Skip to main content
Top
Published in: Critical Care 1/2011

01-02-2011 | Review

Bench-to-bedside review: The role of C1-esterase inhibitor in sepsis and other critical illnesses

Authors: Mervyn Singer, Annie M Jones

Published in: Critical Care | Issue 1/2011

Login to get access

Abstract

The purpose of this bench-to-bedside review is to summarize the literature relating to complement activation in sepsis and other critical illnesses and the role of C1-esterase inhibitor (C1 INH) as a potential therapy.
Appendix
Available only for authorised users
Literature
1.
go back to reference Rambach G, Wurzner R, Speth C: Complement: an efficient sword of innate immunity. Contrib Microbiol 2008, 15: 78-100.PubMedCrossRef Rambach G, Wurzner R, Speth C: Complement: an efficient sword of innate immunity. Contrib Microbiol 2008, 15: 78-100.PubMedCrossRef
2.
go back to reference McPhaden AR, Whaley K: The complement system in sepsis and trauma. Br Med Bull 1985, 41: 281-286.PubMed McPhaden AR, Whaley K: The complement system in sepsis and trauma. Br Med Bull 1985, 41: 281-286.PubMed
9.
go back to reference Bas M, Adams V, Suvorava T, Niehues T, Hoffmann TK, Kojda G: Nonallergic angioedema: role of bradykinin. Allergy 2007, 62: 842-856.PubMedCrossRef Bas M, Adams V, Suvorava T, Niehues T, Hoffmann TK, Kojda G: Nonallergic angioedema: role of bradykinin. Allergy 2007, 62: 842-856.PubMedCrossRef
10.
go back to reference Cai S, Dole VS, Bergmeier W, Scafidi J, Feng H, Wagner DD, Davis AE: A direct role for C1 inhibitor in regulation of leukocyte adhesion. Immunol 2005, 174: 6462-6466.CrossRef Cai S, Dole VS, Bergmeier W, Scafidi J, Feng H, Wagner DD, Davis AE: A direct role for C1 inhibitor in regulation of leukocyte adhesion. Immunol 2005, 174: 6462-6466.CrossRef
11.
go back to reference Beinrohr L, Harmat V, Dobo J, Lorincz Z, Gal P, Zavodszky P: C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease. J Biol Chem 2007, 282: 21100-21109.PubMedCrossRef Beinrohr L, Harmat V, Dobo J, Lorincz Z, Gal P, Zavodszky P: C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease. J Biol Chem 2007, 282: 21100-21109.PubMedCrossRef
12.
go back to reference Landerman NS, Webster ME, Becker EL, Ratcliffe HE: Hereditary angioneurotic edema. II. Deficiency of inhibitor for serum globulin permeability factor and/or plasma kallikrein. J Allergy 1962, 33: 330-341.PubMedCrossRef Landerman NS, Webster ME, Becker EL, Ratcliffe HE: Hereditary angioneurotic edema. II. Deficiency of inhibitor for serum globulin permeability factor and/or plasma kallikrein. J Allergy 1962, 33: 330-341.PubMedCrossRef
13.
go back to reference Albrecht EA, Ward PA: Complement-induced impairment of the innate immune system during sepsis. Curr Infect Dis Rep 2005, 7: 349-354.PubMedCrossRef Albrecht EA, Ward PA: Complement-induced impairment of the innate immune system during sepsis. Curr Infect Dis Rep 2005, 7: 349-354.PubMedCrossRef
14.
go back to reference Monefeldt K, Helgeland K, Tollefsen T: In vitro activation of the classical pathway of complement by a streptococcal lipoteichoic acid. Oral Microbiol Immunol 1994, 9: 70-76.PubMedCrossRef Monefeldt K, Helgeland K, Tollefsen T: In vitro activation of the classical pathway of complement by a streptococcal lipoteichoic acid. Oral Microbiol Immunol 1994, 9: 70-76.PubMedCrossRef
15.
go back to reference Flierl MA, Rittirsch D, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ward PA: Functions of the complement components C3 and C5 during sepsis. FASEB J 2008, 22: 3483-3490.PubMedPubMedCentralCrossRef Flierl MA, Rittirsch D, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ward PA: Functions of the complement components C3 and C5 during sepsis. FASEB J 2008, 22: 3483-3490.PubMedPubMedCentralCrossRef
16.
