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Critical Care
Published in: Critical Care 5/2013

Open Access 01-10-2013 | Letter

Patient-centered outcomes and trials of hydroxyethyl starch

Authors: John Myburgh, Simon Finfer, Rinaldo Bellomo

Published in: Critical Care | Issue 5/2013

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Excerpt

Meybohm and colleagues [1] propose that hydroxyethyl starch (HES) may be used safely in hypovolemicpatients by applying a clinical algorithm and by restricting the doseadministered. …
Literature
1.
Meybohm P, Van Aken H, De Gasperi A, De Hert S, Della Rocca G, Girbes AR, Gombotz H, Guidet B, Hasibeder W, Hollmann MW, Ince C, Jacob M, Kranke P, Kozek-Langenecker S, Loer SA, Martin CD, Siegemund M, Wunder C, Zacharowski K: Re-evaluating currently available data and suggestions for planningrandomised controlled studies regarding the use of hydroxyethyl-starch incritically ill patients - a multidisciplinary statement. Crit Care 2013, 17: R166. 10.1186/cc12845PubMedCentralCrossRefPubMed
2.
Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McgGuinness S, Rajbhandari D, Taylor CB, Webb SAR, the CHEST Investigators and the Australian and New Zealand IntensiveCare Society Clinical Trials Group: Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 2012, 367: 1901-1911. 10.1056/NEJMoa1209759CrossRefPubMed
3.
Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, Madsen KR, Møller MH, Elkjær JM, Poulson LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quiset L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjældgaard A-L, Fabritius ML, Mondrup F, Pott FC, et al.: Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severesepsis. N Engl J Med 2012, 367: 124-134. 10.1056/NEJMoa1204242CrossRefPubMed
4.
Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K, German Competence Network Sepsis (SepNet): Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008, 358: 125-139. 10.1056/NEJMoa070716CrossRefPubMed
5.
Bellmann R, Feistritzer C, Wiedermann CJ: Effect of molecular weight and substitution on tissue uptake of hydroxyethylstarch: a meta-analysis of clinical studies. Clin Pharmacokinet 2012, 51: 225-236. 10.2165/11594700-000000000-00000CrossRefPubMed
6.
Mutter TC, Ruth CA, Dart AB: Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidneyfunction. Cochrane Database Syst Rev 2013, 7:-CD007594.
Metadata
Title
Patient-centered outcomes and trials of hydroxyethyl starch
Authors
John Myburgh
Simon Finfer
Rinaldo Bellomo
Publication date
01-10-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13023

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