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Open Access 01-12-2017 | Research article

A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score

Authors: Rogério da Hora Passos, João Gabriel Rosa Ramos, Evandro Jose Bulhoes Mendonça, Eva Alves Miranda, Fábio Ricardo Dantas Dutra, Maria Fernanda R. Coelho, Andrea C. Pedroza, Luis Claudio L. Correia, Paulo Benigno Pena Batista, Etienne Macedo, Margarida M. D. Dutra

Published in: BMC Anesthesiology | Issue 1/2017

Abstract

Background

This study aimed to identify predictors of early (7-day) mortality in patients with septic acute kidney injury (AKI) who required continuous renal replacement therapy (CRRT).

Methods

Prospective cohort of 186 septic AKI patients undergoing CRRT at a tertiary hospital, from October 2005 to November 2010.

Results

After multivariate adjustment, five variables were associated to early mortality: norepinephrine utilization, liver failure, medical condition, lactate level, and pre-dialysis creatinine level. These variables were combined in a score, which demonstrated good discrimination, with a C-statistic of 0.82 (95% CI = 0.76–0.88), and good calibration (χ ² = 4.3; p = 0.83). SAPS 3, APACHE II and SOFA scores demonstrated poor performance in this population.

Conclusions

The HEpatic failure, LactatE, NorepInephrine, medical Condition, and Creatinine (HELENICC) score outperformed tested generic models. Future studies should further validate this score in different cohorts.

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Title: A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score
Authors: Rogério da Hora Passos
João Gabriel Rosa Ramos
Evandro Jose Bulhoes Mendonça
Eva Alves Miranda
Fábio Ricardo Dantas Dutra
Maria Fernanda R. Coelho
Andrea C. Pedroza
Luis Claudio L. Correia
Paulo Benigno Pena Batista
Etienne Macedo
Margarida M. D. Dutra
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Anesthesiology / Issue 1/2017
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-017-0312-8

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Springer Medicine

A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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