go back to reference Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianfl one K, Köhl J, Gerard C, Sarma JV, Ward PA: Functional roles for C5a receptors in sepsis. Nat Med 2008, 14: 551-557.PubMedPubMedCentralCrossRef Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianfl one K, Köhl J, Gerard C, Sarma JV, Ward PA: Functional roles for C5a receptors in sepsis. Nat Med 2008, 14: 551-557.PubMedPubMedCentralCrossRef
17.
go back to reference Niederbichler AD, Hoesel LM, Westfall MV, Gao H, Ipaktchi KR, Sun L, Zetoune FS, Su GL, Arbabi S, Sarma JV, Wang SC, Hemmila MR, Ward PA: An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med 2006, 203: 53-61.PubMedPubMedCentralCrossRef Niederbichler AD, Hoesel LM, Westfall MV, Gao H, Ipaktchi KR, Sun L, Zetoune FS, Su GL, Arbabi S, Sarma JV, Wang SC, Hemmila MR, Ward PA: An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med 2006, 203: 53-61.PubMedPubMedCentralCrossRef
18.
go back to reference Croner RS, Lehmann TG, Fallsehr C, Herfarth C, Klar E, Kirschfink M: C1-inhibitor reduces hepatic leukocyte-endothelial interaction and the expression of VCAM-1 in LPS-induced sepsis in the rat. Microvasc Res 2004, 67: 182-191.PubMedCrossRef Croner RS, Lehmann TG, Fallsehr C, Herfarth C, Klar E, Kirschfink M: C1-inhibitor reduces hepatic leukocyte-endothelial interaction and the expression of VCAM-1 in LPS-induced sepsis in the rat. Microvasc Res 2004, 67: 182-191.PubMedCrossRef
19.
go back to reference Schmidt W, Stenzel K, Walther A, Gebhard MM, Martin E, Schmidt H: Influence of C1-esterase inhibitor on tissue oxygenation of jejunal mucosa during endotoxemia. Int J Surg Investig 1999, 1: 277-283.PubMed Schmidt W, Stenzel K, Walther A, Gebhard MM, Martin E, Schmidt H: Influence of C1-esterase inhibitor on tissue oxygenation of jejunal mucosa during endotoxemia. Int J Surg Investig 1999, 1: 277-283.PubMed
20.
go back to reference Lehmann C, Birnbaum J, Lührs C, Rückbeil O, Spies C, Ziemer S, Gründling M, Pavlovic D, Usichenko T, Wendt M, Kox WJ: Effects of C1 esterase inhibitor administration on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation during experimental endotoxemia. Intensive Care Med 2004, 30: 309-314.PubMedCrossRef Lehmann C, Birnbaum J, Lührs C, Rückbeil O, Spies C, Ziemer S, Gründling M, Pavlovic D, Usichenko T, Wendt M, Kox WJ: Effects of C1 esterase inhibitor administration on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation during experimental endotoxemia. Intensive Care Med 2004, 30: 309-314.PubMedCrossRef
21.
go back to reference Fischer MB, Prodeus AP, Nicholson-Weller A, Ma M, Murrow J, Reid RR, Warren HB, Lage AL, Moore FD Jr, Rosen FS, Carroll MC: Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement. J Immunol 1997, 159: 976-982.PubMed Fischer MB, Prodeus AP, Nicholson-Weller A, Ma M, Murrow J, Reid RR, Warren HB, Lage AL, Moore FD Jr, Rosen FS, Carroll MC: Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement. J Immunol 1997, 159: 976-982.PubMed
22.
go back to reference Giebler R, Schmidt U, Koch S, Peters J, Scherer R: Combined antithrombin III and C1-esterase inhibitor treatment decreases intravascular fibrin deposition and attenuates cardiorespiratory impairment in rabbits exposed to Escherichia coli endotoxin. Crit Care Med 1999, 27: 597-604.PubMedCrossRef Giebler R, Schmidt U, Koch S, Peters J, Scherer R: Combined antithrombin III and C1-esterase inhibitor treatment decreases intravascular fibrin deposition and attenuates cardiorespiratory impairment in rabbits exposed to Escherichia coli endotoxin. Crit Care Med 1999, 27: 597-604.PubMedCrossRef
23.
