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Open Access 01-12-2002 | Review

Preneoplastic lesions of the lung

Authors: Alissa K Greenberg, Herman Yee, William N Rom

Published in: Respiratory Research | Issue 1/2001

Abstract

Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia/carcinoma in situ; atypical adenomatous hyperplasia; and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma in situ.

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Title: Preneoplastic lesions of the lung
Authors: Alissa K Greenberg
Herman Yee
William N Rom
Publication date: 01-12-2002
Publisher: BioMed Central
Published in: Respiratory Research / Issue 1/2001
Electronic ISSN: 1465-993X
DOI: https://doi.org/10.1186/rr170

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