremer J, Falk V, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2014;35:2541–619.CrossRefPubMed
4.
go back to reference Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33:2569–619.CrossRefPubMed Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33:2569–619.CrossRefPubMed
5.
go back to reference Pijls NHJ, van Schaardenburgh P, Manoharan G, Boersma E, Bech J-W, van’ t Veer M, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol. 2007;49:2105–11.CrossRefPubMed Pijls NHJ, van Schaardenburgh P, Manoharan G, Boersma E, Bech J-W, van’ t Veer M, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol. 2007;49:2105–11.CrossRefPubMed
6.
go back to reference Tonino PAL, De Bruyne B, Pijls NHJ, Siebert U, Ikeno F, Van’ t Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213–24.CrossRefPubMed Tonino PAL, De Bruyne B, Pijls NHJ, Siebert U, Ikeno F, Van’ t Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213–24.CrossRefPubMed
7.
go back to reference Pijls NHJ, Fearon WF, Tonino PAL, Siebert U, Ikeno F, Bornschein B, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol. 2010;56:177–84.CrossRefPubMed Pijls NHJ, Fearon WF, Tonino PAL, Siebert U, Ikeno F, Bornschein B, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol. 2010;56:177–84.CrossRefPubMed
8.
go back to reference De Bruyne B, Pijls NHJ, Kalesan B, Barbato E, Tonino PAL, Piroth Z, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367:991–1001.CrossRefPubMed De Bruyne B, Pijls NHJ, Kalesan B, Barbato E, Tonino PAL, Piroth Z, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367:991–1001.CrossRefPubMed
9.
go back to reference Hennigan B, Layland J, Fearon WF, Oldroyd KG. Fractional flow reserve and the index of microvascular resistance in patients with acute coronary syndromes. EuroIntervention. 2014;10 Suppl T:T55–63.CrossRefPubMed Hennigan B, Layland J, Fearon WF, Oldroyd KG. Fractional flow reserve and the index of microvascular resistance in patients with acute coronary syndromes. EuroIntervention. 2014;10 Suppl T:T55–63.CrossRefPubMed
10.
go back to reference Claeys MJ, Bosmans JM, Hendrix J, Vrints CJ. Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: importance of flow on translesional pressure gradient. Catheter Cardiovasc Interv. 2001;54:427–34.CrossRefPubMed Claeys MJ, Bosmans JM, Hendrix J, Vrints CJ. Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: importance of flow on translesional pressure gradient. Catheter Cardiovasc Interv. 2001;54:427–34.CrossRefPubMed
11.
go back to reference Hamm CW, Bassand J-P, Agewall S, Bax J, Boersma E, Bueno H, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevatio. Eur Heart J. 2011;32:2999–3054.CrossRefPubMed Hamm CW, Bassand J-P, Agewall S, Bax J, Boersma E, Bueno H, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevatio. Eur Heart J. 2011;32:2999–3054.CrossRefPubMed
12.
go back to reference Ntalianis A, Sels J-W, Davidavicius G, Tanaka N, Muller O, Trana C, et al. Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction. JACC Cardiovasc Interv. 2010;3:1274–81.CrossRefPubMed Ntalianis A, Sels J-W, Davidavicius G, Tanaka N, Muller O, Trana C, et al. Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction. JACC Cardiovasc Interv. 2010;3:1274–81.CrossRefPubMed
13.
go back to reference Cuculi F, De Maria GL, Meier P, Dall’Armellina E, de Caterina AR, Channon KM, et al. Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2014;64:1894–904.CrossRefPubMed Cuculi F, De Maria GL, Meier P, Dall’Armellina E, de Caterina AR, Channon KM, et al. Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2014;64:1894–904.CrossRefPubMed
14.
go back to reference Fearon WF, Balsam LB, Farouque HMO, Robbins RC, Fitzgerald PJ, Yock PG, et al. Novel index for invasively assessing the coronary microcirculation. Circulation. 2003;107:3129–32.CrossRefPubMed Fearon WF, Balsam LB, Farouque HMO, Robbins RC, Fitzgerald PJ, Yock PG, et al. Novel index for invasively assessing the coronary microcirculation. Circulation. 2003;107:3129–32.CrossRefPubMed
15.