go back to reference Guerrero R, Velasco F, Rodriguez M, Lopez A, Rojas R, Alvarez MA, Villalba R, Rubio V, Torres A, del Castillo D: Endotoxin-induced pulmonary dysfunction is prevented by C1-esterase inhibitor. J Clin Invest 1993, 91: 2754-2760.PubMedPubMedCentralCrossRef Guerrero R, Velasco F, Rodriguez M, Lopez A, Rojas R, Alvarez MA, Villalba R, Rubio V, Torres A, del Castillo D: Endotoxin-induced pulmonary dysfunction is prevented by C1-esterase inhibitor. J Clin Invest 1993, 91: 2754-2760.PubMedPubMedCentralCrossRef
24.
go back to reference Jansen PM, Eisele B, de Jong IW, Chang A, Delvos U, Taylor FB Jr, Hack CE: Effect of C1 inhibitor on inflammatory and physiologic response patterns in primates suffering from lethal septic shock. J Immunol 1998, 160: 475-484.PubMed Jansen PM, Eisele B, de Jong IW, Chang A, Delvos U, Taylor FB Jr, Hack CE: Effect of C1 inhibitor on inflammatory and physiologic response patterns in primates suffering from lethal septic shock. J Immunol 1998, 160: 475-484.PubMed
25.
go back to reference Liu D, Cai S, Gu X, Scafidi J, Wu X, Davis AE: C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide. J Immunol 2003, 171: 2594-2601.PubMedCrossRef Liu D, Cai S, Gu X, Scafidi J, Wu X, Davis AE: C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide. J Immunol 2003, 171: 2594-2601.PubMedCrossRef
26.
go back to reference Liu D, Lu F, Qin G, Fernandes SM, Li J, Davis AE: C1 inhibitor-mediated protection from sepsis. J Immunol 2007, 179: 3966-3972.PubMedCrossRef Liu D, Lu F, Qin G, Fernandes SM, Li J, Davis AE: C1 inhibitor-mediated protection from sepsis. J Immunol 2007, 179: 3966-3972.PubMedCrossRef
27.
go back to reference Buerke M, Murohara T, Lefer AM: Cardioprotective effects of a C1 esterase inhibitor in myocardial ischemia and reperfusion. Circulation 1995, 91: 393-402.PubMedCrossRef Buerke M, Murohara T, Lefer AM: Cardioprotective effects of a C1 esterase inhibitor in myocardial ischemia and reperfusion. Circulation 1995, 91: 393-402.PubMedCrossRef
28.
go back to reference Buerke M, Prufer D, Dahm M, Oelert H, Meyer J, Darius H: Blocking of classical complement pathway inhibits endothelial adhesion molecule expression and preserves ischemic myocardium from reperfusion injury. J Pharmacol Exp Ther 1998, 286: 429-438.PubMed Buerke M, Prufer D, Dahm M, Oelert H, Meyer J, Darius H: Blocking of classical complement pathway inhibits endothelial adhesion molecule expression and preserves ischemic myocardium from reperfusion injury. J Pharmacol Exp Ther 1998, 286: 429-438.PubMed
29.
go back to reference Horstick G, Heimann A, Götze O, Hafner G, Berg O, Böhmer P, Becker P, Darius H, Rupprecht HJ, Loos M, Bhakdi S, Meyer J, Kempski O: Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion. Circulation 1997, 95: 701-708.PubMedCrossRef Horstick G, Heimann A, Götze O, Hafner G, Berg O, Böhmer P, Becker P, Darius H, Rupprecht HJ, Loos M, Bhakdi S, Meyer J, Kempski O: Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion. Circulation 1997, 95: 701-708.PubMedCrossRef
30.
go back to reference Horstick G, Berg O, Heimann A, Götze O, Loos M, Hafner G, Bierbach B, Petersen S, Bhakdi S, Darius H, Horstick M, Meyer J, Kempski O: Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: doserelated beneficial versus detrimental effects. Circulation 2001, 104: 3125-3131.PubMedCrossRef Horstick G, Berg O, Heimann A, Götze O, Loos M, Hafner G, Bierbach B, Petersen S, Bhakdi S, Darius H, Horstick M, Meyer J, Kempski O: Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: doserelated beneficial versus detrimental effects. Circulation 2001, 104: 3125-3131.PubMedCrossRef
31.
go back to reference Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, Liu D: Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun 2006, 349: 504-512.PubMedCrossRef Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, Liu D: Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun 2006, 349: 504-512.PubMedCrossRef
32.
