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The Journal of Headache and Pain

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Open Access 01-12-2017 | Research article

Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma, Shengyuan Yu

Published in: The Journal of Headache and Pain | Issue 1/2017

Abstract

Background

Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods.

Methods

3D structure images and resting-state functional MRI data were obtained from 37 MOH patients, 18 episodic migraine (EM) patients and 32 normal controls (NCs). FCD was calculated to detect the brain regions with abnormal functional activity over the whole brain, and the seed-based RSFC was performed to explore the functional network changes in MOH and EM.

Results

The decreased FCD located in right parahippocampal gyrus, and the increased FCD located in left inferior parietal gyrus and right supramarginal gyrus in MOH compared with NC, and in right caudate and left insula in MOH compared with EM. RSFC revealed that decreased functional connectivity of the brain regions with decreased FCD anchored in the right dorsal-lateral prefrontal cortex, right frontopolar cortex in MOH, and in left temporopolar cortex and bilateral visual cortices in EM compared with NC, and in frontal-temporal-parietal pattern in MOH compared with EM.

Conclusions

These results provided evidence that MOH and EM suffered from altered intrinsic functional connectivity architecture, and the current study presented a new perspective for understanding the neuromechanism of MOH and EM pathogenesis.

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Title: Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI
Authors: Zhiye Chen
Xiaoyan Chen
Mengqi Liu
Zhao Dong
Lin Ma
Shengyuan Yu
Publication date: 01-12-2017
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-017-0735-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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