go back to reference Fearon WF, Shah M, Ng M, Brinton T, Wilson A, Tremmel JA, et al. Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2008;51:560–5.CrossRefPubMed Fearon WF, Shah M, Ng M, Brinton T, Wilson A, Tremmel JA, et al. Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2008;51:560–5.CrossRefPubMed
16.
go back to reference Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, et al. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226–35.CrossRefPubMed Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, et al. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226–35.CrossRefPubMed
17.
go back to reference Bourantas CV, Garcia-Garcia HM, Farooq V, Maehara A, Xu K, Généreux P, et al. Clinical and angiographic characteristics of patients likely to have vulnerable plaques: analysis from the PROSPECT study. JACC Cardiovasc Imaging. 2013;6:1263–72.CrossRefPubMed Bourantas CV, Garcia-Garcia HM, Farooq V, Maehara A, Xu K, Généreux P, et al. Clinical and angiographic characteristics of patients likely to have vulnerable plaques: analysis from the PROSPECT study. JACC Cardiovasc Imaging. 2013;6:1263–72.CrossRefPubMed
18.
go back to reference Yun KH, Mintz GS, Farhat N, Marso SP, Taglieri N, Verheye S, et al. Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree study). Am J Cardiol. 2012;110:471–7.CrossRefPubMed Yun KH, Mintz GS, Farhat N, Marso SP, Taglieri N, Verheye S, et al. Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree study). Am J Cardiol. 2012;110:471–7.CrossRefPubMed
19.
go back to reference Versteeg D, Hoefer IE, Schoneveld AH, de Kleijn DPV, Busser E, Strijder C, et al. Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve. Heart. 2008;94:770–6.CrossRefPubMed Versteeg D, Hoefer IE, Schoneveld AH, de Kleijn DPV, Busser E, Strijder C, et al. Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve. Heart. 2008;94:770–6.CrossRefPubMed
20.
go back to reference Waksman R, Legutko J, Singh J, Orlando Q, Marso S, Schloss T, et al. FIRST: Fractional Flow Reserve and Intravascular Ultrasound Relationship Study. J Am Coll Cardiol. 2013;61:917–23.CrossRefPubMed Waksman R, Legutko J, Singh J, Orlando Q, Marso S, Schloss T, et al. FIRST: Fractional Flow Reserve and Intravascular Ultrasound Relationship Study. J Am Coll Cardiol. 2013;61:917–23.CrossRefPubMed
21.
go back to reference Hüseyinova G, Aslanger E, Çakır O, Atıcı A, Panç C, Demirkıran A, et al. Potential contribution of virtual histology plaque composition to hemodynamic-morphologic dissociation in patients with non-ST elevation acute coronary syndrome. Int J Cardiol. 2015;187:33–8.CrossRefPubMed Hüseyinova G, Aslanger E, Çakır O, Atıcı A, Panç C, Demirkıran A, et al. Potential contribution of virtual histology plaque composition to hemodynamic-morphologic dissociation in patients with non-ST elevation acute coronary syndrome. Int J Cardiol. 2015;187:33–8.CrossRefPubMed
22.
go back to reference Smits PC, Vlachojannis GJ, Lunde K, Omerovic E, Schotborgh CE, Richardt G, et al. TCT-328 FFR-guided complete revascularization during primary PCI: Preliminary data from the COMPARE ACUTE trial. J Am Coll Cardiol. 2014;64:11_S. Smits PC, Vlachojannis GJ, Lunde K, Omerovic E, Schotborgh CE, Richardt G, et al. TCT-328 FFR-guided complete revascularization during primary PCI: Preliminary data from the COMPARE ACUTE trial. J Am Coll Cardiol. 2014;64:11_S.
Metadata
Title
Fractional flow reserve of non-culprit vessel post-myocardial infarction: is it reliable?
Authors
Luís Leite
Joana Moura Ferreira
João Silva Marques
Elisabete Jorge
Vítor Matos
Jorge Guardado
João Calisto
Mariano Pego
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2015
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-015-0122-1

Other articles of this Issue 1/2015

BMC Cardiovascular Disorders 1/2015 Go to the issue