go back to reference Fu J, Lin G, Zeng B, Wu Z, Wu Y, Chu H, Qin G, Liang G, Li J, Gan X, Yu X, Li C, Liu D: Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Biochem Biophys Res Commun 2006, 350: 162-168.PubMedCrossRef Fu J, Lin G, Zeng B, Wu Z, Wu Y, Chu H, Qin G, Liang G, Li J, Gan X, Yu X, Li C, Liu D: Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Biochem Biophys Res Commun 2006, 350: 162-168.PubMedCrossRef
33.
go back to reference Lu F, Chauhan AK, Fernandes SM, Walsh MT, Wagner DD, Davis AE: The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2008, 295: G1042-1049.PubMedCrossRef Lu F, Chauhan AK, Fernandes SM, Walsh MT, Wagner DD, Davis AE: The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2008, 295: G1042-1049.PubMedCrossRef
35.
go back to reference Niederau C, Brinsa R, Niederau M, Luthen R, Strohmeyer G, Ferrell LD: Effects of C1-esterase inhibitor in three models of acute pancreatitis. Int J Pancreatol 1995, 17: 189-196.PubMed Niederau C, Brinsa R, Niederau M, Luthen R, Strohmeyer G, Ferrell LD: Effects of C1-esterase inhibitor in three models of acute pancreatitis. Int J Pancreatol 1995, 17: 189-196.PubMed
36.
go back to reference Bhatia M, Saluja AK, Singh VP, Frossard JL, Lee HS, Bhagat L, Gerard C, Steer ML: Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 2001, 280: G974-978.PubMed Bhatia M, Saluja AK, Singh VP, Frossard JL, Lee HS, Bhagat L, Gerard C, Steer ML: Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 2001, 280: G974-978.PubMed
37.
go back to reference Tomasdottir H, Henriksson BA, Bengtson JP, Bengtsson A, Stenqvist O, Persson H: Complement activation during liver transplantation. Transplantation 1993, 55: 799-802.PubMedCrossRef Tomasdottir H, Henriksson BA, Bengtson JP, Bengtsson A, Stenqvist O, Persson H: Complement activation during liver transplantation. Transplantation 1993, 55: 799-802.PubMedCrossRef
38.
go back to reference Dalmasso AP, Platt JL: Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor. Transplantation 1993, 56: 1171-1176.PubMedCrossRef Dalmasso AP, Platt JL: Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor. Transplantation 1993, 56: 1171-1176.PubMedCrossRef
39.
go back to reference Fiane AE, Videm V, Johansen HT, Mellbye OJ, Nielsen EW, Mollnes TE: C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model. Immunopharmacology 1999, 42: 231-243.PubMedCrossRef Fiane AE, Videm V, Johansen HT, Mellbye OJ, Nielsen EW, Mollnes TE: C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model. Immunopharmacology 1999, 42: 231-243.PubMedCrossRef
40.
go back to reference Pöling J, Oezkur M, Kogge K, Mengel M, Niemann H, Winkler M, Haverich A, Wiebe K: Hyperacute rejection in ex vivo -perfused porcine lungs transgenic for human complement regulatory proteins. Transpl Int 2006, 19: 225-232.PubMedCrossRef Pöling J, Oezkur M, Kogge K, Mengel M, Niemann H, Winkler M, Haverich A, Wiebe K: Hyperacute rejection in ex vivo -perfused porcine lungs transgenic for human complement regulatory proteins. Transpl Int 2006, 19: 225-232.PubMedCrossRef
41.
go back to reference Schelzig H, Simon F, Krischer C, Vogel A, Abendroth D: Ex-vivo hemoperfusion (eHPS) of pig-lungs with whole human blood: effects of complement inhibition with a soluble C1-esterase-inhibitor. Ann Transplant 2001, 6: 34-39.PubMed Schelzig H, Simon F, Krischer C, Vogel A, Abendroth D: Ex-vivo hemoperfusion (eHPS) of pig-lungs with whole human blood: effects of complement inhibition with a soluble C1-esterase-inhibitor. Ann Transplant 2001, 6: 34-39.PubMed
42.
go back to reference Schröder C, Pfeiffer S, Wu G, Zorn GL, Ding L, Allen C, Harrison RA, White DJ, Azimzadeh AM, Pierson RN: Effect of complement fragment 1 esterase inhibition on survival of human decay-accelerating factor pig lungs perfused with human blood. J Heart Lung Transplant 2003, 22: 1365-1375.PubMedCrossRef Schröder C, Pfeiffer S, Wu G, Zorn GL, Ding L, Allen C, Harrison RA, White DJ, Azimzadeh AM, Pierson RN: Effect of complement fragment 1 esterase inhibition on survival of human decay-accelerating factor pig lungs perfused with human blood. J Heart Lung Transplant 2003, 22: 1365-1375.PubMedCrossRef
43.
go back to reference Hecker JM, Lorenz R, Appiah R, Vangerow B, Loss M, Kunz R, Schmidtko J, Mengel M, Klempnauer J, Piepenbrock S, Dickneite G, Neidhardt H, Rückoldt H, Winkler M: C1-inhibitor for prophylaxis of xenograft rejection after pig to cynomolgus monkey kidney transplantation. Transplantation 2002, 73: 688-694.PubMedCrossRef Hecker JM, Lorenz R, Appiah R, Vangerow B, Loss M, Kunz R, Schmidtko J, Mengel M, Klempnauer J, Piepenbrock S, Dickneite G, Neidhardt H, Rückoldt H, Winkler M: C1-inhibitor for prophylaxis of xenograft rejection after pig to cynomolgus monkey kidney transplantation. Transplantation 2002, 73: 688-694.PubMedCrossRef
44.
go back to reference Hecker JM, Loss M, Klempnauer J, Winkler M: C1-inhibitor for therapy and prophylaxis of acute vascular rejection of porcine kidneys in cynomolgus monkeys. Transplant Proc 2002, 34: 2382.PubMedCrossRef Hecker JM, Loss M, Klempnauer J, Winkler M: C1-inhibitor for therapy and prophylaxis of acute vascular rejection of porcine kidneys in cynomolgus monkeys. Transplant Proc 2002, 34: 2382.PubMedCrossRef
45.
go back to reference Radke A, Mottaghy K, Goldmann C, Khorram-Sefat R, Kovacs B, Janssen A, Klosterhalfen B, Hafemann B, Pallua N, Kirschfi nk M: C1 inhibitor prevents capillary leakage after thermal trauma. Crit Care Med 2000, 28: 3224-3232.PubMedCrossRef Radke A, Mottaghy K, Goldmann C, Khorram-Sefat R, Kovacs B, Janssen A, Klosterhalfen B, Hafemann B, Pallua N, Kirschfi nk M: C1 inhibitor prevents capillary leakage after thermal trauma. Crit Care Med 2000, 28: 3224-3232.PubMedCrossRef
46.
go back to reference Zwahlen A, Nydegger UE, Vaudaux P, Lambert PH, Waldvogel FA: Complement-mediated opsonic activity in normal and infected human cerebrospinal fluid: early response during bacterial meningitis. J Infect Dis 1982, 145: 635-646.PubMedCrossRef Zwahlen A, Nydegger UE, Vaudaux P, Lambert PH, Waldvogel FA: Complement-mediated opsonic activity in normal and infected human cerebrospinal fluid: early response during bacterial meningitis. J Infect Dis 1982, 145: 635-646.PubMedCrossRef
47.
go back to reference Zwijnenburg PJ, van der Poll T, Florquin S, Polfliet MM, van den Berg TK, Dijkstra CD, Roord JJ, Hack CE, van Furth AM: C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. J Infect Dis 2007, 196: 115-123.PubMedCrossRef Zwijnenburg PJ, van der Poll T, Florquin S, Polfliet MM, van den Berg TK, Dijkstra CD, Roord JJ, Hack CE, van Furth AM: C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. J Infect Dis 2007, 196: 115-123.PubMedCrossRef
48.
go back to reference Charneski L, Patel PN: Eculizumab in paroxysmal nocturnal haemoglobinuria. Drugs 2008, 68: 1341-1346.PubMedCrossRef Charneski L, Patel PN: Eculizumab in paroxysmal nocturnal haemoglobinuria. Drugs 2008, 68: 1341-1346.PubMedCrossRef
49.
go back to reference Hack CE, Voerman HJ, Eisele B, Keinecke HO, Nuijens JH, Eerenberg AJ, Ogilvie A, Strack van Schijndel RJ, Delvos U, Thijs LG: C1-esterase inhibitor substitution in sepsis. Lancet 1992, 339: 378.PubMedCrossRef Hack CE, Voerman HJ, Eisele B, Keinecke HO, Nuijens JH, Eerenberg AJ, Ogilvie A, Strack van Schijndel RJ, Delvos U, Thijs LG: C1-esterase inhibitor substitution in sepsis. Lancet 1992, 339: 378.PubMedCrossRef
50.
go back to reference Hack CE, Ogilvie AC, Eisele B, Jansen PM, Wagstaff J, Thijs LG: Initial studies on the administration of C1-esterase inhibitor to patients with septic shock or with a vascular leak syndrome induced by interleukin-2 therapy. Prog Clin Biol Res 1994, 388: 335-357.PubMed Hack CE, Ogilvie AC, Eisele B, Jansen PM, Wagstaff J, Thijs LG: Initial studies on the administration of C1-esterase inhibitor to patients with septic shock or with a vascular leak syndrome induced by interleukin-2 therapy. Prog Clin Biol Res 1994, 388: 335-357.PubMed
51.
go back to reference Caliezi C, Zeerleder S, Redondo M, Regli B, Rothen HU, Zürcher-Zenklusen R, Rieben R, Devay J, Hack CE, Lämmle B, Wuillemin WA: C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction. Crit Care Med 2002, 30: 1722-1728.PubMedCrossRef Caliezi C, Zeerleder S, Redondo M, Regli B, Rothen HU, Zürcher-Zenklusen R, Rieben R, Devay J, Hack CE, Lämmle B, Wuillemin WA: C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction. Crit Care Med 2002, 30: 1722-1728.PubMedCrossRef
52.
go back to reference Zeerleder S, Caliezi C, van Mierlo G, Eerenberg-Belmer A, Sulzer I, Hack CE, Wuillemin WA: Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis. Clin Diagn Lab Immunol 2003, 10: 529-535.PubMedPubMedCentral Zeerleder S, Caliezi C, van Mierlo G, Eerenberg-Belmer A, Sulzer I, Hack CE, Wuillemin WA: Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis. Clin Diagn Lab Immunol 2003, 10: 529-535.PubMedPubMedCentral
53.
go back to reference Lazareva NB, Igonin AA: [Safety and efficacy of purified human C1-esterase inhibitor in the treatment of patients with sepsis]. Antibiot Khimioter 2009, 54: 42-46.PubMed Lazareva NB, Igonin AA: [Safety and efficacy of purified human C1-esterase inhibitor in the treatment of patients with sepsis]. Antibiot Khimioter 2009, 54: 42-46.PubMed
54.
go back to reference Tapisiz A, Ergenekon E, Oktem M, Koc E, Okumus N, Zenciroğlu A, Atalay Y: C1 inhibitor level on neonatal sepsis and its relations with clinical findings. Paediatr Child Health 2010, 46: 121-124.CrossRef Tapisiz A, Ergenekon E, Oktem M, Koc E, Okumus N, Zenciroğlu A, Atalay Y: C1 inhibitor level on neonatal sepsis and its relations with clinical findings. Paediatr Child Health 2010, 46: 121-124.CrossRef
55.
go back to reference Bauernschmitt R, Bohrer H, Hagl S: Rescue therapy with C1-esterase inhibitor concentrate after emergency coronary surgery for failed PTCA. Intensive Care Med 1998, 24: 635-638.PubMedCrossRef Bauernschmitt R, Bohrer H, Hagl S: Rescue therapy with C1-esterase inhibitor concentrate after emergency coronary surgery for failed PTCA. Intensive Care Med 1998, 24: 635-638.PubMedCrossRef
56.
go back to reference de Zwaan C, Kleine AH, Diris JH, Glatz JF, Wellens HJ, Strengers PF, Tissing M, Hack CE, van Dieijen-Visser MP, Hermens WT: Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction. Eur Heart J 2002, 23: 1670-1677.PubMedCrossRef de Zwaan C, Kleine AH, Diris JH, Glatz JF, Wellens HJ, Strengers PF, Tissing M, Hack CE, van Dieijen-Visser MP, Hermens WT: Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction. Eur Heart J 2002, 23: 1670-1677.PubMedCrossRef
57.
go back to reference Thielmann M, Marggraf G, Neuhäuser M, Forkel J, Herold U, Kamler M, Massoudy P, Jakob H: Administration of C1-esterase inhibitor during emergency coronary artery bypass surgery in acute ST-elevation myocardial infarction. Eur J Cardiothorac Surg 2006, 30: 285-293.PubMedCrossRef Thielmann M, Marggraf G, Neuhäuser M, Forkel J, Herold U, Kamler M, Massoudy P, Jakob H: Administration of C1-esterase inhibitor during emergency coronary artery bypass surgery in acute ST-elevation myocardial infarction. Eur J Cardiothorac Surg 2006, 30: 285-293.PubMedCrossRef
58.
go back to reference Fattouch K, Bianco G, Speziale G, Sampognaro R, Lavalle C, Guccione F, Dioguardi P, Ruvolo G: Beneficial effects of C1 esterase inhibitor in ST-elevation myocardial infarction in patients who underwent surgical reperfusion: a randomised double-blind study. Eur J Cardiothorac Surg 2007, 32: 326-332.PubMedCrossRef Fattouch K, Bianco G, Speziale G, Sampognaro R, Lavalle C, Guccione F, Dioguardi P, Ruvolo G: Beneficial effects of C1 esterase inhibitor in ST-elevation myocardial infarction in patients who underwent surgical reperfusion: a randomised double-blind study. Eur J Cardiothorac Surg 2007, 32: 326-332.PubMedCrossRef
59.
go back to reference Nurnberger W, Heying R, Burdach S, Gobel U: C1 esterase inhibitor concentrate for capillary leakage syndrome following bone marrow transplantation. Ann Hematol 1997, 75: 95-101.PubMedCrossRef Nurnberger W, Heying R, Burdach S, Gobel U: C1 esterase inhibitor concentrate for capillary leakage syndrome following bone marrow transplantation. Ann Hematol 1997, 75: 95-101.PubMedCrossRef
60.
go back to reference Strüber M, Hagl C, Hirt SW, Cremer J, Harringer W, Haverich A: C1-esterase inhibitor in graft failure after lung transplantation. Intensive Care Med 1999, 25: 1315-1318.PubMedCrossRef Strüber M, Hagl C, Hirt SW, Cremer J, Harringer W, Haverich A: C1-esterase inhibitor in graft failure after lung transplantation. Intensive Care Med 1999, 25: 1315-1318.PubMedCrossRef
61.
go back to reference Kowal-Vern A, Walenga JM, Sharp-Pucci M, Hoppensteadt D, Gamelli RL: Postburn edema and related changes in interleukin-2, leukocytes, platelet activation, endothelin-1, and C1 esterase inhibitor. J Burn Care Rehabil 1997, 18: 99-103.PubMedCrossRef Kowal-Vern A, Walenga JM, Sharp-Pucci M, Hoppensteadt D, Gamelli RL: Postburn edema and related changes in interleukin-2, leukocytes, platelet activation, endothelin-1, and C1 esterase inhibitor. J Burn Care Rehabil 1997, 18: 99-103.PubMedCrossRef
63.
go back to reference Guo RF, Ward PA: C5a, a therapeutic target in sepsis. Recent Pat Antiinfect Drug Discov 2006, 1: 57-65.PubMedCrossRef Guo RF, Ward PA: C5a, a therapeutic target in sepsis. Recent Pat Antiinfect Drug Discov 2006, 1: 57-65.PubMedCrossRef
64.
go back to reference Drug Commission of the German Medical Profession: Serious Thrombogenesis Following Berinert HS Dtsch Arztebl 2000., 97: A-1016/B-864/C-812 Drug Commission of the German Medical Profession: Serious Thrombogenesis Following Berinert HS Dtsch Arztebl 2000., 97: A-1016/B-864/C-812
65.
66.
go back to reference Lou J, Lucas R, Grau GE: Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clin Microbiol Rev 2001, 14: 810-820.PubMedPubMedCentralCrossRef Lou J, Lucas R, Grau GE: Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clin Microbiol Rev 2001, 14: 810-820.PubMedPubMedCentralCrossRef
67.
go back to reference Levinson WE: Review of Medical Microbiology and Immunology. 9th edition. New York: McGraw-Hill Medical; 2006. Levinson WE: Review of Medical Microbiology and Immunology. 9th edition. New York: McGraw-Hill Medical; 2006.
Metadata
Title
Bench-to-bedside review: The role of C1-esterase inhibitor in sepsis and other critical illnesses
Authors
Mervyn Singer
Annie M Jones
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9304

Other articles of this Issue 1/2011

Critical Care 1/2011 Go to the issue